Navigation Links
Weizmann Institute scientists reveal how tendons shape developing bones
Date:1/14/2010

Bones, muscles and tendons work together to provide the perfect balance between stability and movement in the skeleton. Now, Weizmann Institute scientists show that this partnership begins in the embryo, when the bones are still taking shape. The study, published in a recent issue of Developmental Cell, describes a previously unrecognized interaction between tendons and bones that drives the development of a strong skeletal system.

'Our skeleton, with its bones, joints and muscle connections serves us so well in our daily lives that we hardly pay attention to this extraordinary system,' says Dr. Elazar Zelzer of the Weizmann Institute's Molecular Genetics Department. 'Although previous research has uncovered mechanisms that contribute to the development and growth of each component of this complex and wonderfully adaptable organ system, specific interactions between bones, muscles and tendons that drive the assembly of the musculoskeletal system are not fully understood.'

Zelzer, research student Einat Blitz, Sergey Viukov and colleagues, were interested in uncovering the molecular mechanisms that regulate the formation of bone ridges bony protuberances that provide a stable anchoring point for the tendons that connect muscles with bones. Bone ridges are critical for the skeleton's ability to cope with the considerable mechanical stresses exerted by the muscles. The researchers used embryonic mouse skeletons to study a bone ridge called the deltoid tuberosity, located on the humerus bone in the arm.

They discovered, to their surprise, that rather than being shaped by processes within the skeleton, bone-ridge formation was directly regulated by tendons and muscles in a two-phase procedure. First, the embryonic tendons initiated bone-ridge formation by attaching to the skeleton. This interaction induced the tendon cells to express a specific protein called scleraxis, which in turn, led to the production of another protein, BMP4 a molecule involved in the onset of bone formation. Blocking BMP4 production in tendon cells prevented deltoid tuberosity bone ridge formation. In the second phase, the subsequent growth and ultimate size of the deltoid tuberosity was directly regulated by muscle activity.

The results demonstrate that tendons play an active role in initiating bone ridge patterning. Zelzer: 'These findings provide a new perspective on the regulation of skeletogenesis in the context of the musculoskeletal system, and they shed light on an important mechanism that underlies the assembly of this system.'


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Related medicine news :

1. Weizmann Institute scientists show white blood cells move like millipedes
2. Weizmann Institute scientists create working artificial nerve networks
3. Weizmann Institute scientists new technique gets to the root of cancer
4. Weizmann Institute scientists discover how an injured embryo can regenerate itself
5. Weizmann Institute scientists develop a new approach to treating autoimmune disease
6. Weizmann Institute scientists produce the first smell map
7. The Tech-Aid Institute Releases HIV/AIDS Prevention Software for Women with Intellectual Disabilities
8. Dr. Robert D. Willix Jr. M.D., CEO and CMO of Cenegenics(R) Medical Institute of Boca Raton Appointed Chief Medical Officer of Cenegenics(R) Medical Institute, Worlds Largest Preventive Age Management Practice
9. The Eye Institute of Utah Hosts World Renowned Cataract Surgeons: In Economically Trying Times, Nine Fortunate Patients Receive State of the Art Cataract Lenses
10. ALS Therapy Development Institute Receives $1.6 Million Grant From the Department of Defense for Lou Gehrigs Disease Research
11. Better Hearing Institute Publishes First Comprehensive Guide to Financial Assistance for Hearing Aids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... management assistance and financial planning services to families and business owners in northern ... event that promises to provide support to area adults with developmental challenges. , ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... selected to renovate and improve the Ramsey County Medical Examiners Facility located in ... Hospital, the $2.5 million project is scheduled to start in late 2017/early 2018. ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... and Theater of Witness , was awarded a $300,000 grant from ... program which fosters empathy, comfort with ambiguity and the recognition of one’s own ...
(Date:7/21/2017)... ... 2017 , ... Bernard R. Bach, Jr., MD, orthopaedic surgeon at Rush University ... of Sports Medicine (AOSSM) , received the 2017 Robert E. Leach Sports Medicine Leadership ... This prestigious award is given annually to honor those who have made a significant ...
(Date:7/21/2017)... ... July 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... of violence and aggression to solve problems and pleads with world leaders to be more ... forces do not bring peace. He says there is a peaceful and positive way to ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... 2017  BDI Group subsidiary Pathway Purchasing Network, ... organization serving specialty pharmacies, home infusion companies and ... significant, value-added member programs designed to help organizations ... and improve access and affordability for patients who ... Pathway has worked ...
(Date:7/10/2017)... , July 10, 2017 Locus Biosciences ... Note to support the development of CRISPR-Cas3 antimicrobial therapeutics. ... Limited, a leading Chinese Internet services provider, and joined ... advance multiple infectious disease product programs targeting antibiotic resistant ... Founded by Dr. Rodolphe Barrangou ...
(Date:7/5/2017)... , July 5, 2017 Wolfmet 3D ... answer as physics and manufacturing combine to progress molecular radiotherapy ... existing SPECT systems are unable to accurately quantify the radiation ... limited information regarding the success of this radiotherapy treatment has ... ...
Breaking Medicine Technology: