Navigation Links
What Causes Mystery Heart Condition?
Date:3/26/2009

Stress cardiomyopathy linked to common drugs, study finds

THURSDAY, March 26 (HealthDay News) -- The unusual heart syndrome called stress cardiomyopathy can be triggered by some commonly used heart medications, Johns Hopkins University researchers report.

Nine cases of the condition followed injections of adrenaline or dobutamine, according to a report in the March 25 online issue of the Journal of the American College of Cardiology.

Both dobutamine and adrenaline (which physicians prefer to call epinephrine) are used to increase the heart's ability to pump blood. The report that they can cause stress cardiomyopathy might provide at least a partial solution to the riddle presented by the condition, said study senior author Dr. Ilan S. Wittstein, an assistant professor of medicine at Hopkins.

Stress cardiomyopathy was first described in Japan in the early 1990s, and has been called Takotsubo cardiomyopathy. It is sometimes called "broken heart syndrome," since it can be precipitated by an intense physical or emotional event.

Its symptoms resemble those of a heart attack, including intense chest pain and shortness of breath, but the underlying physical cause is different -- not the death of heart muscle seen in a heart attack, but instead a temporary weakening of the heart. It generally is not fatal, but aggressive management usually is needed to get patients through a critical early period.

"On an echocardiogram, you can actually see the walls of the heart not squeezing, a ballooning pattern of the heart muscle," Wittstein said.

While epinephrine and dobutamine affect the heart, they can be used to treat non-cardiac conditions. One woman described in the report was given epinephrine for nausea while she underwent liposuction. Another patient was given a too-high dose of epinephrine intended to stop bleeding during a colonoscopy.

"There have been previous reports of stress cardiomyopathy after dobutamine and a few case reports of heart muscle dysfunction after epinephrine," Wittstein sad. "We are the first to report a series of such cases."

While an overdose can trigger the condition, "some of the patients received the right dose of the medicine and developed it anyway, so there may be susceptibility in some people," he said. "The issue is why some people get it and some don't."

There are several messages to physicians in the report, Wittstein said. "One is that this is happening after routine procedures, so it is probably happening more than people are picking up now," he said. "So we need to recognize the clinical features of the syndrome, because it is likely more common than people know.

"Another message is that we need to be careful about the dosage of these medications."

Yet stress cardiomyopathy was seen in some people who got normal doses of the drugs, Wittstein said. "It may even be genetic," he said. "There are people who are vulnerable, and we don't know who they are. It is important to figure out who those people are."

More light is shed by a report in the March 26 issue of the American Journal of Cardiology by physicians at The Miriam Hospital, which is associated with the Warren Alpert Medical School of Brown University in Providence, R.I.

A group led by Dr. Richard Regnante, an interventional cardiology fellow, has created a registry of 70 cases of stress cardiomyopathy, the largest to date. Two-thirds of them had experienced a physical or psychological stressful event, such as an auto accident or bad news about a family member. All eventually recovered, although two had a recurrence of the condition.

"This data will help us better understand the disease process and could play a major role in developing and tailoring more effective short- and long-term treatment strategies," Regnante said in a statement.

More information

Questions about stress cardiomyopathy are answered by Johns Hopkins University.



SOURCES: Ilan S. Wittstein, M.D., assistant professor, medicine, Johns Hopkins University, Baltimore; March 25, 2009, Journal of the American College of Cardiology, online; March 26, 2009, American Journal of Cardiology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Acetaldehyde in alcohol -- no longer just the chemical that causes a hangover
2. Study finds injectable birth control causes significant weight gain and changes in body mass
3. Experts examine causes, treatment and prevention of glaucoma
4. Varicella zoster infection causes severe autoimmune hepatitis
5. Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
6. Sleep disordered breathing and obesity: Independent effects, causes
7. Nanotechnology Causes Disruption - Cross Industry
8. UBC researchers discover gene mutation that causes eye cancer
9. Study sheds light on causes of HIV dementia
10. Study identifies causes of bone loss in breast cancer survivors
11. APIC Covers Up Extent and Causes of Deadly C. diff
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What Causes Mystery Heart Condition?
(Date:6/28/2017)... ... June 28, 2017 , ... Guide to FDA and EU Medical Device Regulations: ... which side of the Atlantic devicemakers do business, this fully updated and expanded guide ... In addition to the full text of the FDA’s regulations in 21 CFR Parts ...
(Date:6/28/2017)... ... ... remote control has seen the never-ending twists on the house flipping show genre. The shows ... time. But what about the buyers of the flipper's flip. , Here is ... An email recently sent to Gary Case said, “Just closed on a home on ...
(Date:6/28/2017)... , ... June 28, 2017 , ... David B. Sosin, a founding partner ... took over the post of 2nd Vice President for the Illinois State Bar Association ... as the ISBA’s 3rd Vice President in 2016 following a state-wide election and served in ...
(Date:6/28/2017)... FL (PRWEB) , ... June 28, 2017 , ... American ... an upcoming episode of the award winning television series, scheduled to broadcast fourth quarter ... Line Seeds originated as a regional supplier of garden pea seed. As demand grew, ...
(Date:6/28/2017)... ... 28, 2017 , ... Canadian Zeolite Corp. (the “Company”) (TSX.V: ... study conducted by the University of Saskatchewan in partnership with PotashCorp, Agrium and ... groundwater. As a part of the study, batch adsorption experiments were conducted with ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 AirXpanders, Inc. (ASX: ... on the design, manufacture, sale and distribution of the ... the progress of its commercial roll-out in ... in more than one hundred (100) medical institutions and ... AeroForm offers a needle-free alternative for women who choose ...
(Date:6/8/2017)... 2017  StatLab Medical Products ("StatLab" or ... of diagnostic supplies for the anatomic pathology ... Company LP ("Cressey & Company"), a healthcare-focused ... investment in the Company. Cressey & Company ... selling shareholder, Prairie Capital, L.P., with certain ...
(Date:6/5/2017)... CINCINNATI , June 5, 2017 The ... a brand of Diplomat Pharmacy, Inc. (NYSE: DPLO), has been ... Cincinnati Enquirer . Results are based on ... specializing in organizational health and workplace improvement. The survey measures ... ...
Breaking Medicine Technology: