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Weill Cornell team identifies potential new drug targets against hormone-dependent breast cancer
Date:2/28/2008

"We also validated the presence of this pathway in an animal model, the first time that's ever been done," Dr. Dannenberg notes.

The finding has many implications going forward. First of all, it adds valuable new information to the study of hormone-dependent breast cancer generally. "Pinpointing the role of these receptors is like adding two important new parts to the tumor's 'instruction kit.' You have to understand all the players involved if you hope to uncover weaknesses to fight or prevent the disease," Dr. Dannenberg says.

Finally, the receptors offer brand new targets for pharmaceutical research. "In fact, drugs that work against EP2 and EP4 ('antagonists') are already in development by pharmaceutical companies," Dr. Subbaramaiah says. "Our confirmation of the receptors' key role in regulating aromatase activity supports the further development of this form of targeted therapy."


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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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