Navigation Links
Wayne State to explore adult onset diseases and possible origins during early development
Date:5/2/2014

DETROIT A team of researchers at Wayne State University, the University of Alabama at Birmingham and the University of Pittsburgh was recently awarded nearly $2 million from the National Institute of Environmental Health Sciences of the National Institutes of Health to explore possible determinants of susceptibility to common diseases such as diabetes, atherosclerotic heart disease, and various cancers. All of these diseases are considered to be adult-onset pathologies, but the research team is exploring the possibility of origins during early periods of human development.

Melissa Runge-Morris, M.D., director of the Institute of Environmental Health Sciences (IEHS) and professor of oncology at Wayne State, was awarded the 5-year grant "Expression, Regulation and Function of the SULT1C Carcinogen-Activating Enzymes." Thomas A. Kocarek, Ph.D., also of IEHS and associate professor of pharmacology is co-investigator on the project.

"Our long-term goal is to understand how sulfotransferase enzymes might impact drug efficacy and safety, as well as susceptibility to environmental carcinogens and modulators of metabolic processes," said Runge-Morris.

Because sulfotransferase 1C (SULT1C) enzymes are mainly expressed early in life, they likely play important physiological roles during development. However, since the SULT1C enzymes can also convert environmental chemicals into toxic molecules, early SULT1C expression might lead to disease development later in life.

"This research will help us obtain critical information on SULT1C gene expression, regulation, and function, and how these enzymes likely play important physiological roles during development," said Runge-Morris. "Due to their distinct abilities to bioactivate toxic and carcinogenic compounds, they are primed to promote disease susceptibility during critical windows of vulnerability, and we hope this research will shed new light on the origins of common diseases and offer new hope for reducing their onset in the future."

The project number for this National Institutes of Health R01 grant is ES022606.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Wayne State University researcher examines proteins role in diabetic retinopathy
2. Wayne State University researcher seeks to understand link between obesity, flu severity
3. Algae extract increases good cholesterol levels, Wayne State research finds
4. Wayne State develops better understanding of memory retrieval between children and adults
5. Wayne State research team finds possible clue to progression of MS
6. Wayne State researchers say adolescent smoking prevention programs still critical
7. Wayne State University researcher recognized by American Psychological Association
8. CDC funds Wayne State University research to understand, prevent teen dating violence
9. Wayne State researcher finds possible clue to childrens early antisocial behavior
10. Wayne State University researcher to evaluate success of text message diabetes intervention
11. Wayne State embarks on study to improve identification of women at high risk of stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th ... Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, ... The fun run is geared towards children of all ages; it is a non-competitive, ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
Breaking Medicine Technology: