Navigation Links
Welsh scientists 'clone' human virus

A team of Welsh scientists have successfully cloned a human virus offering new hope for the treatment of potentially life-threatening diseases.

Human cytomegalovirus (HCMV) is a major infectious cause of congenital malformations worldwide. The virus is also known to cause life-threatening disease in transplant patients and people with HIV/AIDS.

The development of new treatments has been hampered as scientists have been unable to stably replicate HCMV outside the human body.

Dr Richard Stanton from Cardiff University's School of Medicine who led the joint research, said: "HCMV has by far the largest genome of all viruses affecting humans - consequently it was technically difficult to clone in an intact form in the laboratory.

"Cloning a copy of the virus from a strain isolated by Cardiff Public Health Laboratories has enabled us to identify the genes causing the instability of the virus outside the body.

"Following the identification of these genes, we have successfully developed cells in which we can grow virus that corresponds to that which exists in the human body."

Cloning the virus for the first time will help virologists develop antivirals and vaccines against the virus that causes clinical disease.

Following the study, the clone has already been distributed to research laboratories worldwide, and is being tested by the World Health Organisation (WHO) as part of a study to develop an international diagnostic standard with which to compare clinical isolates.

The genome sequence of the Cardiff virus has also been designated the international reference for HCMV in the National Centre for Biotechnology Information (NCBI) - an international database that provides reference standards for biomedical and genomic information.

Dr Stanton added: "HCMV has been designated as a highest priority vaccine target by the US Institute of Medicine. When developing vaccines, anti-viral agents and improving understanding of disease, it is crucial to work with a virus that accurately represents the virus present in patients.

"For the first time our work has enabled us to create an exact copy of the virus outside of the body offering a vital step forward in the development of new treatments."

The study, published in the The Journal of Clinical Investigationand funded by the Wellcome Trust and the Medical Research Council, was a joint collaboration between Cardiff University's Infection, Immunity and Inflammation Interdisciplinary Research Group and Drs Davison and Dargan at the Centre for Virus Research at the University of Glasgow.

The virus, named Merlin, was isolated from a clinical sample identified by the Diagnostic Unit, Public Health Wales.


Contact: Dr. Rich Stanton
Cardiff University

Related medicine news :

1. Welsh shingles drug set for final hurdle
2. Welsh Tree LLC Proudly Presents the Release of the Celtic Pathways CD by Jason Evans, in Time for Saint Patrick's Day
3. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
4. Scientists identify molecular gatekeeper of arthritis
5. Scientists make leap forward in early detection for Alzheimers and cancer
6. Scientists discover the mechanisms and function of a type of mysterious immune cell
7. Scientists unwrap DNA packaging to gain insight into cells
8. Scientists discover key to Christmas Islands red crab migration
9. Scientists find link in humans between nerve cell production, memory
10. Scientists Dismayed by Stem Cell Research Ruling
11. Scientists closer to finding what causes the birth of a fat cell
Post Your Comments:
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... Amanda Beard and Brooke Bennett are collaborating with brands across various categories through ... four influential figures make up an elite group of Gold Medal Moms who ...
(Date:11/30/2015)... Turks & Caicos Islands, BWI (PRWEB) , ... December 01, 2015 ... ... in 2015. Recently Caribbean Journal, one of the leading digital news sites highlighting ... The top reason? The weather. While much of North America shivers under chilly ...
(Date:11/30/2015)... Garden City, NY (PRWEB) , ... December 01, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. She ... is the nation’s leading networking organization exclusively for professional women, boasting more than 850,000 ...
(Date:11/30/2015)... ... 30, 2015 , ... 1Heart Caregiver Services’ Executive Team actively ... Philippine American Chambers of Commerce held from November 6-8, 2015 at the Monte ... as an active delegate from the Philippine American Chamber of Commerce of Greater ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... also extremely stressful. At the VA Maryland Health Care System, the Caregiver ... veterans patients. “Caregivers have a difficult job. Seventy-four percent report that their ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 01, 2015 ... announced the addition of the ... Campylobacter, Cryptosporidium, E. Coli, Enterovirus, Rhinovirus, ... report to their offering. --> ... addition of the "2016 Europe ...
(Date:12/1/2015)... December 1, 2015 ... Topical Contraceptives, Male Condoms, Female Condoms, Intrauterine ... Contraceptive Diaphragms, Contraceptive Sponges, Non-Surgical Permanent Contraception ... Growth, Trends and Forecast 2014 - 2020 ... Research (TMR).The report states that the global ...
(Date:12/1/2015)... Pa. , Dec. 1, 2015  Today, ... announced the launch of CareFront, a first-of-its-kind population ... patients diagnosed with cancer. Designed to be built ... diagnosed cancer patients with resources for their care ... The program also offers tools to help patients ...
Breaking Medicine Technology: