Navigation Links
Wayne State receives DOD grant; study may give insight to slow or halt breast cancer
Date:12/23/2011

DETROIT A Wayne State University School of Medicine post-doctoral researcher has secured a significant grant to study the signaling process that triggers a type of breast cancer to transform into an invasive state.

Kingsley Osuala, Ph.D., a post-doctoral trainee in the Department of Pharmacology, has secured a three-year, $450,000 grant from the Department of Defense Breast Cancer Research Program for his study, "Paracrine Cytokine/Chemokine Pathways in Progression of Ductal Carcinoma in Situ to Invasive Ductal Carcinoma."

"This is especially exciting as only 22 grants nationally were issued in this category for this fiscal year," said Osuala, who received his doctorate in biomedical science from the University of Central Florida. "This is a major milestone for me because it will be the first grant on which I am listed as principal investigator."

Osuala is investigating the process by which breast cancer moves from a pre-invasive state to an invasive state. Ductal carcinoma in situ (DCIS), a pre-invasive breast cancer, was the fourth-leading cause of cancer diagnosed in women worldwide in 2010. Communication between the DCIS cells and other surrounding cells is known to accelerate movement to an invasive cancer, but the molecules responsible for the process have not been identified, he said.

The objective of the study, Osuala said, is to evaluate the potential roles of two small proteins that communicate between cells the chemokine CCL20 and the cytokine IL-6 in the progression of DCIS to an invasive state. Recent data has uncovered a previously unknown mechanism by which cancer cells increase expression of CCL20 and IL-6 to manipulate their environment, rendering them invasive. Thus, CCL20 and IL-6 may be potential targets for new drugs as well as markers that might allow doctors to accurately predict which patients with DCIS are likely to have it progress to invasive tumors, he said.

"By identifying chemokine/cytokine signaling pathways that are critical to breast cancer progression, we should be able to slow or even halt the invasion of breast cancers," he said. "Such an advantage would give clinicians more time to treat and remove breast cancer before it can travel to other organs. This study is unique in that we are evaluating the tumor and other cells in the tumor's microenvironment rather than just the tumor cells alone. This novel approach will provide answers about the way tumors interact with their neighboring cells."

The study, Osuala said, will provide technical insight for future studies in the discovery of biomarkers for early-stage breast cancers and in breast cancer in general.

"Defining new drug targets should give clinicians a new tool for the treatment of breast cancer, potentially increasing the post-diagnosis life expectancy of patients," he said. "Additional benefits of this study include decreased reliance on toxic therapies such as radiotherapy and conventional chemotherapy, and reductions in overtreatment."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Community Health Systems, Inc.s Wayne T. Smith and Larry Cash Named Americas Top Healthcare CEO and CFO
2. Wayne State University study predicts risk of memory loss in healthy, older adults
3. Speaking the same language means better health care quality, Wayne State University study finds
4. Wayne State University researchers publish results settling multiple sclerosis debate
5. Wayne State study links testosterone with mens ability to woo potential mates
6. Wayne State leads study to improve management of cancer pain in African Americans
7. Wayne State researchers find new way to examine major depressive disorder in children
8. Wayne State University researchers win grant from the NSF to target tinnitus
9. Religion benefits traumatic brain injury victims, Wayne State University research finds
10. Health providers should emphasize breast cancer screening, Wayne State University research finds
11. Wayne State University researcher argues that sex reduces genetic variation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... 20, 2017 , ... AMC Health , the leading provider of proven ... trials market. Similar to its approach in demonstrating positive outcomes in the healthcare market, ... proving the value of eVisits to support virtual studies. , In a ...
(Date:6/20/2017)... ... June 20, 2017 , ... With certifications and experience that puts ... NJ, Drs. Adam and Hal Kimowitz are currently accepting new patients at their practice ... can cause for some patients, which is why they offer the latest in modern ...
(Date:6/20/2017)... ... June 20, 2017 , ... Uniform Advantage (UA), a multi-channel retailer ... designed to create tailored looks and athleisure-inspired outfits. UA Flex fabric is breathable, wrinkle ... twill. , With trendy looks hitting the medical community, UA Flex is for the ...
(Date:6/20/2017)... ... 20, 2017 , ... MEDI+SIGN, a healthcare technology company that ... Stanowski, DHA, FACHE to the MEDI+SIGN Advisory Board. , “We are eager ... provide invaluable direction for the company,” says Andrew Hoffman, President of MEDI+SIGN. ...
(Date:6/19/2017)... ... June 19, 2017 , ... The joyful summer wedding ... to be a humdinger. A warm winter and wet spring have created ideal conditions ... one wants to be swatting away pesky mosquitoes when a bride and groom are ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... June 8, 2017   Responding to Heath Ledger,s ... the death of singer Chris Cornell in May, ... International offers a free online psychiatric drug ... and families about psychotropic drug risks. The ... died from an accidental overdose, has called for tighter rules ...
(Date:6/7/2017)... Md. , June 7, 2017  Novavax, Inc., (Nasdaq: ... second of two Phase 2 trials of its RSV F ... of child bearing age have been published in the journal ... publication have been shared in prior scientific conferences). The Company ... in April 2014. Novavax is developing the RSV F Vaccine ...
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy & Homecare is ... the United States . The Raizer is a ... fallen person up to an almost-standing position within ... operated by one assistant and does not require ... enough that a child can operate it, and ...
Breaking Medicine Technology: