Navigation Links
West Nile virus infection may persist in kidneys years after initial infection
Date:12/7/2009

A new study shows that people who have been infected with West Nile virus may have persistent virus in their kidneys for years after initial infection, potentially leading to kidney problems. The research, which appears in the January 1 issue of The Journal of Infectious Diseases, is now available online (http://www.journals.uchicago.edu/doi/abs/10.1086/648731).

Spread by infected mosquitoes, West Nile virus was first detected in the United States in 1999. Since then, approximately 25,000 human cases have been reported, causing more than 1,000 deaths. Many more have become infected without showing symptoms. Previous animal studies raised the possibility that patients may still be infected with the virus several years after recovering from their initial illness. Prior to this latest research, however, humans were thought to remain infected with West Nile virus only for the first few days of illness. The study, led by Kristy Murray, DVM, PhD at the University of Texas School of Public Health in Houston, demonstrates that not all individuals clear the virus from their system within the first few daysand that it can remain in the kidneys for years, potentially leading to kidney failure.

Dr. Murray and her colleagues followed more than 100 patients in Houston with severe initial West Nile virus infections for seven years. Individuals were evaluated and blood samples collected every six months. More than half continued to have infection-related symptoms years after their initial illness, although symptoms began to plateau around two years after infection. The deaths of five participants due to kidney failure led researchers to consider whether the kidney could be a preferred replication site for the virus.

To test this hypothesis, Dr. Murray and her team collected urine samples from 25 patients from their original cohort and tested them for presence of West Nile virus. In this group, five patients (20 percent) tested positive for the virus. Viral RNA could be detected in the urine for at least six years following infection. Four of the five patients who tested positive for virus also experienced chronic symptoms. Of these five, one patient developed kidney failure. These results show that West Nile virus is capable of long term persistence in patients, particularly when chronic symptoms are present.

In an accompanying editorial, Ernest Gould, PhD, of the Centre for Ecology and Hydrology in Oxford, England, points out that this study raises the additional concern that West Nile virus and other flaviviruses may be transmitted to mosquitoes by apparently healthy humans or animals. This possibility has the potential to start epidemics in new regions of the world.

According to Dr. Murray, patients who have been infected with West Nile virus should "have their kidneys monitored by their physician for any evidence of disease and be aware that persistent infection of the kidneys can happen." Dr. Murray also reminds the public to take proper precautions to protect themselves from mosquito bites during transmission seasons, typically the summer and fall, to avoid infection.

More research is needed to "understand the underlying mechanisms related to the shedding of virus particles in urine, whether shedding of the virus is constant or intermittent, and whether or not this represents true infection resulting in kidney disease," the investigators say. They continue to evaluate all study participants, particularly in regard to kidney function. In addition, they are focusing on developing treatment options for those who remain infected with the virus.

Fast Facts

  • Individuals who have had severe infections with West Nile virus may harbor the virus in their kidneys for many years.
  • This study suggests that individuals infected with West Nile virus should have their kidneys monitored for disease and be aware that disease persistence can occur.


'/>"/>

Contact: John Heys
jheys@idsociety.org
703-299-0412
Infectious Diseases Society of America
Source:Eurekalert

Related medicine news :

1. FDA, CDC, and States Investigating Norovirus Illnesses Linked to Oysters
2. Tips on Decreasing Susceptibility to the H1N1 Virus - Optimum Oral Hygiene Can Prevent Flu
3. Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased
4. H1N1 News Today Examines the Swine Flu Virus From a Global Perspective; Read the Latest H1N1 Virus Vaccine & Prevention News From EIN News
5. FreedomVOICE Proposes Telecommuting to Tackle the H1N1 Virus
6. Swine Flu Virus Dominant Strain Worldwide: WHO
7. Coway Announces New Anti-Flu Air Filter Can Inactivate 2009 Seasonal Flu Virus
8. Rotavirus Vaccine Cutting Infection Rates Among Kids
9. CT scans better than X-rays when detecting abnormalities in patients with H1N1 virus
10. Reeves College Prepares Campuses for H1N1 Virus
11. Government of Canada supports scientific research to deepen knowledge of H1N1 flu virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... D.C., for the 49th Congress of the International Society of Paediatric Oncology ... the Center for Cancer and Blood Disorders at Children’s National, and Stephen ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/18/2017)... 2017 EpiVax, Inc. ("EpiVax") a ... immune engineering, today announced a new NIH-funded ... ... and presents a challenge for traditional flu ... be effective. Using state-of-the-art bioinformatics and molecular modeling methods, ...
Breaking Medicine Technology: