Navigation Links
Weight loss after gastric bypass surgery may protect against infection and cancer
Date:6/17/2008

Another health benefit of bariatric weight-loss surgery may be a heightened immune defense against cancer and infections, a new study suggests. The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

"Obesity is related to a higher rate of infections and some types of cancer," said a study coauthor, Alfredo Halpern, PhD, of the University of So Paulo, Brazil. "Nevertheless, there are only a few published studies evaluating the immune function in severely obese patients and the effect of surgery-induced weight loss on these parameters."

Halpern and his co-workers therefore studied the effect of weight loss on immune function in 28 morbidly obese patients who had traditional "stomach-stapling" (Roux-en-Y) gastric bypass surgery. The 20 women and eight men lost an average of 78.5 pounds 6 months after gastric bypass. This operation permanently reduces the size of the stomach and bypasses part of the intestines, thus restricting food intake and food absorption.

Before and 6 months after the surgery, the researchers evaluated patients' blood samples for natural killer (NK) cells, which play a critical role in controlling infections and cancer. Specifically, they measured the number of NK cells and the cells' capacity to kill infected cells or tumor cells. They also looked at the production of certain cytokines, proteins that are essential to the immune response.

Although the number of NK cells did not increase with surgically induced weight loss, their activity changed, Halpern said. Before surgery, NK cells mounted a weak immune defense, but after surgery their activity increased by nearly 79 percent, representing an improvement in the effective immune response and, possibly, in the ability to fight cancer and infections.

The response of cytokines involved in NK cell activity also changed after weight loss, possibly affording higher protection against infection and cancer, the researchers found. Cytokines analyzed were interferon-gamma and interleukins 2, 12 and 18.

Prior studies have shown that bariatric surgery has many health benefits, including resolution of type 2 diabetes, improved blood pressure and lower risk of premature death. This study shows another possible benefit of the weight loss stemming from bariatric surgery.

"It may help protect against infections and cancer by improving the activity of certain immune cells," Halpern said.

He said the impaired NK cell function evident in extremely obese people may even explain their propensity to develop infections and cancer.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Flavoring Food May Promote Weight Loss
2. Officeinacar Introduces Deskinacar - The Truly Portable Car Desk: the Lightweight Solution to a Businesspersons Travel Office Needs
3. Weight gain in children has no association with sugar-sweetened beverage consumption
4. Weight Watchers Declares Quarterly Dividend
5. REM sleep associated with overweight in children and adolescents
6. Video: Worlds Heaviest Man Celebrates Birthday and Weight Loss Milestone
7. Miami Institute Launches New Weight Loss Program
8. Women who gain excessive weight during pregnancy
9. Having heart surgery? Watch your blood sugar, especially if youre overweight or older
10. Weight Gain May Not Be Based Just on What You Eat
11. U of I study shows how to lose weight without losing bone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
Breaking Medicine Technology: