Navigation Links
Weight Loss Might Ease Psoriasis, Study Hints

By Dennis Thompson
HealthDay Reporter

WEDNESDAY, May 29 (HealthDay News) -- People with psoriasis who lose weight could experience some relief from the symptoms of their chronic skin disease, according to a small new study.

A clinical trial based in Denmark found that obese patients with psoriasis who lost weight through a low-calorie diet experienced a significant improvement in their quality of life, compared to obese psoriasis patients who didn't lose weight.

The patients in the weight-loss group reported less stinging and burning, were less likely to be embarrassed by unsightly lesions, and found that their condition affected their everyday life less often, said Dr. Peter Jensen, of the Copenhagen University Hospital Gentofte, and colleagues.

"Our results emphasize the importance of weight loss as part of a multimodal treatment approach to effectively treat both the skin condition and its [related medical] conditions in overweight patients with psoriasis," the researchers said in the study, which was published online May 29 in the journal JAMA Dermatology.

Psoriasis is a chronic inflammatory skin disease that develops when a person's immune system malfunctions and causes skin cells to grow too quickly. The new skin cells form in days rather than weeks and pile up on the skin's surface, causing scaly, painful lesions.

In the randomized clinical trial, 27 patients were assigned to an intervention group that followed a low-calorie diet and 26 patients were assigned to a control group that continued to eat ordinary healthy foods. Researchers tracked psoriasis symptoms and quality of life using two questionnaires.

The patients on a low-calorie diet ended up losing nearly 34 pounds in 16 weeks, and reported improvements in both their psoriasis symptoms and their overall quality of life.

Dermatologists said the study's results are not surprising, but do reinforce the need for overweight or obese people with psoriasis to try to lose weight.

"Obesity is a huge issue for patients with psoriasis," said Dr. Joel Gelfand, an associate professor of dermatology and medical director of the clinical studies unit at the Hospital of the University of Pennsylvania, in Philadelphia. "If you're obese with psoriasis, psoriasis is less likely to get clear."

There are a couple reasons excess weight can exacerbate a person's psoriasis. First, psoriasis is an inflammatory disease, and obesity is a known cause of inflammation, said Dr. Larry Green, chairman of the research committee for the National Psoriasis Foundation.

"Anytime someone is obese, it's going to affect how their body can heal because it's a stress on the body and stress affects inflammation," Green said. "By losing weight, they're going to reduce the burden on their body."

Another possibility is that obesity may cause immune system responses that are very similar to those prompted by psoriasis.

"Obesity is associated with the same elevations of cytokines in the blood that promote psoriasis," Gelfand said. Cytokines are small signaling proteins used to regulate the body's immune response.

On a more mundane level, obesity also causes skin friction as parts of the body rub against each other, another expert said.

"If skin rubs against skin, psoriasis gets worse," said Dr. Jeffrey Weinberg, a dermatologist at Beth Israel Medical Center in New York City. "Friction makes psoriasis get worse."

Gelfand said it's difficult to draw major clinical conclusions from such a small pilot study, adding that the people in the Danish study suffered from mild to moderate psoriasis and therefore were less likely to experience a vast improvement in their symptoms from weight loss.

"Larger studies in a population of patients with more severe skin disease are necessary to determine if these findings are clinically important," he said.

More information

The American Academy of Dermatology has more about psoriasis.

SOURCES: Joel Gelfand, M.D., associate professor of dermatology, and medical director, clinical studies Hospital of the University of Pennsylvania, Philadelphia; Larry Green, M.D., chairman, research committee, National Psoriasis Foundation; Jeffrey Weinberg, M.D, dermatologist, Beth Israel Medical Center, New York City; May 29, 2013, JAMA Dermatology, online

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tree nut consumption associated with lower body weight and lower prevalence of health risks
2. Even Preschoolers View the Overweight Negatively
3. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
4. Overweight Pregnant Women at Higher Risk for Complications
5. Can weight loss help African-American breast cancer survivors?
6. Guidelines say diet, exercise, weight control improve odds after cancer diagnosis
7. Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies
8. Healthy Weight Loss May Also Cut Your Cancer Risk
9. In Moms Eyes, Overweight Toddler May Not Be
10. IUD Use Tied to Modest Weight Loss
11. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
Post Your Comments:
Related Image:
Weight Loss Might Ease Psoriasis, Study Hints
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today that ... Supplier Horizon Award . One of ... was recognized for its support of Premier members through ... clinical excellence, and commitment to lower costs. ... this recognition of our outstanding customer service from Premier," ...
Breaking Medicine Technology: