Navigation Links
Weight-loss proves effective cure for sleep apnea

For obese men, a dramatic weight loss can be an effective way to improve moderate to severe sleep apnoea, scientists at the Swedish medical university Karolinska Institutet report. Those with severe sleep apnoea when the study began benefited most from weight loss.

"Our findings suggest that weight loss may be an effective treatment strategy for sleep apnoea in obese men," says Kari Johansson, one of the researchers involved in the study.

Sleep apnoea the temporary cessation of breathing during sleep is a relatively common but under-diagnosed disease. Five or more such events per hour is considered a disease. Untreated, sleep apnoea is associated with an increased risk of traffic accidents, as well as stroke and heart disease, for example. Moderate and severe sleep apnoea also increases the risk of premature death. It has long been known that people with overweight or obesity are more likely to develop the disease, and that men are more affected than women.

In a randomised study published in the British Medical Journal, researchers at Karolinska Institutet examined if weight-loss can help to cure moderate and severe sleep apnoea. The study included 63 obese men (BMI between 30 and 40) aged between 30 and 65. The participants had moderate to severe sleep apnoea as measured by the AHI (apnoea-hypopnea) index. All participants had symptom alleviation treatment through CPAP continuous positive airway pressure which produces more normal breathing patterns during sleep. The participants were randomly assigned to two groups, one of which underwent an intense weight-loss programme, the other served as a control group, for a period of nine weeks.

The results of the study show that the weight loss group lost 19 kilos on average after nine weeks and more than halved the number of apnoea events. None of the treated patients had severe sleep apnoea, half had only mild sleep apnoea and one in six could be declared healthy. The researchers also noted that the effect of the weight loss programme was greatest in patients with severe sleep apnoea.

To achieve significant weight loss, the treatment group were put on a very low calorie diet (VLCD), which gave them an initial energy input of 554 kcal per day for seven weeks followed by a fortnight's successive increase up to 1,500 kcal per day at week nine. The control group maintained their normal dietary habits during the nine week study period, but was afterwards offered a VLCD programme.

After the VLCD period, the participants were also invited to take part in a year's behavioural change programme to help them maintain their weight loss.

"We often use VLCD in the form of a low calorie powder as part of the treatment of obese patients with a serious comorbidity, such as sleep apnoea," says Ms Johansson. "The powder is mixed with water and replaces every meal of the day, which gives a rapid loss of weight. It's also a good way of boosting the patients' motivation."

The researchers stress that the VLCD diet is not a general solution to weight problems, but something mainly to be used in the first phase of a long-term treatment programme. To keep the weight off, patients need to work hard to improve their dietary and exercise habits, usually with the aid of a long-term behaviour modification programme. Drugs can also be used in the post-weight loss phase to further improve weight loss maintenance.

The current study was part funded by Cambridge Manufacturing Company Limited, which markets the Cambridge Diet, the low-calorie powder used in the study. The company had no influence on the study, the analyses or the collation of the results. Examples of similar VLCD products marketed by other companies are Nutrilett, Naturdiet and Allevo. The researchers who conducted the study work at the Obesity Unit, Karolinska University Hospital, Huddinge, and the Clinical Epidemiology Unit, Karolinska Institutet.


Contact: Katarina Sternudd
Karolinska Institutet

Related medicine news :

1. SENSA(R) WEIGHT-LOSS PROGRAM: The Accidental Discovery Thats Transforming The Way People Lose Weight Breaks the Top 500 at in Less Than Two Weeks of Publication
2. New Product Launch - SAFFRENE Delivers Impressive Mood Elevation and Weight-loss Benefits
3. Delaying Weight-Loss Surgery May Leave Teens at Risk
4. Weight-Loss Surgery Breaks Families Obesity Cycle
5. FDA Investigating Weight-Loss Drug Over Reports of Liver Damage
6. Study Finds Weight-Loss Surgery Safer Than Thought
7. Weight-Loss Enzyme Identified
8. Jillian Michaels, Americas Toughest Trainer, Announces New Line of Weight-Loss Supplements
9. Obese Poor Shut Out From Weight-Loss Surgeries
10. Weight-Loss Surgery Safe, Effective Type 2 Diabetes Treatment
11. Common Weight-Loss Surgery May Double Risk of Kidney Stones
Post Your Comments:
(Date:11/26/2015)... ... 26, 2015 , ... Pixel Film Studios brings Final Cut ... Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired designs, with ... users limitless opportunities to stylize and create designs quickly and easily, all within ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... accessible for all, Water For Empowerment ™ attracts volunteers together who want ... water by empowering women as key stakeholders in the process. The non-profit launched ...
(Date:11/25/2015)... Cokato, MN (PRWEB) , ... November 25, 2015 ... ... manufacturer, launched offering factory direct sauna parts and accessories. , Sauna accessories ... representative of the bather’s style and personality. From basic styles for the purist ...
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
(Date:11/25/2015)... OK (PRWEB) , ... November 25, 2015 , ... On ... International training center for the Narconon network, announced the release of a new cutting ... 1966 the Narconon organization has been working with drug- and alcohol-addicted individuals with the ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... STOCKHOLM , November 26, 2015 ... the potential to use SyMRI to find optimal contrast weighting ... brain tumor metastases, and has signed a research agreement with ... at the hospital. Using SyMRI, it is possible to generate ... parameter settings after the patient has left, thus making it ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... Cardiac Pacemaker Market Outlook to 2019 - Rise in Cardiac ... " report to their offering. ... Boston scientific and others. --> ... Medtronic, Biotronik, Boston scientific and others. ...
(Date:11/26/2015)... -- 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ... transplantation is expected to boost the market growth, as 3D ... --> 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ...
Breaking Medicine Technology: