Navigation Links
Wayne State researchers find new way to examine major depressive disorder in children
Date:5/10/2011

DETROIT A landmark study by scientists at Wayne State University published in the May 6, 2011, issue of Archives of General Psychiatry, the most prestigious journal in the field, has revealed a new way to distinguish children with major depressive disorder (MDD) from not only normal children, but also from children with obsessive compulsive disorder (OCD).

MDD is a common, debilitating disease prevalent in childhood and adolescence. Examination of cortical thickness in patients with MDD has not been widely studied, and WSU's team of researchers set out to determine if differences in cortical thickness might not only distinguish children with depression from healthy children who are not depressed but also from those with other psychiatric disorders such as OCD.

Using a new technique to measure cortical thickness of 24 MDD patients, 24 OCD patients and 30 healthy control patients, the research team led by David Rosenberg, M.D., the Miriam L. Hamburger Endowed Chair of Child Psychiatry and professor of psychiatry and behavioral neurosciences in the School of Medicine at Wayne State University, and Erin Fallucca, M.D., a psychiatry resident at Wayne State University and the Detroit Medical Center, observed cortical thinning in five regions of the brain and greater thickness in the bilateral temporal pole in MDD patients. In OCD patients, the only significantly different region from healthy control patients was a thinner left supramarginal gyrus.

"The findings from our study are very exciting," said Rosenberg. "By measuring cortical thickness, we were able to distinguish depressed children not only from healthy children without depression, but also from those with another psychiatric disorder, obsessive compulsive disorder."

The study also revealed that familial depressed patients, or children with at least one first-degree relative with depression, had distinct cortical thickness compared to children with no obvious family history of mood disorder.

"Depressed children with and without a family history of depression who met the same clinical criteria of depression and who appeared the same clinically, had completely different cortical thickness based on their family history of depression," said Rosenberg.

This study offers an exciting new way to identify more objective markers of psychiatric illness in children. "It may have potential treatment significance for one-third of depressed children who do not respond to any treatment, and also for many who only partially respond with continued functional impairment," said Rosenberg. "We have found a clue to guide us to look at subtypes of depression just as we would in other chronic medical illnesses like diabetes, such as insulin dependent and non-insulin dependent diabetes."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@gmail.com
734-748-4207
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Wayne State leads study to improve management of cancer pain in African Americans
2. Wayne State study links testosterone with mens ability to woo potential mates
3. Wayne State University researchers publish results settling multiple sclerosis debate
4. Speaking the same language means better health care quality, Wayne State University study finds
5. Wayne State University study predicts risk of memory loss in healthy, older adults
6. Community Health Systems, Inc.s Wayne T. Smith and Larry Cash Named Americas Top Healthcare CEO and CFO
7. New marker offers hope for more reliable detection of prostate cancer
8. Sensitizing prostate cancer to radiotherapy
9. Surgery reduces risk of mortality due to prostate cancer even for low-risk groups
10. Penn State to help brush up oral hygiene in nursing homes
11. Aggressive Treatment May Be Beneficial for Early Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Hatboro, Pennsylvania (PRWEB) , ... March 24, 2017 ... ... and recycling solutions for contaminated soil, dredged material, and hazardous and non-hazardous materials ... headquartered in Allentown, Pennsylvania. This acquisition will add four additional processing facilities ...
(Date:3/24/2017)... ... ... Digital Scientists, a software innovation lab specializing in web design and ... Carolina location. The lab has set up shop at the renowned NEXT Innovation ... Carolina clients for years from our office here in Atlanta,” explains Digital Scientists’ CEO, ...
(Date:3/24/2017)... ... , ... The iaedp Foundation, the premier provider of educational programs and training ... the full spectrum of disordered eating, announced today that the 2017 Symposium set a ... states and several countries converged on the Green Valley Resort in Las Vegas. ...
(Date:3/24/2017)... ... March 24, 2017 , ... As the standards bearer ... communications platform that positions them as the go-to thought leader in all matters ... publication as an always-on, always-fresh news, views and advocacy engine, called ONS Voice. ...
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy gaining ... issues tend to appreciate and love the "Informed" series, hosted by Rob Lowe. ... causes around the world. , Running for charity has become a multi-million ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 ... research report created through extensive primary research (inputs ... the report aims to present the analysis of ... of Procedure (Replacement and Repair); Replacement Procedure By ... Repair By Technique (Surgical Devices, Balloon Valvuloplasty, Transcatheter ...
(Date:3/23/2017)... , March 23, 2017 As a ... along with the prevalence of allergic diseases, cutting ... are currently revolutionising the ways in which pharmaceutical ... Allergies 2017 promises to be both a high ... the allergy interest groups, immunologists, research scholars and ...
(Date:3/23/2017)... -- Summary Global Markets ... Primary Hyperoxaluria - Pipeline Review, H1 2017, provides ... System And Sex Hormones) pipeline landscape. Primary ... kidney and bladder stones. It results from the ... blood in the urine, pain when urinating, fever, ...
Breaking Medicine Technology: