Navigation Links
Wayne State researchers find new way to examine major depressive disorder in children
Date:5/10/2011

DETROIT A landmark study by scientists at Wayne State University published in the May 6, 2011, issue of Archives of General Psychiatry, the most prestigious journal in the field, has revealed a new way to distinguish children with major depressive disorder (MDD) from not only normal children, but also from children with obsessive compulsive disorder (OCD).

MDD is a common, debilitating disease prevalent in childhood and adolescence. Examination of cortical thickness in patients with MDD has not been widely studied, and WSU's team of researchers set out to determine if differences in cortical thickness might not only distinguish children with depression from healthy children who are not depressed but also from those with other psychiatric disorders such as OCD.

Using a new technique to measure cortical thickness of 24 MDD patients, 24 OCD patients and 30 healthy control patients, the research team led by David Rosenberg, M.D., the Miriam L. Hamburger Endowed Chair of Child Psychiatry and professor of psychiatry and behavioral neurosciences in the School of Medicine at Wayne State University, and Erin Fallucca, M.D., a psychiatry resident at Wayne State University and the Detroit Medical Center, observed cortical thinning in five regions of the brain and greater thickness in the bilateral temporal pole in MDD patients. In OCD patients, the only significantly different region from healthy control patients was a thinner left supramarginal gyrus.

"The findings from our study are very exciting," said Rosenberg. "By measuring cortical thickness, we were able to distinguish depressed children not only from healthy children without depression, but also from those with another psychiatric disorder, obsessive compulsive disorder."

The study also revealed that familial depressed patients, or children with at least one first-degree relative with depression, had distinct cortical thickness compared to children with no obvious family history of mood disorder.

"Depressed children with and without a family history of depression who met the same clinical criteria of depression and who appeared the same clinically, had completely different cortical thickness based on their family history of depression," said Rosenberg.

This study offers an exciting new way to identify more objective markers of psychiatric illness in children. "It may have potential treatment significance for one-third of depressed children who do not respond to any treatment, and also for many who only partially respond with continued functional impairment," said Rosenberg. "We have found a clue to guide us to look at subtypes of depression just as we would in other chronic medical illnesses like diabetes, such as insulin dependent and non-insulin dependent diabetes."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@gmail.com
734-748-4207
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Wayne State leads study to improve management of cancer pain in African Americans
2. Wayne State study links testosterone with mens ability to woo potential mates
3. Wayne State University researchers publish results settling multiple sclerosis debate
4. Speaking the same language means better health care quality, Wayne State University study finds
5. Wayne State University study predicts risk of memory loss in healthy, older adults
6. Community Health Systems, Inc.s Wayne T. Smith and Larry Cash Named Americas Top Healthcare CEO and CFO
7. New marker offers hope for more reliable detection of prostate cancer
8. Sensitizing prostate cancer to radiotherapy
9. Surgery reduces risk of mortality due to prostate cancer even for low-risk groups
10. Penn State to help brush up oral hygiene in nursing homes
11. Aggressive Treatment May Be Beneficial for Early Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... Board-certified oculoplastic ... Journal , the official journal of The American Society for Aesthetic Plastic Surgery, ... The procedure is designed to correct drooping, retracted lower eyelids, which usually result ...
(Date:1/16/2017)... UT (PRWEB) , ... January 16, 2017 , ... One ... not only to treat, but to test for, as well. The money spent screening ... every year.(1) Doctors in the U.S. screen patients for cancer more than in any ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... Executive Officer of the medical device company, effective immediately. , “This is perfect ... “Kevin has a strong track record in medical device market development and revenue ...
(Date:1/15/2017)... ... , ... In this role, Courtney will be responsible for developing new business ... friendly mark. This certification program was created by ASL and the nonprofit Asthma and ... suitable for the 60+ million people living in the U.S. with asthma and allergies. ...
(Date:1/15/2017)... ... ... is announcing the release of an updated version of their top selling clipper, the ... wide jaws that will accommodate nails up to 4mm in thickness . Nails like ... reinforced for extra strength when pressing down on dense nails which can be a hindrance ...
Breaking Medicine News(10 mins):
(Date:1/14/2017)... , Jan. 14, 2017  Johnson & Weaver, LLP announces ... purchasers of Zimmer Biomet Holdings, Inc. (NYSE: ZBH ... October 31, 2016 (the "Class Period"). Zimmer Biomet ... markets orthopaedic reconstructive products, such as knee and hip reconstructive ... ...
(Date:1/13/2017)... , January 13, 2017 ... "Transfection Reagents and Equipment Market by Method (Biochemical ... Application (Biomedical, Protein Production), End User - Global ... studies the global market from 2016 to 2021. ... Billion by 2021 from USD 715.4 Million in ...
(Date:1/13/2017)... , January 13, 2017 The 2016 ... industry, with several states voting in favor of legalizing cannabis ... largest Cannabis market in the U.S. In addition, the state ... mark in annual cannabis products sales. The ArcView Group has ... which the legal cannabis sales in the U.S. last year ...
Breaking Medicine Technology: