Navigation Links
What Causes Mystery Heart Condition?
Date:3/26/2009

Stress cardiomyopathy linked to common drugs, study finds

THURSDAY, March 26 (HealthDay News) -- The unusual heart syndrome called stress cardiomyopathy can be triggered by some commonly used heart medications, Johns Hopkins University researchers report.

Nine cases of the condition followed injections of adrenaline or dobutamine, according to a report in the March 25 online issue of the Journal of the American College of Cardiology.

Both dobutamine and adrenaline (which physicians prefer to call epinephrine) are used to increase the heart's ability to pump blood. The report that they can cause stress cardiomyopathy might provide at least a partial solution to the riddle presented by the condition, said study senior author Dr. Ilan S. Wittstein, an assistant professor of medicine at Hopkins.

Stress cardiomyopathy was first described in Japan in the early 1990s, and has been called Takotsubo cardiomyopathy. It is sometimes called "broken heart syndrome," since it can be precipitated by an intense physical or emotional event.

Its symptoms resemble those of a heart attack, including intense chest pain and shortness of breath, but the underlying physical cause is different -- not the death of heart muscle seen in a heart attack, but instead a temporary weakening of the heart. It generally is not fatal, but aggressive management usually is needed to get patients through a critical early period.

"On an echocardiogram, you can actually see the walls of the heart not squeezing, a ballooning pattern of the heart muscle," Wittstein said.

While epinephrine and dobutamine affect the heart, they can be used to treat non-cardiac conditions. One woman described in the report was given epinephrine for nausea while she underwent liposuction. Another patient was given a too-high dose of epinephrine intended to stop bleeding during a colonoscopy.

"There have been previous reports of stress cardiomyopathy after dobutamine and a few case reports of heart muscle dysfunction after epinephrine," Wittstein sad. "We are the first to report a series of such cases."

While an overdose can trigger the condition, "some of the patients received the right dose of the medicine and developed it anyway, so there may be susceptibility in some people," he said. "The issue is why some people get it and some don't."

There are several messages to physicians in the report, Wittstein said. "One is that this is happening after routine procedures, so it is probably happening more than people are picking up now," he said. "So we need to recognize the clinical features of the syndrome, because it is likely more common than people know.

"Another message is that we need to be careful about the dosage of these medications."

Yet stress cardiomyopathy was seen in some people who got normal doses of the drugs, Wittstein said. "It may even be genetic," he said. "There are people who are vulnerable, and we don't know who they are. It is important to figure out who those people are."

More light is shed by a report in the March 26 issue of the American Journal of Cardiology by physicians at The Miriam Hospital, which is associated with the Warren Alpert Medical School of Brown University in Providence, R.I.

A group led by Dr. Richard Regnante, an interventional cardiology fellow, has created a registry of 70 cases of stress cardiomyopathy, the largest to date. Two-thirds of them had experienced a physical or psychological stressful event, such as an auto accident or bad news about a family member. All eventually recovered, although two had a recurrence of the condition.

"This data will help us better understand the disease process and could play a major role in developing and tailoring more effective short- and long-term treatment strategies," Regnante said in a statement.

More information

Questions about stress cardiomyopathy are answered by Johns Hopkins University.



SOURCES: Ilan S. Wittstein, M.D., assistant professor, medicine, Johns Hopkins University, Baltimore; March 25, 2009, Journal of the American College of Cardiology, online; March 26, 2009, American Journal of Cardiology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Acetaldehyde in alcohol -- no longer just the chemical that causes a hangover
2. Study finds injectable birth control causes significant weight gain and changes in body mass
3. Experts examine causes, treatment and prevention of glaucoma
4. Varicella zoster infection causes severe autoimmune hepatitis
5. Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
6. Sleep disordered breathing and obesity: Independent effects, causes
7. Nanotechnology Causes Disruption - Cross Industry
8. UBC researchers discover gene mutation that causes eye cancer
9. Study sheds light on causes of HIV dementia
10. Study identifies causes of bone loss in breast cancer survivors
11. APIC Covers Up Extent and Causes of Deadly C. diff
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
What Causes Mystery Heart Condition?
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
(Date:9/12/2017)... FRANCISCO , Sept. 12, 2017  ValGenesis ... Management Solutions (VLMS), is pleased to announce the ... a member of its Board of Directors and ... ValGenesis VLMS enables life science companies to manage ... the use of paper in this process. Furthermore, ...
Breaking Medicine Technology: