Navigation Links
Weight loss improves fatty liver disease, researchers find
Date:2/17/2009

ST. LOUIS In a recent study, Saint Louis University researchers found that weight loss of at least 9 percent helped patients reverse a type of liver disease known as nonalcoholic steatohepatitis (NASH), a finding that will allow doctors to give patients specific weight-loss goals that are likely to improve their livers. The finding comes from a study of the diet drug orlistat (also known as Xenical and Alli), which did not itself improve liver disease.

Brent Neuschwander-Tetri, M.D., a hepatologist at Saint Louis University Liver Center and study researcher said, "It's a helpful study because we can now give patients a benchmark, a line they need to cross to see improvement."

The study looked at patients with NASH, which is a type of liver disease characterized by excessive fat, causing inflammation and damage in the liver. Researchers set out to see if orlistat, which limits fat absorption, along with calorie restriction would lead to weight loss and improve liver disease in overweight patients with NASH, which was determined by a liver biopsy.

Fifty patients participated in the study, with all instructed to consume a 1,400 calorie diet and vitamin E, and half also receiving orlistat for 36 weeks, at which time liver biopsies were repeated.

While orlistat itself was not linked directly to improved liver health, weight loss was, and, further, researchers were able to pin-point the percentage of weight loss needed to improve liver damage.

Patients who lost 5 percent or more of body weight over nine months showed improvement in insulin resistance and steatosis (fat accumulation in the liver), and those who lost at least 9 percent showed reversal of their liver damage.

The data about the drug orlistat was less clear. Those in the orlistat group lost 8.3 percent body weight and those in the other group lost 6 percent body weight, not a statistically significant difference. As for liver disease, orlistat did not itself improve liver enzymes, measures of insulin resistance or reverse liver damage.

"The bottom line is that weight loss can help improve fatty liver disease," said Neuschwander-Tetri, who is a professor of internal medicine at Saint Louis University. "Now we know how much weight loss is needed for improvement, and we can give patients specific goals as they work to improve their health."


'/>"/>

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Related medicine news :

1. Early Weight Loss in Women Linked to Dementia
2. New research explores newborn in-hospital weight loss
3. Weight-Loss Surgeries Extend Lives
4. School-based overweight prevention program may cut risk of eating disorders among girls
5. Overweight toddlers and those not in day care at risk for iron deficiency
6. Weight Watchers Declares Quarterly Dividend
7. Eat Seafood, See Weight Loss: Recent Study Finds Another Reason to Eat Seafood for a Fit Lifestyle
8. Weight Gain May Spell Trouble for Heart Failure Patients
9. New Research From America On the Move Foundation Indicates American Weight Loss Efforts Stalling
10. Weight loss game looking for NEAT-o results
11. Aerobic, Weight Training Combo Best Against Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter President, Joette White, ... Pet Life Radio network. The episode, which was posted this week, features a ... factors led to Park Cities Pet Sitter’s being awarded the 2017 National Association of ...
(Date:2/17/2017)... NC (PRWEB) , ... February 17, 2017 , ... Smiles ... Commons Shopping Center in Davidson, NC. Dr. Brian Seese leads the practice as a ... dental services under one roof. Smiles by Seese serves patients of all ages with ...
(Date:2/17/2017)... ... February 17, 2017 , ... Wells Pharmacy Network offers ... of controlled and non-controlled substances plus the ability to manage orders on their ... States now accept electronic prescriptions, according to the Office of the National Coordinator ...
(Date:2/17/2017)... Palos Verdes, CA (PRWEB) , ... February 17, ... ... and emotional flow is Dr. Carol Francis' goals for each and ... Retreat Conference, Dr. Carol Francis will demonstrate five different brainwave tools which help ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... HIMSS17 Conference & Exhibition in Orlando, Fla., February 19-23. Visitors to the company’s ... most widely used electronic patient signatures solution in healthcare . , ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... -- On Thursday, February 16, 2017, the ... the closing bell, while the Dow Jones Industrial Average ... five out of nine sectors ended Thursday,s trading session ... Stock-Callers.com assessed the following Medical Appliances & Equipment equities ... SNN ), ABIOMED Inc. (NASDAQ: ABMD ), ...
(Date:2/16/2017)... EXTON, Pa. , Feb. 16, 2017 ... drugs, biologics, and medical devices, is pleased to announce ... Ph.D., has been selected as a winner of the ... SmartCEO Magazine and recognizes driven executives for ... undeniable work ethic. The awards ceremony and celebration is ...
(Date:2/16/2017)... , Feb. 16, 2017 Quest Diagnostics (NYSE: ... diagnostic information services, today announced that it has been ... 2017 by Fortune. The annual survey ... in the "Health Care: Pharmacy and Other Services" industry ... information services company to attain the designation. This is ...
Breaking Medicine Technology: