Navigation Links
Weizmann Institute scientists show white blood cells move like millipedes
Date:5/4/2009

How do white blood cells immune system 'soldiers' get to the site of infection or injury? To do so, they must crawl swiftly along the lining of the blood vessel gripping it tightly to avoid being swept away in the blood flow all the while searching for temporary 'road signs' made of special adhesion molecules that let them know where to cross the blood vessel barrier so they can get to the damaged tissue.

In research recently published in the journal Immunity, Prof. Ronen Alon and his research student Ziv Shulman of the Weizmann Institute's Immunology Department show how white blood cells advance along the length of the endothelial cells lining the blood vessels. Current opinion maintains that immune cells advance like inchworms, but Alon's new findings show that the rapid movement of the white blood cells is more like that of millipedes. Rather than sticking front and back, folding and extending to push itself forward, the cell creates numerous tiny 'legs' no more than a micron in length adhesion points, rich in adhesion molecules (named LFA-1) that bind to partner adhesion molecules present on the surface of the blood vessels. Tens of these legs attach and detach in sequence within seconds allowing them to move rapidly while keeping a good grip on the vessels' sides.

Next, the scientists turned to the Institute's Electron Microscopy Unit. Images produced by scanning and transmission electron microscopes, taken by Drs. Eugenia Klein and Vera Shinder, showed that upon attaching to the blood vessel wall, the white blood cell legs 'dig' themselves into the endothelium, pressing down on its surface. The fact that these legs which had been thought to appear only when the cells leave the blood vessels are used in crawling the vessel lining suggests that they may serve as probes to sense exit signals. The researchers found that the shear force created by the blood flow was necessary for the legs to embed themselves. Without the thrust of the rushing blood, the white blood cells couldn't sense the exit signals or get to the site of the injury. These results explain Alon's previous findings that the blood's shear force is essential for the white blood cells to exit the blood vessel wall. The present study suggests that shear forces cause their adhesion molecules to enter highly active states. The scientists believe that the tiny legs are trifunctional: Used for gripping, moving and sensing distress signals from the damaged tissue.

In future studies, the scientists plan to check whether it is possible to regulate aggressive immune reactions (such as in autoimmune diseases) by interrupting the 'digging' of immune cell legs into the endothelium. They also plan to investigate whether cancerous blood cells metastasize through the blood stream using similar mechanisms in order to exit the blood vessels and enter different tissues.


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Related medicine news :

1. Weizmann Institute scientists create working artificial nerve networks
2. Weizmann Institute scientists new technique gets to the root of cancer
3. Weizmann Institute scientists discover how an injured embryo can regenerate itself
4. Weizmann Institute scientists develop a new approach to treating autoimmune disease
5. Weizmann Institute scientists produce the first smell map
6. Texas Cancer Organizations Urge State Legislature to Fully Fund the Cancer Prevention and Research Institute of Texas
7. Varicose Veins Pose Scary Health Risk; Sufferers Find Solace With Insurance-Covered Treatment at Renaissance Laser and Vein Institute
8. OHSU Knight Cancer Institute to study new radiation technology for head, neck cancer
9. Statement by Christine K. Cassel, MD, President and CEO of the ABIM Foundation on the Institute of Medicine Report: Conflict of Interest in Medical Research, Education, and Practice
10. ALS Therapy Development Institute Delivers Impassioned Testimony to Congressional Subcommittee on Veterans Affairs
11. Better Hearing Institute Joins HHS, Office on Women's Health in Promoting National Women's Health Week and Hearing Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... FlexiSpot, a trusted name ... free trial program for all of the company’s desktop riser products. A simple ... free experience. , FlexiSpot’s unique desktop risers use an advanced dual gas spring ...
(Date:12/2/2016)... PA (PRWEB) , ... December 02, 2016 , ... With ... struggling through rehabilitation of an injury, patients must find the one that works for ... his pain, he created a machine that worked and decided to share it with ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is ... USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that ... “We are prolonging life 6 years in the last 3 decades,” says Dr. ...
(Date:12/2/2016)... West Milford, NJ (PRWEB) , ... December 02, 2016 , ... ... Norway, Nothing Water has some unique properties including its unmatched natural purity of just ... described as clean and crisp. , Nothing Water has been available in several ShopRite ...
(Date:12/2/2016)... San Francisco, CA (PRWEB) , ... December 02, ... ... in digitally-enabled care journeys, announced today that it has raised $6.0 million in ... are inspired by Clarify Health’s conviction that patients and their caregivers can receive ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... , Dec. 3, 2016 Sickle cell ... rigid, sickle-shaped red blood cells that get stuck in ... pain, stroke, organ failure, and complications leading to death. ... born with SCD, and most of them lack access ... the only established long-term therapy for SCD, a pill ...
(Date:12/4/2016)... N.J. , Dec. 3, 2016  Findings ... and safety of CTL019, an investigational chimeric antigen ... (r/r) pediatric and young adult patients with B-cell ... during an oral session at the 58th American ... December 3, 4:00-5:30 p.m.). The global Phase II ...
(Date:12/2/2016)... - bioLytical lanza el INSTI HIV Self Test para el mercado ... Continue Reading ... New: INSTI Self Test! ... , bioLytical Laboratories (la "Compañía"), un líder mundial ... lanzamiento de su INSTI HIV Self Test  a África con una versión de ...
Breaking Medicine Technology: