Navigation Links
Weight-based dosing of ribavirin improves outcomes for patients with hepatitis C
Date:10/1/2007

A sustained viral response was achieved by significantly more patients who received a weight-based dose (44.2 percent) than fixed dose (40.5 percent) ribavirin, the authors report. Overall, response rates decreased as weight increased when a fixed dose was used but remained unaltered with a weight-based dose. Discontinuation rates and reported adverse events did not differ significantly between the two treatment schemes, and relapse rates were lower for patients who had received weight-based dosing. The researchers also found that 48 weeks of treatment offered no additional benefit compared to 24 weeks for patients with genotypes 2 or 3..

Another group of researchers from the same study, also lead by Jacobson, used the study data to understand the impact of weight-based ribavirin with peginterferon alfa-2b in African American patients with HCV genotype 1. Genotype 1 is the hardest to treat, and it afflicts African Americans disproportionately.

Three hundred eighty seven African American patients with genotype 1 were included in the analysis: of those weighing 65 kg or more, and therefore receiving different doses of ribavirin in each arm, 188 had received flat-dose ribavirin, and 174 had received weight-based dosing. Significantly fewer patients in the flat-dose group (10 percent) attained a sustained virological response, compared to 21 percent in the flat-dose group. Relapse rates were 30 percent and 22 percent, respectively.

An unexpected finding of our study was the increase in efficacy with an increase in ribavirin dose in heavier patients, the authors report. That is, sustained viral response rates increased as body weight increased, suggesting that ribavirin distribution may be more complex than realized and body weight may only approximate the marker for size required to dose RBV consistently, the authors say.

In conclusion, weight-based dosing of ribavirin offered a significant advantage in efficacy of treatment fo
'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hypertension lowered by Bedtime Dosing
2. Researchers chides parents for overdosing their kids
3. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
4. Collagen improves voice quality in Parkinsonism
5. Breakfast improves memory
6. A new hearing device improves hearing
7. Hormone replacement therapy improves sexual function
8. New therapy improves quality of life for cancer
9. Adding contrast improves ultrasounds ability to detect prostate cancer
10. Switching drugs regularly improves HIV treatment
11. Sage Improves Memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... A recent survey found that the most ... skin health and beauty were: “Connections,” “climate,” “career” and ... and health advocate and radio host Sharon Kleyne agrees ... survey and the Four C’s.* Kleyne notes, however, that ... would benefit from paying attention to one’s daily fresh ...
(Date:12/15/2014)... Veretekk.com, Inc. announced today a strategic alliance ... Ocean Avenue has secured exclusive benefit to the strategic ... JM Ocean Avenue is a direct sales company ... and JM International, with partial ownership coming from JM ... , “After nearly 2 decades of servicing the industry ...
(Date:12/15/2014)... West Palm Beach, FL (PRWEB) December 15, 2014 ... Urgent Care , knows that holidays can be a daze ... accidents. From slips and falls while decking halls, to burns ... are plenty of holiday hazards that can happen at any ... reason for pain, MD Now has made a list of ...
(Date:12/15/2014)... Beltsville, MD (PRWEB) December 15, 2014 ... and services today released “ Social Media Cheat Sheets ... cultivating a community that drives results on the top ... a marketing program. It helps drive awareness, engagement, and ... conversions. For marketers to make an impact on new ...
(Date:12/15/2014)... HealthDay Reporter FRIDAY, Dec. ... reassure the millions of American women who have migraine: The ... "There is no association between migraine and breast cancer risk," ... at Harvard Medical School. "There is no positive association, so ... protective effect either." About 18 percent of American women ...
Breaking Medicine News(10 mins):Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 2Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 3Health News:JM Ocean Avenue secures the strategic advantages of Veretekk 4Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 2Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 3Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2
... Cancer progression is commonly thought of as a process involving ... which cancer cells leave the primary tumor and spread to ... Cancer Center shows that circulating tumor cells cancer cells ... other areas of the body can also return to ...
... , NEW YORK, Dec. 24 ... the Children,s Health Fund , a ... disadvantaged and medically underserved children, today released the following statement on ... Harry Reid: , "First and foremost, we applaud the Senate ...
... , WASHINGTON, Dec. 24 DNC Chairman Tim Kaine ... the Patient Protection and Affordable Care Act, landmark health care ... after overcoming a series of procedural hurdles and delay tactics ... ever reaching the Senate floor for a vote on final ...
... , WASHINGTON, Dec. 24 The following ... Medical Association: , "Today, the Senate took an historic ... coverage to millions of Americans and strengthening the private insurance ... The AMA supported passage of the bill because it ...
... House plan, before proposal can become law , THURSDAY, Dec. ... a Christmas Eve gift on Thursday with passage of a ... million uninsured Americans. , Obama said the Senate bill contains ... since his inauguration on Jan. 20. "Every single criteria for ...
... ... firms to have attained this highest level , ... (PRWEB) December 24, 2009 -- Partners Consulting’s Managed Services ... CMMI Level 5 Certification, the highest certification level of the Software Engineering Institute (SEI) ...
Cached Medicine News:Health News:'Self-seeding' of cancer cells may play a critical role in tumor progression 2Health News:Children & Health Reform: Where We Stand 2Health News:Children & Health Reform: Where We Stand 3Health News:DNC Chairman Tim Kaine Calls Senate Vote Historic, Says Landmark Health Reform Bill Is a Victory for the American People 2Health News:AMA: Senate Bill Passage Historic, More Work to Do in Conference 2Health News:Senate Passes Health Reform Package 2Health News:Senate Passes Health Reform Package 3Health News:Senate Passes Health Reform Package 4Health News:Partners Consulting's Managed Services Division Achieves CMMI Level 5 Certification 2
(Date:12/17/2014)... With advancements in neurological and functional ... seeing new growth, according to Kalorama Information. Though ... the majority of market volume, newer 3T systems ... are creating opportunities for more sophisticated applications. The medical ... a rate of 4%, with world market revenues ...
(Date:12/17/2014)... ANGELES , Dec. 17, 2014  ImmunoCellular ... the US Patent and Trademark Office (USPTO) has ... ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting six ... The claims of US Patent No. 8,871,211, which ... neural cancer by administering a dendritic cell composition ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, 2014 ... and Integrated Clinical Trial Services, LLC (ICTS), two ... clinical trials announce that they have formed a ... (i-CTMS). i-CTMS will provide a broad range of ... and medical device companies. i-CTMS will ...
Breaking Medicine Technology:Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3
... June 25 Perrigo Company (Nasdaq: PRGO ; TASE) announced ... present at the Oppenheimer 10th Annual Consumer, Gaming, Lodging & Leisure Conference ... at the Four Seasons Hotel in Boston .  The presentation will ... , , ...
... 25 PartsSource, the world,s #1 ebusiness solution ... has been honored with the 2010 Manny Award for ... its 13th year, the Manny Award program is committed ... companies for their innovations and best practices. This was the ...
Cached Medicine Technology:Perrigo Company to Present at the Oppenheimer 10th Annual Consumer, Gaming, Lodging and Leisure Conference 2PartsSource Wins 2010 Manny Award for Workplace Environment 2
... Design for Unparalleled Comfort Pick one of ... balance. Notice the trigger and ejector positionsright where ... our pipettors are ergonomically designed to help avoid ... pipetting. Productivity In The Palm Of Your ...
... best value in high performance electronic pipetting!, ... lightweight design reduce hand fatigue and strain ... tip ejector , Color coding for easy ... for greater performance use Hamilton AdvanTip Low ...
... The Finnpipette BioControl ... innovative features as the ... universal handle fits all ... single channel tip cone ...
... Entire Column of a 384 Well Plate at ... 384 well plates, you need a pipettor that ... exactly what you get with our 16-channel Impact ... Impact/Impact2), this innovation was specifically designed to allow ...
Medicine Products: