Navigation Links
Well-known protein reveals new tricks
Date:9/6/2012

A protein called "clathrin," which is found in every human cell and plays a critical role in transporting materials within them, also plays a key role in cell division, according to new research at the University of California, San Francisco.

The discovery, featured on the cover of the Journal of Cell Biology in August, sheds light on the process of cell division and provides a new angle for understanding cancer. Without clathrin, cells divide erratically and unevenlya phenomenon that is one of the hallmarks of the disease.

"Clathrin is doing more than we thought it was doing," said Frances Brodsky, DPhil, who led the research. Brodsky is a professor in the UCSF Department of Bioengineering and Therapeutic Sciences, a joint department of the Schools of Pharmacy and Medicine, and she holds joint appointments in Microbiology and Immunology, as well as Pharmaceutical Chemistry.

A Protein Essential for Transportation in More Than One Route

Akin to a three-pronged building block in a child's construction set, clathrin can provide links to create larger complexes. When lots of these proteins are assembled together, they can form tough little cages into which cells packs many of their essential biological moleculeshormones, neurotransmitters, membrane proteins and other payloads that need to be transported throughout the cell.

Once thought to be solely involved in transport inside cells, scientists have uncovered more and more of the protein's hidden functions in the last half-dozen years, including some roles it plays in cell division.

For instance, they learned several years ago about its role in the function of "spindles." Normally when a cell divides, it forms a spindle by laying down tracks of structural proteins, and uses them as scaffolding to separate the cell's DNA (in the form of chromosomes) into two equal collectionsone identical set of DNA for each of the new daughter cells. Scientists found that clathrin is involved in stabilizing these spindles.

Now, however, Brodsky and her colleagues have shown that clathrin does even more. They deleted clathrin from cells using a technique called RNA interference, which involves infusing in small genetic fragments that block the cell from making the clathrin. Doing so, Brodsky and her colleagues showed that clathrin stabilizes the structures in dividing cells known as centrosomes.

Tagged with fluorescent chemicals and viewed under a microscope, the centrosomes within a cell that is about to divide look like two glowing eyes peering through the dark. But without clathrin, the team determined, the eyes increase in number.

Brodsky and her colleagues traced this effect to a protein complex formed by one particular component of clathrin called CHC17, which directly stabilizes the centrosome and helps it mature. Deleting CHC17 or chemically inactivating it, led to cells with a strange appearance. These cells contained multiple, fragmented centrosomes instead of the normal two and built abnormal spindles.

This discovery may reveal pathways towards abnormalities of chromosome segregation associated with cancer, said Brodsky.


'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Related medicine news :

1. Well-known author and historian reports on progress in Huntingtons therapies
2. Warwick scientists uncover how checkpoint proteins bind chromosomes
3. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
4. Unusual protein helps regulate key cell communication pathway
5. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
6. RANK protein promotes the initiation, progression and metastasis of human breast cancer
7. Protein may represent a switch to turn off B cell lymphoma
8. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
9. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
10. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
11. New molecular structure offers first picture of a protein family vital to human health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Well-known protein reveals new tricks
(Date:2/18/2017)... Aliso Viejo, CA (PRWEB) , ... February 18, ... ... styled animating paragraph presets. Use Pixel Film Studios ’ ProParagraph Fashion ... listings, descriptions, and so many other applications. Users can pick and choose ...
(Date:2/17/2017)... Ocala, FL (PRWEB) , ... February 17, 2017 ... ... of software tools that allow for the electronic prescribing of controlled and non-controlled ... , Ninety percent of pharmacies in the United States now accept electronic ...
(Date:2/17/2017)... ... 17, 2017 , ... Qualis Health, one of the nation's ... Annual DecisionHealth Platinum Awards in recognition of its innovative healthcare management programs that ... multiple award categories, highlighting four of the organization’s current programs:, ...
(Date:2/17/2017)... ... 2017 , ... PrideStaff, a national staffing organization, is pleased ... Industry Analysts' 2017 "Staffing 100 North America" list. , Now in its ... the staffing industry over the last twelve months. Industry insiders and observers nominate ...
(Date:2/17/2017)... ... 2017 , ... Dillon Ruxton Insurance, a Florida-based agency offering ... the greater Fort Lauderdale metropolitan region, is embarking on a cooperative food drive ... LifeNet 4 Families has provided a broad range of food provision services to ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... -- DaVita Inc. (NYSE: DVA ) today announced ... Net income attributable to DaVita Inc. for ... million, or $0.80 per share and $880 million, or $4.29 ... to DaVita Inc. for the quarter and year ended December ... million, or $0.98 per share, and $789 million, or $3.85 ...
(Date:2/16/2017)... ST. LOUIS , Feb. 16, 2017  Express Scripts (NASDAQ: ... one of the World,s Most Admired Companies within the Health Care: ... to be named one of the World,s Most Admired Companies," said ... is driven by the commitment and passion of our 26,000 employees ... people we serve." ...
(Date:2/16/2017)... , Feb 16, 2017 Research and Markets ... Diagnostics Market Analysis & Trends - Function, Application, Cancer Type, Technology ... ... Cancer Diagnostics Market is poised to grow at a CAGR of ... by 2025. Some of the prominent trends ...
Breaking Medicine Technology: