Navigation Links
Welders may be at increased risk for brain damage
Date:4/7/2011

Workers exposed to welding fumes may be at increased risk of damage to the same brain area harmed by Parkinson's disease, according to a new study by researchers at Washington University School of Medicine in St. Louis.

Fumes produced by welding contain manganese, an element that scientists have linked to neurological problems including Parkinson's disease-like symptoms.

"In the United States alone, there are more than 1 million workers who perform welding as a part of their jobs," says Brad Racette, MD, professor of neurology at Washington University School of Medicine. "If further investigation of this potential link between neurotoxic effects and these fumes proves it is valid, it would have a substantial public-health impact for the U.S. workforce and the economy."

The study appears online April 6, 2011, in Neurology, the medical journal of the American Academy of Neurology.

The study involved 20 welders with no symptoms of Parkinson's disease, 20 people with Parkinson's disease who were not welders and 20 people who were not welders and did not have Parkinson's. The welders were recruited from two shipyards and one metal fabrication company, and each had an average of 30,000 hours of lifetime welding exposure.

All participants were given brain PET and MRI scans and motor skills tests. A neurologist who specializes in movement disorders also examined all participants. The welders' average blood manganese levels were found to be two times the upper limits of normal blood manganese levels established in prior studies of general populations.

In one area of the brain, PET scans indicated that welders had an average 11.7 percent reduction in a marker of the chemical dopamine compared to people who did not weld. Dopamine helps nerve cells communicate and is decreased in specific brain regions in people with Parkinson's disease. The welders' motor skills test scores also showed mild movement difficulties that were not as extensive as those found in the early Parkinson's disease patients.

Although the same area of the brain was affected as in Parkinson's disease, the pattern of effects within this area was reversed. Parkinson's disease normally has the greatest impact on the rear of a structure known as the putamen. In the welders, the largest drop in the marker for dopamine occurred in a structure behind the putamen known as the caudate.

"While these changes in the brain may be an early marker of neuron death related to welding exposure, the damage appeared to be different from those of people with full-fledged Parkinson's disease," Racette says. "MRI scans also revealed brain changes in welders that were consistent with manganese deposits in the brain."

Racette and his colleagues plan a larger follow-up study to clarify the potential links between welding and brain damage.


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert  

Related medicine news :

1. Migraine Linked to Increased Heart Attack Risk
2. Attorney Joe Belluck Hails Department Of Defense For Increased Funding Of Mesothelioma Research
3. Increased HAART coverage associated with 50 percent drop
4. RetireSafe Survey Says Seniors Are Struggling With Increased Costs Without an Increased Social Security Cost of Living Adjustment
5. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
6. Increased Government Scrutiny of Companies That Use Independent Contractors, Consultants, or Freelancers: Are You Ready? Learn More at Complimentary Breakfast Briefing
7. Hormone thought to slow aging associated with increased risk of cancer death
8. Hormone replacement therapy linked to increased lung cancer risk
9. NACDS RxIMPACT "Hill Day" Features More Advocates Increased Focus on Medication Adherence
10. Weight-bearing exercise does not prevent increased bone turnover during weight loss
11. Increased radiation dose does not increase long-term side effects for prostate cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Welders may be at increased risk for brain damage
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
Breaking Medicine Technology: