Navigation Links
Weill Cornell team identifies new cancer stem cell driving metastatic tumors
Date:5/27/2008

NEW YORK (May 27, 2008) -- The molecular profile of cancer stem cells that initiate metastatic colon tumors is significantly different from those responsible for primary tumors, according to new research from a team at Weill Cornell Medical College.

Cancer researchers have long believed that a protein called CD133 identifies a population of cancer stem cells (so-called CD133+ cells), the only subset of cells that are responsible for tumor initiation. But in the experiment, in which immunocompromised mice were injected with human metastatic colon cancer, the Weill Cornell team discovered that cancer cells that do not express CD133 can also spur metastatic disease.

"In fact, metastatic tumors originating with these CD133- cells are more aggressive than those spurred by CD133+ cells," says study senior author Dr. Shahin Rafii, the Arthur B. Belfer Professor in Genetic Medicine and director of the Ansary Center for Stem Cell Therapeutics at Weill Cornell. Dr. Rafii is also a noted investigator at the Howard Hughes Medical Institute. "Our discovery shows that metastatic and primary cancer may not initiate in the same way. This could have significant implications for research going forward -- we believe the discovery opens up new avenues of investigation in cancer stem cell biology."

The findings were released as a special "highlighted" article in the May 22 online edition of the Journal of Clinical Investigation.

Cancer stem cells are a small, discrete class of cells that scientists believe give rise to malignancy and are solely responsible for tumor maintenance. For years, experts have tracked expression of the CD133 protein as a means of identifying a population of tumor-initiating cells.

To understand the biology of CD133+ cells in a healthy state and during tumor formation the researchers generated a transgenic mouse in which the CD133 gene is replaced with a reporter gene called lacZ. "We relied on the expression o
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Weill Cornell science briefs May 2008
2. NYP/Weill Cornell gene therapy clinical trial yields promising results for Batten disease
3. Weill Cornell Medical College Announces First Commencement of Its New Medical School Graduates in Doha, Qatar, May 8, 2008
4. Weill Cornell receives funding to study creation of new elder abuse center
5. Weill Cornell team identifies potential new drug targets against hormone-dependent breast cancer
6. $50 million gift to NewYork-Presbyterian Hospital/Weill Cornell Medical Center
7. NewYork-Presbyterian/Weill Cornell creates world-class cancer center
8. Weill Cornell receives $2.4 million in grants from Gates Foundation to fight tuberculosis
9. White House awards Weill Cornells Bruce McCandliss highest honor for early career scientists
10. The latest about male infertility and testosterone from NewYork-Presbyterian/Weill Cornell
11. NIH selects Weill Cornell Medical College to lead new NYC translational research collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... ... are in “a trending profession” that comprises a growing percentage of U.S. physicians, ... most. , That was one part of the message delivered by John W. ...
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders of ... the HOPE Movement of EvolvHealth. In what has been a long-term relationship between the ... their missions of purpose together to change the course of the network marketing industry. ...
(Date:8/1/2015)... ... , ... “ reTXT ” was featured on NewsWatch as part of its ... market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology ... and delete any message including ones already sent. , While text messaging has more ...
(Date:7/31/2015)... Ind. (PRWEB) , ... August 01, 2015 , ... The ... the Global Advisory Panel on the Future of Nursing (GAPFON) 20-21 July 2015 in ... invited to participate in this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied ...
(Date:7/31/2015)... Alexandria, VA (PRWEB) , ... July 31, 2015 ... ... Foundation) introduced its new store run by GoodThreads. The store can be accessed ... products and designs, many of which are customizable. The best part: whenever a ...
Breaking Medicine News(10 mins):Health News:COMP-Northwest Welcomes Class of 2019 2Health News:COMP-Northwest Welcomes Class of 2019 3Health News:COMP-Northwest Welcomes Class of 2019 4Health News:COMP-Northwest Welcomes Class of 2019 5Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3
... Foundation Applauds Patient Education In New National Guidelines, ... children and adults with asthma are getting a back-to-school ... U.S. health,officials, which affirm the primary importance of patient ... live without limits and,to improve their quality of life., ...
... report that exercise and yoga can help maintain ... in women with early-stage breast cancer. The first ... physical fitness, self-esteem and body composition, and that ... study demonstrated that yoga was particularly beneficial for ...
... Healthcare Technology Executive Brings Over 20 Years Of Experience ... in Sales, Marketing And Operational Excellence, ... (Nasdaq: MEDW ) announced the appointment of Thomas ... joins Mediware,following more than 20 years with 3M,s healthcare ...
... The results of a clinical trial, published in ... when used as part of routine therapy, high-dose ibuprofen ... in children with cystic fibrosis (CF). , Headed by ... Montreal Childrens Hospital of the McGill University Health Centre, ...
... Inc. (Nasdaq and SWX: BMRN) announced today that Emil,Kakkis, ... a,company update at the Bear Stearns 20th Annual Healthcare ... at 3:00 p.m. ET. Interested parties may access ... section of the BioMarin website, http://www.BMRN.com . A,replay ...
... a new study indicate a strong link between the ... cognitive impairment (MCI), often a harbinger of Alzheimer,s disease. ... binds specific substances. Researchers found reduced levels of LR11, ... tissue of people diagnosed with MCI. In addition, the ...
Cached Medicine News:Health News:School is Cool for Asthma Patients of All Ages 2Health News:Exercise and yoga improves quality of life in women with early-stage breast cancer 2Health News:Exercise and yoga improves quality of life in women with early-stage breast cancer 3Health News:Mediware Names Thomas K. Mann Chief Executive Officer 2Health News:Low level of neuronal receptor linked to mild cognitive impairment and Alzheimer's disease 2
(Date:7/30/2015)... IRIDEX Corporation (NASDAQ: IRIX ) today ... financial results after the market closes on Thursday, ... the Company will host a conference call with the ... Thursday, August 6, 2015 to discuss ... Interested parties may access the live conference ...
(Date:7/30/2015)... 2015  EP Global Communications, Inc. (Public OTC: EPGL) announced ... the Company about discussing EPGL,s electronic contact lens ... August 3, 2015.  Novartis CEO Joe Jimenez ... coming electronic contact lens market could be worth ... several years.  Novartis partnered with Google in 2014 ...
(Date:7/30/2015)... BOTHELL, Wash. and VANCOUVER ... OGXI ) announced today that it will report ... 13, 2015. Company management will host a conference call ... provide an overview of financial results, clinical development programs ... access the webcast, log on to the Investor Relations ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2
... a leading designer of integrated medical imaging display systems, ... Medical achieved significant growth in sales, an expansion of ... Carrot Medical, recognized as a market leader, is the ... medical images and other visual data onto a single, ...
... Pharmaceuticals International, Inc. (NYSE: VRX ) (TSX: ... ("Valeant"), its wholly owned indirect subsidiary, launched its offer ... unsecured notes (the "Notes"). The Notes will ... as amended (the "Securities Act"), or any state securities ...
Cached Medicine Technology:Carrot Medical Reports 2010 Growth in Sales and Financing, Optimism for 2011 2Valeant Launches Senior Notes Offering 2Valeant Launches Senior Notes Offering 3
For vacuum-driven processing of spin columns; Reduced sample handling and accelerated processing; Parallel sample processing using QIAGEN spin columns; Easy cleaning of internal components by simpl...
Inquire...
... allows processing of up to 24 spin columns in ... columns into and out of a centrifuge. The ... savings rapid vacuum-driven purification and cleanup of ... Convenience minimal hands-on-time ...
... Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen Blow-Down Evaporators. For over ten years ... ... ... ...
Medicine Products: