Navigation Links
Weill Cornell presents updated results from Phase 3 trial of IVIG for Alzheimer's disease
Date:7/16/2013

NEW YORK (July 16, 2013) -- Weill Cornell Medical College neurologist Dr. Norman Relkin reported new findings today from the Phase 3 clinical trial of IVIG (intravenous immunoglobulin) in mild to moderate Alzheimer's disease at the Alzheimer's Association International Conference (AAIC) in Boston, Mass. While the primary study outcomes were negative, observations from the subgroup analyses include whether there may be a dose-dependent reduction of beta amyloid in the blood and brain of IVIG-treated Alzheimer's patients who have the ApoE4 genotype.

IVIG is a mixture of antibodies derived from the blood of healthy donors. Given its ability to control infection and inflammation, IVIG has been used to treat disease for more than 30 years. It has been approved for use in treating several disorders, ranging from pediatric immune disorders to a blood cancer and Kawasaki disease, but is not approved for Alzheimer's disease.

The Gammaglobulin Alzheimer's Partnership (GAP) Study was a Phase 3, randomized, double-blind, placebo-controlled clinical trial in 390 people with mild to moderate Alzheimer's disease, conducted at 45 centers in the U.S. and Canada. Two different doses of IVIG were tested versus placebo as add-ons to approved Alzheimer's medications. The drug was administered every two weeks for 18 months. Primary study endpoints were changes on two well-established tests of cognition and daily functioning -- the ADAS-Cog and ADCS-ADL.

In a topline announcement in May, the GAP researchers reported negative results on the GAP study's primary outcomes -- the ADAS-Cog and ADCS-ADL. At the same time, preliminary observations were reported on favorable changes on another cognitive test, the Modified Minimental State Examination (3MS) in two subgroups: people with Alzheimer's who carried the APOE-e4 Alzheimer's risk gene, and those who were moderately impaired. The study was not powered to show statistical significance in these pre-planned
'/>"/>

Contact: John Rodgers
pr@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Weill Cornell Medical College establishes Center for Healthcare Informatics and Policy
2. Weill Cornell awarded $1.8 million for translational blood cancer research
3. Weill Cornell receives $1.5 million in Grand Challenges Explorations grants
4. New Institute for Precision Medicine created at Weill Cornell and NewYork-Presbyterian
5. Weill Cornell Medical School Teams with MediGait to Get the Elderly, Sufferers of Parkinson’s and Multiple Sclerosis “Back on their Feet”
6. Dr. Augustine M. K. Choi Appointed Chairman of Medicine at Weill Cornell Medical College and Physician-in-Chief at NewYork-Presbyterian/Weill Cornell Medical Center
7. Second annual Brain Tumor Biotech Summit 2013 at Weill Cornell
8. Penn and Cornell researchers spearhead the development of new guidelines for veterinary CPR
9. Cornell Dubilier Launches New Website with Advance Capacitor Search
10. Cornell Dubilier Announces Long-Life Ultracapacitors
11. CareAnyware and Cornell University Partner to Help Reduce Rehospitalizations by 39% in Clinically Depressed Home Health Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... IQ Formulations , a top national health ... Inc. 500 , distinguishing it as one of the fastest ... only made the list, but was ranked in the top ... three years. It also ranked ninth among all health companies, ... second fastest growing company in the Miami metro area. ...
(Date:8/20/2014)... BCC Research ( http://www.bccresearch.com ) ... AND DETECTORS: TECHNOLOGIES AND GLOBAL MARKETS , the ... to grow to $15.2 billion by 2019, with ... 15.9%. Increasing industrialization is driving significant growth ... expanding range of industrial applications such as military ...
(Date:8/20/2014)... 2014 It’s no secret that millions ... the National Institute on Drug Abuse, nearly 24 million ... even more alarming is the fact that the total ... , Those locked in a struggle with substance abuse ... But now, the newly-redesigned AbuseTreatmentCenters.net has released updated lists ...
(Date:8/20/2014)... York, NY (PRWEB) August 20, 2014 ... Awards. PM360, a leading health-marketing industry trade magazine, will ... 2009, the Trailblazer Awards are given to outstanding companies, ... has to offer. , “We are proud to ... our call to entries with double the number of ...
(Date:8/20/2014)... York, NY (PRWEB) August 20, 2014 ... world’s largest nutrition school, is proud to announce ... Integral Studies (CIIS), a cutting-edge university offering ... Nutrition’s Health Coach Training Program are now eligible ... of Arts in Integrative Health Studies. , “I’m ...
Breaking Medicine News(10 mins):Health News:Leading Health Supplement Company IQ Formulations Among Inc. Magazine’s Top 50 Fastest Growing Private Companies in the United States 2Health News:Global Market for Photonic Sensors and Detectors to Reach $15.2 Billion in 2019 2Health News:Global Market for Photonic Sensors and Detectors to Reach $15.2 Billion in 2019 3Health News:Re-Launched AbuseTreatmentCenters.net Offering New List of Substance Abuse Resources 2Health News:PM360 Announces 2014 Trailblazer Award Finalists 2Health News:PM360 Announces 2014 Trailblazer Award Finalists 3Health News:PM360 Announces 2014 Trailblazer Award Finalists 4Health News:PM360 Announces 2014 Trailblazer Award Finalists 5Health News:PM360 Announces 2014 Trailblazer Award Finalists 6Health News:PM360 Announces 2014 Trailblazer Award Finalists 7Health News:PM360 Announces 2014 Trailblazer Award Finalists 8Health News:Integrative Nutrition Announces New Partnership with California Institute of Integral Studies 2Health News:Integrative Nutrition Announces New Partnership with California Institute of Integral Studies 3
... cohort studies on the association of alcohol consumption with colorectal ... 2 from Australia, 13 from Western Europe, and 24 from ... least at higher levels of consumption, is associated with an ... was no increase in the risk for consumers reporting an ...
... , TUESDAY, Sept. 13 (HealthDay News) --The lifestyle changes ... disease may also improve sexual function in men with ... from the Mayo Clinic in Rochester, Minn., analyzed six ... determine how lifestyle changes and drugs used to treat ...
... for an effective vaccine and treatment against the potentially fatal ... the discovery of two ,Achilles, heels, within the virus. ... South Wales (UNSW) studied individuals at high risk of HCV ... the onset of infection. Using a new technique ...
... Canadian researchers has found the first evidence that lifelong ... While hearing studies have already shown that trained musicians ... is the first study to examine hearing abilities in ... 18 to 91 years of age. The study ...
... HealthDay Reporter , MONDAY, Sept. 12 (HealthDay News) -- ... become fathers, perhaps because they don,t need to compete with ... with their children. The findings don,t prove that fatherhood ... hormonal systems in men may detect that they,ve become fathers ...
... MONDAY, Sept. 12 (HealthDay News) -- Implantable electronic devices ... heart conditions and save lives, but these benefits may ... complications, a new study suggests. Researchers from the ... that people who develop an infection related to a ...
Cached Medicine News:Health News:Relation of alcohol consumption to colorectal cancer 2Health News:Breakthrough opens new avenues for hep C vaccine 2Health News:Science finding is music to the ears 2Health News:Testosterone Levels Seem to Fall With Fatherhood 2Health News:Testosterone Levels Seem to Fall With Fatherhood 3Health News:Heart Devices Like Pacemakers Linked to Infections 2
(Date:8/19/2014)... Corporation,s Orthopaedics Division, the Official Joint Replacement Products of the ... joint health to golf fans in its home state of ... Barclays.  The company,s fan destination – "The Stryker Mobility Zone" ... th fairway at the Ridgewood Country Club in ... .    At The Barclays, Stryker will be ...
(Date:8/19/2014)... , August 19, 2014 ... a clinical-stage pharmaceutical company focused on the development ... the Intellectual Property Department of Spain ... its invention, titled "Methods and Compositions for Oral ... Oramed Pharmaceuticals is a technology pioneer ...
(Date:8/19/2014)... 19, 2014 Research and Markets has ... Strategic Business Report" report to their offering. ... in US$ Thousands by the following three major Application Areas: ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ...
Breaking Medicine Technology:Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 2Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 3Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 4Stryker, The Official Joint Replacement Products Of The PGA TOUR, Welcomes Golf Fans To Its Home State Of New Jersey For The Barclays 5Oramed Granted Patent in Spain for Oral Administration of Insulin 2Oramed Granted Patent in Spain for Oral Administration of Insulin 3Global Anti-Adhesion Products - Strategic Business Report 2014 2
... SAN DIEGO, Sept. 29, 2011 Awarepoint ... system (RTLS) solutions for healthcare, announced today that ... (RFID) and RTLS Healthcare Competitive Strategy Leadership ... pioneering and providing complete RTLS and workflow automation ...
... 2011 Terumo Americas Holdings, Inc., a U.S. subsidiary ... Terumo Corporation,s founding in 1921.  Terumo Corporation is one ... billion in annual sales and operations in more than ... magazine ranked Terumo Corporation 14th of the top 100 ...
Cached Medicine Technology:Awarepoint Corporation Receives Frost & Sullivan's 2011 North American RFID and RTLS Healthcare Competitive Strategy Leadership Award 2Awarepoint Corporation Receives Frost & Sullivan's 2011 North American RFID and RTLS Healthcare Competitive Strategy Leadership Award 3Terumo Corporation, A Global Leader In Medical Device Technology, Celebrates 90th Anniversary 2Terumo Corporation, A Global Leader In Medical Device Technology, Celebrates 90th Anniversary 3
Penfield Dissector #1...
ScalpFix scalp clip system includes an reusable handle, scalp clips, sterile packed cartridges and removal forceps. It is easy to use, time saving and fast application....
Disposable scalp clip applier, comes loaded with 12 Leroy-Raney clips, ergonomic, easy to handle and position the clip....
... Multifunctional instrumentation, capable of ... tissue by means of ultra-sonic ... on organs, and, in particular, ... advantages of tissue-selection and non-traumatic ...
Medicine Products: