Navigation Links
Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments
Date:11/21/2011

DETROIT Cystic fibrosis, one of the most common chronic lung and digestive system diseases in children and adults, is caused by a defective gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is the deletion of the phenylalanine amino acid residue at position 508 that leads to a defect in the protein transport to the cell surface, resulting in premature digestion of the protein.

A Wayne State University research team led by Fei Sun, Ph.D., assistant professor of physiology in the School of Medicine, recently received a grant with an anticipated amount of nearly $1.9 million from the National Heart, Lung and Blood Institute of the National Institutes of Health to better understand how this defective protein in cystic fibrosis patients is prematurely digested.

"We aim to develop a roadmap for identifying novel therapeutic targets to restore function to this mutation, ultimately alleviating much pain and suffering for many who suffer severe lung and bowel problems because of cystic fibrosis," said Sun.

Nearly 30,000 Americans have cystic fibrosis and another 10 million are carriers of the defective gene, which causes the body to produce a thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections, and obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food. There is no cure for the disease.

"Dr. Sun's research shows great promise in targeting the cystic fibrosis gene that attacks the digestive system," said Hilary Ratner, WSU's vice president for research. "If successful, it may lead to the development of new treatments that ultimately may change this from a life-threatening disease to one that is manageable or even eliminated someday. His research is a great example of the high impact research Wayne State University faculty are engaged in."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Wayne State University to study novel treatment for antibiotic-resistant bacteria
2. Wayne State therapeutic marijuana use study could impact state policies, guide treatment
3. Wayne State creating computer-based drug intervention for at-risk post-partum women
4. Wayne State to develop a computer-delivered intervention for alcohol use during pregnancy
5. Wayne State University study of heroin users to examine links between stress, drug use
6. Wayne State University to study effects of risky family environments on childhood asthma
7. Wayne State researcher developing treatments for Parkinsons with aid of $2.15 million NIH grant
8. Wayne State University study aims to improve diabetes management in high-risk youth
9. Wayne State University partners with Toyota on safety research
10. Wayne State University researcher to study spinal muscular atrophy
11. Wayne State University awarded $3 million from NIH to foster science and research careers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: