Navigation Links
Western diets turn on fat genes
Date:11/30/2009

Those extra helpings of gravy and dessert at the holiday table are even less of a help to your waistline than previously thought. According to a new research report recently appearing online in The FASEB Journal (http://www.fasebj.org), a diet that is high in fat and in sugar actually switches on genes that ultimately cause our bodies to store too much fat. This means these foods hit you with a double-whammy as the already difficult task of converting high-fat and high-sugar foods to energy is made even harder because these foods also turn our bodies into "supersized fat-storing" machines.

In the research report, scientists show that foods high in fat and sugar stimulate a known opioid receptor, called the kappa opioid receptor, which plays a role in fat metabolism. When this receptor is stimulated, it causes our bodies to hold on to far more fat than our bodies would do otherwise.

According to Traci Ann Czyzyk-Morgan, one of the researchers involved in the work, "the data presented here support the hypothesis that overactivation of kappa opioid receptors contribute to the development of obesity specifically during prolonged consumption of high-fat, calorically dense diets."

To make this discovery, Czyzyk-Morgan and her colleagues conducted tests in two groups of mice. One group had the kappa opioid receptor genetically deactivated ("knocked out") and the other group was normal. Both groups were given a high fat, high sucrose, energy dense diet for 16 weeks. While the control group of mice gained significant weight and fat mass on this diet, the mice with the deactivated receptor remained lean. In addition to having reduced fat stores, the mice with the deactivated receptor also showed a reduced ability to store incoming nutrients.

Although more work is necessary to examine what the exact effects would be in humans, this research may help address the growing obesity problem worldwide in both the short-term and long-term. Most immediately, this research provides more proof that high-fat and high-sugar diets should be avoided. In the long-term, however, this research is even more significant, as it provides a new drug target for developing therapies for preventing obesity and helping obese people slim down.

"In times when food was scarce and starvation an ever-present threat, an adaptation that allows our bodies to store as much energy as possible during plentiful times was probably a lifesaver," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "By taking that opioid receptor off the table, researchers may have found a way to keep us from eating ourselves to death."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Parent mentors can improve the asthmatic care of minority children, UT Southwestern researchers find
2. Holistic and Western Medicine Combined Can Fight Cancer
3. UT Southwestern receives continued NIH funding for Inner City Asthma Consortium
4. Case Western School of Medicine receives RWJF grant to establish a public health research network
5. Finding Ways for Disabled People to Participate in Research is Goal of Case Western Reserve University Nursing School Study
6. Mastery of Myeloma Continuing Education Training Program for the Multidisciplinary Care Team Set for Western Region
7. Case Western Reserve University receives $20.5 million
8. Partnership for Prescription Assistance Prepared to Help Midwestern Workers Hurt by Recession
9. Case Western Reserve awarded $1.57M for corneal infection research
10. Director of UT Southwestern center honored with first international neurology medal
11. Dynatronics to Supply Western Rehabilitation Health Networks 114 Clinics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... The Gallery ... Kevin Sadati, is pleased to announce a new treatment option called Vivace Microneedling. ... their face, neck, and body through a virtually pain-free, non-surgical treatment. Vivace Microneedling ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients from Charleston, SC, are ... dentist practicing in Mt. Pleasant, SC, with or without a referral. A full mouth ... with missing teeth in Charleston, SC. Those who suffer from gum disease, ...
(Date:5/23/2017)... WI (PRWEB) , ... May 23, 2017 , ... Patients ... to call Dr. Angela Cotey’s practice to schedule an appointment, with or without a ... and frequently offers pulpotomy treatments to pediatric patients as a healthy alternative to a ...
(Date:5/22/2017)... PA (PRWEB) , ... May 22, 2017 , ... An ... to write with a pen. "My wife’s hand was damaged in a firework accident, ... something that helps people with manual problems." , He then designed and created a ...
(Date:5/22/2017)... ... May 22, 2017 , ... ... larger group investing in InsightRX, an early stage company in San Francisco that ... pharmacological characteristics. Greatpoint Ventures Innovation Fund acted as the lead investor ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
(Date:5/15/2017)... Inc., a privately-held CNS pharmaceutical company based in ... disease (PD), has enrolled the first patient in the RASMET ... study involving patients with PD and taking place at 12 ... period. The first stage is open label and involves single ... Denver , Boca Raton ...
(Date:5/10/2017)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... quarter ended April 1, 2017 .   GAAP diluted ... to the prior year period as the sale of ... while non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue ... currency terms.  Excluding the effects of blood screening and ...
Breaking Medicine Technology: