Navigation Links
Weizmann Institute scientists develop a new approach to treating autoimmune disease
Date:6/2/2008

In autoimmune diseases, the immune system turns against the body's own tissues and organs, wreaking havoc and destruction for no apparent reason. Partly because the origins of these diseases are so obscure, no effective treatment exists, and the suffering they inflict is enormous. Now Weizmann Institute scientists have developed a method that in the future may make it possible to treat autoimmune diseases effectively without necessarily knowing their exact cause. Their approach is equivalent to sending a police force to suppress a riot without seeking out the individuals who instigated the unrest.

In healthy people, a small but crucial group of immune cells called regulatory T cells, or T-regs, keeps autoimmunity in check, but in people with inflammatory bowel disease (IBD), one of the most common autoimmune disorders, too few of these cells appear in the diseased intestine, and the ones that do fail to function properly. The new Weizmann Institute approach consists of delivering highly selective, genetically engineered functioning T-regs to the intestine. The study was conducted by Dr. Eran Elinav, a physician from Tel Aviv Sourasky Medical Center's gastroenterology institute who is working toward his Ph.D. at the Weizmann Institute, and lab assistant Tova Waks, in the laboratory of Prof. Zelig Eshhar of the Immunology Department.

Relying on Eshhar's earlier work in which he equipped a different type of T cell to zero in on cancerous tumors, the team genetically engineered T-regs, outfitting these cells with a modular receptor consisting of three units. One of these units directed the cells to the intestine while the other two made sure they became duly activated. As reported in the journal Gastroenterology, the approach proved effective in laboratory mice with a disease that simulates human IBD: Most of the mice treated with the genetically-engineered T-regs developed only mild inflammation or no inflammation at all.

The cells produced what the scientists called a 'bystander' effect: They were directed to the diseased tissue using neighboring, or 'bystander' markers that identified the area as a site of inflammation, and suppressed the inflammatory cells in the vicinity by secreting soluble suppressive substances.

The scientists are currently experimenting with human T-regs for curing ulcerative colitis and believe that in addition to IBD, their 'bystander' approach could work in other autoimmune disorders, even if their causes remain unknown. They also think the method could be valuable in suppressing unwanted inflammation in diseases unrelated to autoimmunity, as well as in preventing graft rejection and certain complications in bone marrow and organ transplantation, in which inflammation is believed to play a major role.


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Related medicine news :

1. Weizmann Institute scientists produce the first smell map
2. OHSU Cancer Institute researchers find novel chemo drug helps treat prostate cancer
3. OHSU Cancer Institute researchers find many stomach cancer patients are not gertting best therapy
4. ECRI Institute Issues Priority Alert About Two Infusion Pumps
5. MedAssurants Dr. Keith Dunleavy to Present at AHIPs Institute 2008
6. Population Health Impact Institute Releases Methods Evaluation Process(TM) (MEP(TM)) Accreditation Standards for Public Comment Period
7. Worcester Polytechnic Institute announces 2008 Chairmans Exemplary Faculty Prize winners
8. Population Health Impact Institute to Host First Methods Evaluation Process(TM) (MEP(TM)) Workshop at Annual CMSA Conference
9. Presidential Candidates Health Care Plans Lack Key Reform Elements, Aspen Institute Finds
10. Institute for Integrative Nutrition Begins Road Tour
11. OHSU Cancer Institute researchers pinpoint how smoking causes cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... DeSoto, Kan. (PRWEB) , ... June 23, 2017 , ... ... Kan. , The restaurant is located at 4210 SW 21st St. Topeka, Kan. ... Brandon Graham, owner of Graham Restaurant Group who owns three other locations in the ...
(Date:6/23/2017)... ... 2017 , ... 21 Middle East and South Asia Leaders Selected as Eisenhower ... business and civil society in 11 countries across the Middle East and South Asia ... transformative exchange of knowledge and ideas with the leading minds in their fields. ...
(Date:6/23/2017)... ... 23, 2017 , ... American Farmer, will feature Chr. Hansen, Inc (CHR Hansen) ... fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check your local ... Hansen in Denmark in 1874 after a groundbreaking discovery of how to industrialize enzymes. ...
(Date:6/23/2017)... ... ... All-Star Insurance, a family managed agency that offers insurance management assistance and personal ... of a new charity drive to benefit women in the area diagnosed with breast ... estimated 252, 710 new cases of invasive or high risk breast cancer will be ...
(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is proud to ... for 2017. Each year, research and information firm, Castle Connolly, releases their list of ... 2015, this marks the 3rd time that Dr. Canales has been recognized ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... , June 7, 2017 Endo International ... June 7, 2017, the Hon. Joseph R. Goodwin ... of West Virginia , entered a ... Inc. Pelvic Repair System Products Liability Litigation (the "MDL") ... MDL cases to provide expert disclosures on specific causation ...
(Date:6/3/2017)... -- Eli Lilly and Company (NYSE: LLY ... 3 MONARCH 2 study showed that abemaciclib, a ... with fulvestrant, significantly improved progression-free survival (PFS) compared ... hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative ... progressed after endocrine therapy (median PFS, 16.4 vs. ...
(Date:5/30/2017)... Therapix Biosciences Ltd. (Nasdaq: TRPX), a ... development of cannabinoid-based drugs, today announced that the ... three upcoming scientific and investor conferences in June: ... ... Wednesday, June 7 ...
Breaking Medicine Technology: