Navigation Links
Wayne State receives DOD grant; study may give insight to slow or halt breast cancer
Date:12/23/2011

DETROIT A Wayne State University School of Medicine post-doctoral researcher has secured a significant grant to study the signaling process that triggers a type of breast cancer to transform into an invasive state.

Kingsley Osuala, Ph.D., a post-doctoral trainee in the Department of Pharmacology, has secured a three-year, $450,000 grant from the Department of Defense Breast Cancer Research Program for his study, "Paracrine Cytokine/Chemokine Pathways in Progression of Ductal Carcinoma in Situ to Invasive Ductal Carcinoma."

"This is especially exciting as only 22 grants nationally were issued in this category for this fiscal year," said Osuala, who received his doctorate in biomedical science from the University of Central Florida. "This is a major milestone for me because it will be the first grant on which I am listed as principal investigator."

Osuala is investigating the process by which breast cancer moves from a pre-invasive state to an invasive state. Ductal carcinoma in situ (DCIS), a pre-invasive breast cancer, was the fourth-leading cause of cancer diagnosed in women worldwide in 2010. Communication between the DCIS cells and other surrounding cells is known to accelerate movement to an invasive cancer, but the molecules responsible for the process have not been identified, he said.

The objective of the study, Osuala said, is to evaluate the potential roles of two small proteins that communicate between cells the chemokine CCL20 and the cytokine IL-6 in the progression of DCIS to an invasive state. Recent data has uncovered a previously unknown mechanism by which cancer cells increase expression of CCL20 and IL-6 to manipulate their environment, rendering them invasive. Thus, CCL20 and IL-6 may be potential targets for new drugs as well as markers that might allow doctors to accurately predict which patients with DCIS are likely to have it progress to invasive tumors, he said.

"By identifying chemokine/cy
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Community Health Systems, Inc.s Wayne T. Smith and Larry Cash Named Americas Top Healthcare CEO and CFO
2. Wayne State University study predicts risk of memory loss in healthy, older adults
3. Speaking the same language means better health care quality, Wayne State University study finds
4. Wayne State University researchers publish results settling multiple sclerosis debate
5. Wayne State study links testosterone with mens ability to woo potential mates
6. Wayne State leads study to improve management of cancer pain in African Americans
7. Wayne State researchers find new way to examine major depressive disorder in children
8. Wayne State University researchers win grant from the NSF to target tinnitus
9. Religion benefits traumatic brain injury victims, Wayne State University research finds
10. Health providers should emphasize breast cancer screening, Wayne State University research finds
11. Wayne State University researcher argues that sex reduces genetic variation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Following yesterday’s announcement that Ascenta Health ... health brand Nature’s Way, Marc St-Onge has affirmed his ... Skin is an integral part of the agreement with ... to further develop Ascenta Skin into a leading player ... a breakthrough, anti-aging skincare supplement featuring 6 active ingredients ...
(Date:5/22/2015)... 2015 Omar Ahmad Barrada, a junior ... in the 2015 Congress of Future Medical Leaders in ... gathering of “America’s highest achieving high school students.” , ... set new goals and learn better study habits,” said ... during which we can ask the surgeons questions.” , ...
(Date:5/22/2015)... May 22, 2015 Combination therapy, ... option for chronic obstructive pulmonary disorder (COPD) as ... and AstraZeneca plc as well as Germany’s Boehringer ... and position. But will market payers, clinicians and ... well-entrenched products to completely new ones? , In ...
(Date:5/22/2015)... 22, 2015 Hands On HealthCare Massage ... 2015, the Annual One Day Sale on Massage ... On HCMT offers drastically reduced certificates one day a year. ... enough sessions, through what used to be the slowest time ... the community as well. This once a year occurrence has ...
(Date:5/22/2015)... 2015 “It’s like learning an ... CHHRP-QT, Vice President of Clinical Operations/Education and Training ... that impacts how care is coded and reimbursed.” ... term care reimbursement, operations and compliance consulting, as ... management, launches a new series of day-long seminars ...
Breaking Medicine News(10 mins):Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 3Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 3
... more attention to choosing the doctor, not the device ... as a safe and long-lasting way to alleviate hip-related ... fails, the problem more often lies with surgical error ... , , Dislocation of the implant was the most common ...
... gene is a key to understanding, and perhaps killing, ... only to reawaken years later, researchers at The University ... the December Journal of Clinical Investigation . , ... ARHI acts as a switch for autophagy, or self-cannibalization, ...
... that Lewy bodies, clumps of aggregated proteins inside ... Parkinson,s disease and other neurodegenerative diseases. , The ... protein recycling and waste disposal, leading to the ... cells? , One possible answer: by breaking a ...
... supplementation was found to be effective in relieving pain ... chronic pancreatitis (CP), reports a new study in ... the pancreas in which patients experience abdominal pain (in ... Pain is the major problem in 90 percent of ...
... from presence of salicylic acid in study participants , , ... key component that gives aspirin its anti-inflammatory and pain-relieving ... own, a new study suggests. , Salicylic acid (SA) ... who had not taken aspirin recently -- especially vegetarians. ...
... organ improved odds, study shows , , WEDNESDAY, Dec. 31 ... donated kidney raised the chances of a successful transplant ... European researchers report. , The study, published in the ... of Medicine , got generally favorable reviews from American ...
Cached Medicine News:Health News:Surgeons Often Are Blamed When Hip Replacements Fail 2Health News:Surgeons Often Are Blamed When Hip Replacements Fail 3Health News:Dormant cancer cells rely on cellular self-cannibalization to survive 2Health News:Toxicity mechanism identified for Parkinson's disease 2Health News:Antioxidants offer pain relief in patients with chronic pancreatitis 2Health News:A Better Method of Kidney Storage 2Health News:A Better Method of Kidney Storage 3
(Date:5/22/2015)... BOTHELL, Wash. , May 22, 2015  BioLife Solutions, ... marketer of proprietary clinical grade hypothermic storage and ... products for cells and tissues ("BioLife" or the "Company"), ... 2015 Marcum MicroCap Conference. The Company is ... on Wednesday, May 27, 2015 at the Grand Hyatt Hotel ...
(Date:5/22/2015)... 22, 2015 The Assistance Fund announces the ... provides financial assistance for copay to individuals diagnosed with ... the addition of the Melanoma Copay Assistance Program to ... , executive director. "With each additional program we are ... world where no one is denied access to medications ...
(Date:5/22/2015)... Electrophysiologist Kevin Makati, M.D. with St. ... Boston, MA to speak about ... Society conference. These scientific sessions drew more than ... people and technology that propel their specialty forward. ... invasive cardiac operation that combines the expertise of ...
Breaking Medicine Technology:BioLife Solutions To Present At The 2015 Marcum MicroCap Conference In New York City 2The Assistance Fund Adds Melanoma Assistance Program 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3
... 1, 2011 Every year thousands of children are hospitalized ... for them. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) Teens share ... by colorful pills that look like candy. ... how you can prevent harm by locking your medicine up. ...
... N.J., Nov. 1, 2011 Quest Diagnostics Incorporated (NYSE: ... diagnostic testing, information and services, today announced the CE ... & RSV Direct test on the 3M™ Integrated Cycler. ... uses a proprietary technique to eliminate nucleic-acid sample extraction, ...
Cached Medicine Technology:Quest Diagnostics Announces Launch of Simplexa™ Direct Test for Influenza and Respiratory Viruses in Europe 2Quest Diagnostics Announces Launch of Simplexa™ Direct Test for Influenza and Respiratory Viruses in Europe 3
... superb field flatness, high UV transmission ... extra long working distances, these objectives ... with inverted microscopes. Because of their ... ELWD DM,objectives can be used universally ...
Inquire...
... Axiovert 40 inverted microscope ... have ever expected from a microscope in this ... quality, and functionality. Axiovert 40 has been designed ... as possible thus increasing the efficiency of ...
... is an advanced inverted microscope ... exclusive CFI60 optical system yields ... aperatures and longer working distances. ... to take full advantage of ...
Medicine Products: