Navigation Links
Wayne State to explore adult onset diseases and possible origins during early development
Date:5/2/2014

DETROIT A team of researchers at Wayne State University, the University of Alabama at Birmingham and the University of Pittsburgh was recently awarded nearly $2 million from the National Institute of Environmental Health Sciences of the National Institutes of Health to explore possible determinants of susceptibility to common diseases such as diabetes, atherosclerotic heart disease, and various cancers. All of these diseases are considered to be adult-onset pathologies, but the research team is exploring the possibility of origins during early periods of human development.

Melissa Runge-Morris, M.D., director of the Institute of Environmental Health Sciences (IEHS) and professor of oncology at Wayne State, was awarded the 5-year grant "Expression, Regulation and Function of the SULT1C Carcinogen-Activating Enzymes." Thomas A. Kocarek, Ph.D., also of IEHS and associate professor of pharmacology is co-investigator on the project.

"Our long-term goal is to understand how sulfotransferase enzymes might impact drug efficacy and safety, as well as susceptibility to environmental carcinogens and modulators of metabolic processes," said Runge-Morris.

Because sulfotransferase 1C (SULT1C) enzymes are mainly expressed early in life, they likely play important physiological roles during development. However, since the SULT1C enzymes can also convert environmental chemicals into toxic molecules, early SULT1C expression might lead to disease development later in life.

"This research will help us obtain critical information on SULT1C gene expression, regulation, and function, and how these enzymes likely play important physiological roles during development," said Runge-Morris. "Due to their distinct abilities to bioactivate toxic and carcinogenic compounds, they are primed to promote disease susceptibility during critical windows of vulnerability, and we hope this research will shed new light on the origins of common diseases and offer new hope for reducing their onset in the future."

The project number for this National Institutes of Health R01 grant is ES022606.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Wayne State University researcher examines proteins role in diabetic retinopathy
2. Wayne State University researcher seeks to understand link between obesity, flu severity
3. Algae extract increases good cholesterol levels, Wayne State research finds
4. Wayne State develops better understanding of memory retrieval between children and adults
5. Wayne State research team finds possible clue to progression of MS
6. Wayne State researchers say adolescent smoking prevention programs still critical
7. Wayne State University researcher recognized by American Psychological Association
8. CDC funds Wayne State University research to understand, prevent teen dating violence
9. Wayne State researcher finds possible clue to childrens early antisocial behavior
10. Wayne State University researcher to evaluate success of text message diabetes intervention
11. Wayne State embarks on study to improve identification of women at high risk of stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... Cheryl Bowker of Bowker Insurance Group ... Dick McKenna Good Hands Legacy Award. McKenna ran one of Allstate’s most successful agencies ... inspire all those who knew him. The award named for him is not given ...
(Date:5/25/2016)... Puerto Vallarta, Mexico (PRWEB) , ... May 25, 2016 , ... ... menu surrounding the restorative properties of precious stones to complement its new wellness ... spread over two floors and feature a plethora of special services and insuite amenities, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Laser Skin & Wellness ... back the hands of time of female aging. The Juliet™ procedure ... with symptoms such as leakage, laxity, itchiness and pain have reported real relief from ...
(Date:5/25/2016)... ... May 25, 2016 , ... First Choice Emergency ... named Dr. Anh Tat Nguyen, as the Medical Director of its new DeSoto facility. ... Director of our new DeSoto location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:5/24/2016)... ... May 24, 2016 , ... Sterling Global Products is launching a Kickstarter ... refillable hanging wipe dispenser. The campaign kick-off video is located via this link ... 2016. The goal is to raise $1,000 per day for a total of $25,000. ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
(Date:5/25/2016)... , May 25, 2016 ... H1 2016"market research report that provides an overview ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
(Date:5/24/2016)...  Diana Russell suffers from a form of rheumatoid ... out.  This disease has put her in a wheelchair, ... grandchildren to leave her home.  Because of the size ... the wheelchair.  So if there is a family function, ... left to wait for the bus. Photo ...
Breaking Medicine Technology: