Navigation Links
What are protective effects of anti-ricin A-chain aptamer?
Date:12/29/2008

Ricin, a lectin from the castor bean plant Ricinus communis is considered one of the most potent plant toxins. Ricin poisoning can cause severe tissue damage and inflammation and can result in death. Most accidental exposures occur by ingestion of the seeds of castor beans whereby the toxin is released after the seed coat is damaged. The ingested toxin causes severe gastrointestinal damage with symptoms and death due to multiorgan failure or cardiovascular collapse.

A research article to be published on November 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team was led by Dr. Kam-Meng Tchou-Wong from New York University School of Medicine in United States.

Authors investigated the therapeutic potential of an RNA ligand (aptamer) specific for the catalytic ricin A-chain (RTA), the protective effects of a 31-nucleotide RNA aptamer (31RA), which formed a high affinity complex with RTA, against ricin-induced toxicity in cell-based luciferase translation and cell cytotoxicity assays were evaluated.

They have shown that 31RA RNA aptamer can protect against ricin ribotoxicity in cell-based luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication.

In this report, authors utilized a stable cell-based luciferase assay and showed that 31RA aptamer also neutralized the inhibitory effects of ricin on translation inhibition in cell-free and cell-based luciferase assays and ricin-induced cytotoxicity assay. The use of a stably transfected cell-based luciferase assay will facilitate the development of high throughput screening for inhibitors of ricin as potential antidotes for the treatment of ricin intoxication.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Simon Property Group Selects New York Merchants Protective Co., Inc. for Fire-alarm Services
2. No protective effect on cancer from long-term vitamin E or vitamin C supplementation
3. Study Finds Folic Acid Not Cardioprotective, Though Safe
4. Studies examine treatment for gout and the conditions protective effects
5. New Journal to Explore Neurodegenerative, Neuroprotective and Euroregenerative Therapies!
6. Breast-Feeding More Protective for Girls Than Boys
7. Protective Eyewear Key to Sports Safety
8. Double duty: Loss of protective heart failure protein causes high blood pressure
9. New research shows neuroprotective effect of lovastatin
10. Researchers Create Protective Sac for Growing Stem Cells
11. Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2020)... ... 28, 2020 , ... iPatientCare, a pioneer in cloud-based ... solutions has expanded the availability of telehealth services and other initiatives to help ... has a big role in fighting coronavirus . Increasing the telehealth services across ...
(Date:3/27/2020)... SCOTCH PLAINS, N.J. (PRWEB) , ... March 27, ... ... Associates has been reviewed and approved by NJ Top Docs. Dr. Kubeck has ... the American Board of Orthopaedic Surgery and specializes in Spinal Surgery. , ...
(Date:3/27/2020)... PLEASANTON, Calif. (PRWEB) , ... March 27, 2020 ... ... (NYSE:TFX) focused on addressing unmet needs in the field of urology, today announced ... designated as a UroLift® Center of Excellence. The designation recognizes that Dr. Wadhwa ...
(Date:3/22/2020)... ... March 21, 2020 , ... ... and the Modular Home Builders Association (MHBA), have been working with state and ... MHBA has been advocating for greater use of modular construction to address the ...
(Date:3/22/2020)... ... March 21, 2020 , ... TriageLogic, a leader in ... organizations, and health centers can use for patient care during the COVID-19 crisis. ... professionals are working around the clock to implement emergency support solutions for patients ...
Breaking Medicine News(10 mins):
(Date:3/28/2020)... MARIN, Calif. (PRWEB) , ... March 27, 2020 , ... ... Skincare line, Wendy May Real has launched a new hand sanitizer in response to ... the niche hand sanitizer market will continue to expand during the next several months ...
(Date:3/28/2020)... ... March 28, 2020 , ... TriageLogic, a leader in remote ... telehealth system with a virtual call center that hospitals, medical organizations, and health centers ... to the coronavirus pandemic, they are looking for a system that can be quickly ...
(Date:3/27/2020)... ISLAND, N.Y. (PRWEB) , ... March 27, 2020 , ... ... Pismichenko wanted to use the podcast format was because she’d be able to explain ... people out there who are curious, and want to learn more about the process ...
Breaking Medicine Technology: