Navigation Links
Weight-based dosing of ribavirin improves outcomes for patients with hepatitis C
Date:10/1/2007

Patients with hepatitis C treated with combination therapy of pegylated interferon and ribavirin had better outcomes when taking a weight-based dosage of ribavirin compared to a flat dosage. This treatment technique also improved the response rates of African American patients, whose outcomes have lagged behind those of Caucasian patients. These findings are in the October issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The articles and an accompanying editorial are also available online at Wiley Interscience (http://www.interscience.wiley.com/journal/hepatology).

Combination therapy of pegylated interferon and ribavirin is the standard of care for patients with chronic hepatitis C, allowing more than half to achieve a sustained viral response. However, previous studies have suggested that a weight-based dose of ribavirin might lead to even better results. To examine this possibility, researchers, led by Ira Jacobson of Cornell University, conducted a large, multi-center, randomized, prospective, open-label study between December 2000 and June 2005.

They enrolled 5,027 patients with hepatitis C from more than 200 centers around the country. All participants were 18 to 70 years old, weighed less than 125 kg, had detectable HCV RNA in their blood, and had never been treated for it. They were randomly assigned to receive interferon and a flat dose of ribavirin (800 mg/day), or interferon and a weight-based dose of ribavirin, which started at 800 mg/day for patients weighing under 65 kg, and increased by 200 mg/day for up to each additional 20 kg of weight up to a maxiumum dose of 1400 mg. Those with HCV genotype 2 or 3, which is more responsive to interferon-based therapy, also tested treatment durations of 24 and 48 weeks. Each patient was followed up for 24 weeks after treatment.


'/>"/>
Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hypertension lowered by Bedtime Dosing
2. Researchers chides parents for overdosing their kids
3. Hypertensive Drug Improves Sexual Dysfunction in Hypertensive Men
4. Collagen improves voice quality in Parkinsonism
5. Breakfast improves memory
6. A new hearing device improves hearing
7. Hormone replacement therapy improves sexual function
8. New therapy improves quality of life for cancer
9. Adding contrast improves ultrasounds ability to detect prostate cancer
10. Switching drugs regularly improves HIV treatment
11. Sage Improves Memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (PRWEB) October 01, 2014 Between 23 ... in the U.S., according to figures from the National ... Diseases Association (AARDA), and many of them have something ... of having undiagnosed celiac disease. Gluten Free Therapeutics, ... awareness of undiagnosed celiac disease by publishing a series ...
(Date:10/1/2014)... Diet Doc understands that many of their clients have ... dieting attempts could be easily sabotaged by the temptation to ... into their programs as a way to control the ... weight loss results, it also allows patients to stick with ... weight for the future. , Earlier versions of the hormone ...
(Date:10/1/2014)... 01, 2014 Anti Aging Clinic (AntiAgingClinic.ca), ... rejuvenating destination of choice, is announcing a discounted cost ... to December. , “We’re doing this because we want ... our top skin clinic in Toronto,” says Dr. Brian ... much at Anti Aging Clinic, including laser facials, genesis ...
(Date:10/1/2014)... 2014 On Sept. 9, Chapín Coffee ... the Martha Stewart American Made Awards (MSAMAs), an annual ... country in the fields of crafts, design, food and ... a finalist in the MSAMAs, which celebrates entrepreneurs and ... improving local communities and changing the way we shop, ...
(Date:10/1/2014)... Nordic Naturals is kicking off ... cause. The campaign—“Buy One Bottle. Help Two Heroes.”—will ... a nonprofit organization that helps rebuild the lives ... that would otherwise face euthanasia. From October through ... monthly donations of Nordic Naturals omega-3s to veterans ...
Breaking Medicine News(10 mins):Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2
... Analysis finds side effects, loss of effectiveness over time , , ... widely used to treat restless legs syndrome do provide relief, ... loss of effectiveness that causes many sufferers to stop taking ... that we found that we can,t fully explain is that ...
... other influences are limiting the growth ... of frequency and severity of claims, ... leading provider of global risk management and consulting services,today released ... for the first time in nine years of reporting that ...
... a request for proposals, to expand oral health care services; awards ... ... HINSDALE, Ill., May 12 As part of the Illinois,Children,s Healthcare Foundation,s ... Illinois children, the,Foundation is pleased to announce a request for proposals in ...
... cancer exceeds 2/3rds enrolment level - ... peritoneal cancers -, BELLEVILLE, ON, May 12 ... research-based, technology-driven Canadian,biopharmaceutical company, is pleased to provide ... its proprietary platform technology:,Mycobacterial Cell Wall-DNA Complex (MCC)., ...
... blockage more than doubles when these conditions go untreated , , ... high cholesterol levels not only are bad for your heart, ... , The two conditions appear to increase one,s risk for ... It results from one or more veins carrying blood from ...
... use of naproxen might even harm cognitive function , , MONDAY, ... new trial shows that daily use of two popular pain-relieving ... people with a family history of Alzheimer,s disease. , In ... Naprosyn, may even have a deleterious effect on cognitive function, ...
Cached Medicine News:Health News:Drugs for Restless Legs Syndrome Have Downsides 2Health News:Drugs for Restless Legs Syndrome Have Downsides 3Health News:Aon Study Finds Stability in Nationwide Liability Costs in the Long Term Health Care Sector 2Health News:Aon Study Finds Stability in Nationwide Liability Costs in the Long Term Health Care Sector 3Health News:Children in Illinois to Have Healthier Smiles 2Health News:Bioniche Updates re: Mycobacterial Cell Wall Technology Platform 2Health News:Bioniche Updates re: Mycobacterial Cell Wall Technology Platform 3Health News:Bioniche Updates re: Mycobacterial Cell Wall Technology Platform 4Health News:High Blood Pressure, Cholesterol Associated With Eye Disease 2Health News:Celebrex, Naproxen Won't Prevent Mental Decline 2Health News:Celebrex, Naproxen Won't Prevent Mental Decline 3
(Date:10/1/2014)... , Oct. 1, 2014 Trovagene, Inc., ... announced today that Eli Diamond , MD, ... Center (MSK), presented clinical data from an ongoing ... monitoring platform for the determination of oncogene mutational ... biopsy.  The results were presented to both treating ...
(Date:10/1/2014)... MARCOS, Texas , Oct. 1, 2014 /PRNewswire/ ... it is scaling volume production of photoactive quantum ... power technologies . While offering numerous advantages for ... of producing large quantities of quantum dots with ... until now kept them from commercial utilization and ...
(Date:10/1/2014)... Oct. 1, 2014  CVS Health is thanking its ... role in changing the way health care is delivered ... the Company,s retail pharmacies, mail service pharmacies and specialty ... our company name to CVS Health to reflect our ... the innovations needed to shape the future of health," ...
Breaking Medicine Technology:Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 4Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 3CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 2CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 3
... 2012 i-Path Media LLC, a pharmaceutical marketing ... with their clients, received national certification as a ... Organization-New York Certification Committee, a regional certifying partner ... WBENC,s national standard of certification is ...
... Jan. 16, 2012  Palatin Technologies, Inc. (NYSE Amex: ... targeted, receptor-specific peptide therapeutics for the treatment of ... potential, today announced that Dr. Carl Spana, President ... Noble Financial Capital Markets, Eighth Annual Equity Conference.  ...
Cached Medicine Technology:Palatin Technologies to Present at BOCEMb, Noble Financial Capital Markets' Eighth Annual Equity Conference 2
... testing your blood glucose regularly, you want ... possible. Conventional spring-loaded lancet systems often penetrate ... cause painful dilation or tearing of skin ... a precise, linear action that provides greater ...
... Focus from Thermo Labsystems was designed specifically ... Advanced features such as the new fast ... on microvolumes help to define this as ... The new interchangeable handle plate offers a ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,410-0) or contact custom...
... models cover the range from 2ul to 5000ul. ... Volume lock design prevents inadvertent volume change. ... Whole pipette is autoclavable at 121C(250F). ... polypropylene. Suitable for one-handed operation. Auto ...
Medicine Products: