Navigation Links
Weill Cornell presents updated results from Phase 3 trial of IVIG for Alzheimer's disease
Date:7/16/2013

NEW YORK (July 16, 2013) -- Weill Cornell Medical College neurologist Dr. Norman Relkin reported new findings today from the Phase 3 clinical trial of IVIG (intravenous immunoglobulin) in mild to moderate Alzheimer's disease at the Alzheimer's Association International Conference (AAIC) in Boston, Mass. While the primary study outcomes were negative, observations from the subgroup analyses include whether there may be a dose-dependent reduction of beta amyloid in the blood and brain of IVIG-treated Alzheimer's patients who have the ApoE4 genotype.

IVIG is a mixture of antibodies derived from the blood of healthy donors. Given its ability to control infection and inflammation, IVIG has been used to treat disease for more than 30 years. It has been approved for use in treating several disorders, ranging from pediatric immune disorders to a blood cancer and Kawasaki disease, but is not approved for Alzheimer's disease.

The Gammaglobulin Alzheimer's Partnership (GAP) Study was a Phase 3, randomized, double-blind, placebo-controlled clinical trial in 390 people with mild to moderate Alzheimer's disease, conducted at 45 centers in the U.S. and Canada. Two different doses of IVIG were tested versus placebo as add-ons to approved Alzheimer's medications. The drug was administered every two weeks for 18 months. Primary study endpoints were changes on two well-established tests of cognition and daily functioning -- the ADAS-Cog and ADCS-ADL.

In a topline announcement in May, the GAP researchers reported negative results on the GAP study's primary outcomes -- the ADAS-Cog and ADCS-ADL. At the same time, preliminary observations were reported on favorable changes on another cognitive test, the Modified Minimental State Examination (3MS) in two subgroups: people with Alzheimer's who carried the APOE-e4 Alzheimer's risk gene, and those who were moderately impaired. The study was not powered to show statistical significance in these pre-planned
'/>"/>

Contact: John Rodgers
pr@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Weill Cornell Medical College establishes Center for Healthcare Informatics and Policy
2. Weill Cornell awarded $1.8 million for translational blood cancer research
3. Weill Cornell receives $1.5 million in Grand Challenges Explorations grants
4. New Institute for Precision Medicine created at Weill Cornell and NewYork-Presbyterian
5. Weill Cornell Medical School Teams with MediGait to Get the Elderly, Sufferers of Parkinson’s and Multiple Sclerosis “Back on their Feet”
6. Dr. Augustine M. K. Choi Appointed Chairman of Medicine at Weill Cornell Medical College and Physician-in-Chief at NewYork-Presbyterian/Weill Cornell Medical Center
7. Second annual Brain Tumor Biotech Summit 2013 at Weill Cornell
8. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
9. Cornell Dubilier Launches New Website with Advance Capacitor Search
10. Cornell Dubilier Announces Long-Life Ultracapacitors
11. CareAnyware and Cornell University Partner to Help Reduce Rehospitalizations by 39% in Clinically Depressed Home Health Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... (PRWEB) September 20, 2014 Earlier this week, ... customers may have had their credit card information pilfered by ... spawning a slew of headline articles like this one ... the only eye opening numbers. , “Most people tend ... almost like it’s a way to score a game,” says ...
(Date:9/20/2014)... The first federal bellwether trial of a ... week in the U.S. District Court, Northern District of ... that the week opened in the DePuy Pinnacle ... Orthopaedics vice president, who discussed the clinical testing performed ... replacement. According to Reuters, the executive stated that the ...
(Date:9/19/2014)... September 20, 2014 Consistent premium ... for the Vision Insurance industry in recent years; ... detriment of industry margins. From 2009 to 2014, ... operators provide coverage for routine eye exams and ... eyeglasses, contact lens and refractive surgery. According to ...
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- As kids transition from ... of cyberbullies, according to a recent study. ... through 8 found that verbal and physical bullying declines ... bullying intervention and prevention strategies must address all types ... boys and girls, the researchers said. The study was ...
(Date:9/19/2014)... 19, 2014 Visiting Nurse Association (VNA) ... health care, hospice and palliative care and community-based care, ... Opening Bell yesterday at the New York Stock Exchange. ... and social entrepreneur to care for immigrant families suffering ... always worked to meet the urgent healthcare needs of ...
Breaking Medicine News(10 mins):Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 2Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 3Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News: Cyberbullying Seems to Ramp Up in Middle School 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3
... and laboratory rodents seems to throw light on the aspect ... the environment, rather than protecting against it. ... systems of mice and rats which live in laboratories with ... researcher William Parker said, "Laboratory rodents live in a virtually ...
... and Dr. John Read, from the University of Auckland, ... and Madrid about the link between child abuse which ... psychiatric patients and found that they were sexually or ... studies of schizophrenics, they found that the abuse rates ...
... brought into New Zealand by scientists to clarify with the ... laboratory holds the threatening substance for testing it with the ... the Wallaceville manager said it has been imported from Australia ... Well-trained staffs, wearing safe suits are engaged to deal with ...
... system paralysis:,Sir Ian: "There is an urgent timetable, you are right. ... the most challenging in the history of the NHS - because ... our annual report ... and we need to meet the challenge ... is really demanding - and on top of that we need ...
... Health Minister Anbumani Ramadoss Friday warned of "strong action" ... All India Institute of Medical Sciences// (AIIMS), saying a ... hub". ,"Some people have converted the AIIMS into ... them when I return to New Delhi June 19," ...
... new guidelines on obesity finalized to cause harm to ... overweight//. ,Due to financial agreements made between ... an unfit guideline was being made to harm children ... ,The article outlines how an influential expert ...
Cached Medicine News:Health News:NHS acting chief’s intervie 2Health News:New Obesity Guidelines Will Trouble US Children 2
(Date:9/19/2014)... 19, 2014 Five MinuteClinic walk-in medical clinics are opening ... metropolitan area. Three clinics opened in Memphis ... clinic will be added in Springfield on ... is expected to open October 22.  MinuteClinic is the largest ... the United States . The Memphis ...
(Date:9/19/2014)... 19, 2014  Alere Inc. (NYSE: ALR ... following statement today in support of President Barack ... "As the global leader in rapid diagnostics for infectious ... strategy to address the serious threat of antibiotic resistance. ... Administration on initiatives to promote the development of rapid ...
(Date:9/19/2014)... -- BioSpecifics Technologies Corp. (NASDAQ: BSTC ), a biopharmaceutical ... ® in the U.S. and XIAPEX ® in ... , will present a corporate overview at the 21 st ... The presentation will take place on Friday, September ... Hotel in New York, NY . A ...
Breaking Medicine Technology:MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2
... SAN FRANCISCO, Oct. 1 Merriman Curhan Ford Group, ... advisor to TorreyPines Therapeutics, Inc. in the recent merger ... , The combined company is named "Raptor Pharmaceutical Corp." ... NASDAQ Capital Market under the ticker symbol "RPTP." , ...
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) today announced ... payment of $0.50 per share to all stockholders owning shares ... previously announced, the conversion rate for the Company,s 2.00% Convertible ... shares of common stock per $1,000 principal amount, as a ...
Cached Medicine Technology:Merriman Curhan Ford Acted as Financial Advisor to TorreyPines Therapeutics, Inc. in the Completed Merger With Raptor Pharmaceuticals Corp. 2
... Universal Torso Shoulder Immobilizer A ... 3/8" foam with contact closure. ... posteriorly. Movable wrist cuff. Plastic ... strap. Shoulder strap may adjust ...
... Brace is designed for the functional management ... separations. Using a pre-inflated aircell, the brace ... joint while supporting the arm and shoulder. ... AC Sport Brace for additional arm support ...
... Humerus Fracture Brace indications: , Nonoperative treatment ... Postoperative treatment of open humeral shaft fractures ... , After removal of internal or external ... Defects resulting from tumor growth , ...
Controls humeral segments through soft tissue compression while allowing for full range of elbow motion...
Medicine Products: