Navigation Links
Weight-loss surgery can reduce liver damage
Date:5/4/2014

Chicago, IL (May 4, 2014) Bariatric surgery, which is best known for its ability to help patients lose substantial weight, can also result in significant improvement in nonalcoholic fatty liver disease (NAFLD), according to new research presented today at Digestive Disease Week (DDW). Researchers at the University of South Florida-Tampa found that bariatric surgery resolved liver inflammation and reversed early-stage liver fibrosis, the thickening and scarring of liver tissue, by reducing fat deposits in the liver.

"About 30 percent of the U.S. population suffers from this disease, which is increasing, and more than half are also severely obese," said Michel Murr, MD, lead researcher of the study, professor of surgery and director of Tampa General Hospital and USF Health Bariatric Center. "Our findings suggest that providers should consider bariatric surgery as the treatment of choice for nonalcoholic fatty liver disease in severely obese patients."

Dr. Murr and his colleagues suggest that bariatric surgery be considered for patients with a body mass index greater than 35 and obesity-related co-morbidities, or a body mass index of greater than 40. They note that traditional interventions, such as medications, have a low success rate with these patients.

Researchers compared liver biopsies from 152 patients one at the time of the bariatric procedure and a second an average of 29 months afterwards. In examining pre-operative biopsies, researchers identified patients with cellular-level manifestations of nonalcoholic fatty liver disease, specifically, fat deposits and inflammation of the liver. These types of liver damage can lead to liver fibrosis and cirrhosis, which can be life-threatening.

After reviewing post-operative biopsies, they found that bariatric surgery resulted in improvements for these patients. In the post-operative biopsies, researchers found that fat deposits on the liver resolved in 70 percent of patients. Inflammation was also improved, with lobular inflammation resolved in 74 percent of patients, chronic portal inflammation resolved in 32 percent, and steatohepatitis resolved in 88 percent.

In addition to these improvements, 62 percent of patients with stage two liver fibrosis had an improvement or resolution of the fibrosis. One of three patients with cirrhosis also showed improvement. Dr. Murr noted that these findings on fibrosis reversal apply only to early-stage fibrosis, and not late-stage liver disease.

"We are in the midst of an obesity epidemic that can lead to an epidemic of nonalcoholic fatty liver disease," said Dr. Murr. "As a tool in fighting obesity, bariatric surgery could also help prevent the emergence of widespread liver disease."

Dr. Michel Murr will present data from the study "Bariatric surgery improves histological features of nonalcoholic fatty liver disease and liver fibrosis," abstract 233, on Sunday, May 4, at 8:30 a.m. CT, in room S504BCD of McCormick Place. For more information about featured studies, as well as a schedule of availability for featured researchers, please visit http://www.ddw.org/press.


'/>"/>

Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
Digestive Disease Week
Source:Eurekalert

Related medicine news :

1. Slim pickings for 2 weight-loss drugs?
2. The Federal Trade Commission Files Lawsuit Seeking an Injunction Against Marketer of Weight-loss Products Over Alleged False Advertising, Parker Waichman LLP Reports
3. Medicare Center of Excellence Policy may limit minority access to weight-loss surgery
4. San Jose Woman Turns Life Around After Weight-Loss Surgery
5. Man’s Big Weight-Loss Plan Tailored With Skinny Limit’s Help
6. Weight-Loss Surgery May Help Moderately Obese, Too
7. Womens Weight-Loss Surgery May Benefit Later Offspring
8. SENSA® Weight-Loss System Now Available at Defense Commissary Agency Locations Nationwide
9. Beyond Rules—Sean A. Anderson’s Remarkable 275 Pound Weight-Loss Approach Now on Paperback and E-book
10. Gene Test May Help Predict Success of Weight-Loss Surgery
11. Study Supports Broader Access to Lap-Band Weight-Loss Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... July 19, 2017 , ... Dr. Jig Patel is pleased to announce openings ... without a referral. Understanding the difficulties that face people who are missing teeth ... permanent alternative to removable dentures and bridges. Not only does an implant improve oral ...
(Date:7/20/2017)... ... 19, 2017 , ... Western University of Health Sciences College ... grant to train predoctoral dental students in providing care to vulnerable children ages ... , The Predoctoral Pediatric Training Project (PPTP), a five-year grant, recognizes the curriculum ...
(Date:7/20/2017)... ... July 19, 2017 , ... A July ... lead to, or worsen, varicose veins in some patients, according to medical experts. ... certain not-so-good practices, like excessive sitting or standing, or regularly nicking yourself while ...
(Date:7/18/2017)... ... 2017 , ... CannaKids, a California Cooperative Cooperation that specializes in the creation ... WORLDZ Summit, taking place in Hollywood from July 31-August 1, the Company’s Founder ... for both pediatric and adult patients, and how the path has led her to ...
(Date:7/18/2017)... , ... July 18, 2017 , ... The results of an international clinical trial, led ... therapy for a severe type of muscular dystrophy holds promise for a subgroup of patients. ... Craig McDonald and colleagues at 53 study sites in 18 countries describe the clinical ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... , July 12, 2017 CarpalAID is a revolutionary new ... or surgery. Carpal tunnel syndrome affects more than 8 ... twice the rate of men. The common methods of treating CTS ... with uncomfortable hand braces or gloves. ... CarpalAID is a clear patch worn ...
(Date:7/11/2017)... July 11, 2017  Sysmex America, Inc., a ... testing equipment as well as middleware information systems ... to make quality assurance easier and more risk ... well known for the innovation that it delivers ... elevates quality assurance processes to a new level ...
(Date:7/10/2017)...  BDI Group subsidiary Pathway Purchasing Network, a ... serving specialty pharmacies, home infusion companies and physician ... value-added member programs designed to help organizations gain ... improve access and affordability for patients who rely ... Pathway has worked with ...
Breaking Medicine Technology: