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Weight loss drug helps curb cocaine addictions, Penn study finds
Date:7/18/2013

PHILADELPHIAThe drug topiramate, typically used to treat epilepsy and more recently weight loss, may also help people addicted to both cocaine and alcohol use less cocaine, particularly heavy users, researchers in the department of Psychiatry at Penn Medicine report in a new study published in Drug and Alcohol Dependence. Results from the double-blind, placebo-controlled trial adds to the growing body of evidence supporting topiramate as a promising medication to treat addiction.

Past, separate studies have shown that topiramate can reduce alcohol dependence, as well as reduce relapse to cocaine; however, its use to treat both alcohol and cocaine dependent people has not been explored in a clinical trial. Cocaine and alcohol addictions often go hand in hand, so therapies targeting both may be the best strategy to treat individuals.

Results of the 13-week clinical trial of 170 alcohol and cocaine dependent people produced mixed results: The drug reduced alcohol cravings, but did not reduce drinking, and was not better at reducing cocaine cravings. Addicts on topiramate, however, versus those on a placebo were more likely to stay in treatment and abstain from cocaine during the last three weeks of the trial. People with more severe cocaine withdrawal symptoms agitation, restless behavior, and depressed moodappeared to have benefited most from topiramate.

"Cocaine dependence continues to be a significant public health concern in the United States and Europe. Drug counseling remains the treatment of choice, but many patients do not respond completely to it, so developing effective medications for treatment is a research priority," said first author Kyle M. Kampman, MD, professor of Psychiat
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Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

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