Navigation Links
Weight loss after gastric bypass surgery may protect against infection and cancer
Date:6/17/2008

Another health benefit of bariatric weight-loss surgery may be a heightened immune defense against cancer and infections, a new study suggests. The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

"Obesity is related to a higher rate of infections and some types of cancer," said a study coauthor, Alfredo Halpern, PhD, of the University of So Paulo, Brazil. "Nevertheless, there are only a few published studies evaluating the immune function in severely obese patients and the effect of surgery-induced weight loss on these parameters."

Halpern and his co-workers therefore studied the effect of weight loss on immune function in 28 morbidly obese patients who had traditional "stomach-stapling" (Roux-en-Y) gastric bypass surgery. The 20 women and eight men lost an average of 78.5 pounds 6 months after gastric bypass. This operation permanently reduces the size of the stomach and bypasses part of the intestines, thus restricting food intake and food absorption.

Before and 6 months after the surgery, the researchers evaluated patients' blood samples for natural killer (NK) cells, which play a critical role in controlling infections and cancer. Specifically, they measured the number of NK cells and the cells' capacity to kill infected cells or tumor cells. They also looked at the production of certain cytokines, proteins that are essential to the immune response.

Although the number of NK cells did not increase with surgically induced weight loss, their activity changed, Halpern said. Before surgery, NK cells mounted a weak immune defense, but after surgery their activity increased by nearly 79 percent, representing an improvement in the effective immune response and, possibly, in the ability to fight cancer and infections.

The response of cytokines involved in NK cell activity also changed after weight loss, possibly affording higher protection against infection and cancer, the researchers found. Cytokines analyzed were interferon-gamma and interleukins 2, 12 and 18.

Prior studies have shown that bariatric surgery has many health benefits, including resolution of type 2 diabetes, improved blood pressure and lower risk of premature death. This study shows another possible benefit of the weight loss stemming from bariatric surgery.

"It may help protect against infections and cancer by improving the activity of certain immune cells," Halpern said.

He said the impaired NK cell function evident in extremely obese people may even explain their propensity to develop infections and cancer.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Flavoring Food May Promote Weight Loss
2. Officeinacar Introduces Deskinacar - The Truly Portable Car Desk: the Lightweight Solution to a Businesspersons Travel Office Needs
3. Weight gain in children has no association with sugar-sweetened beverage consumption
4. Weight Watchers Declares Quarterly Dividend
5. REM sleep associated with overweight in children and adolescents
6. Video: Worlds Heaviest Man Celebrates Birthday and Weight Loss Milestone
7. Miami Institute Launches New Weight Loss Program
8. Women who gain excessive weight during pregnancy
9. Having heart surgery? Watch your blood sugar, especially if youre overweight or older
10. Weight Gain May Not Be Based Just on What You Eat
11. U of I study shows how to lose weight without losing bone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
Breaking Medicine Technology: