Navigation Links
Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments
Date:11/21/2011

DETROIT Cystic fibrosis, one of the most common chronic lung and digestive system diseases in children and adults, is caused by a defective gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is the deletion of the phenylalanine amino acid residue at position 508 that leads to a defect in the protein transport to the cell surface, resulting in premature digestion of the protein.

A Wayne State University research team led by Fei Sun, Ph.D., assistant professor of physiology in the School of Medicine, recently received a grant with an anticipated amount of nearly $1.9 million from the National Heart, Lung and Blood Institute of the National Institutes of Health to better understand how this defective protein in cystic fibrosis patients is prematurely digested.

"We aim to develop a roadmap for identifying novel therapeutic targets to restore function to this mutation, ultimately alleviating much pain and suffering for many who suffer severe lung and bowel problems because of cystic fibrosis," said Sun.

Nearly 30,000 Americans have cystic fibrosis and another 10 million are carriers of the defective gene, which causes the body to produce a thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections, and obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food. There is no cure for the disease.

"Dr. Sun's research shows great promise in targeting the cystic fibrosis gene that attacks the digestive system," said Hilary Ratner, WSU's vice president for research. "If successful, it may lead to the development of new treatments that ultimately may change this from a life-threatening disease to one that is manageable or even eliminated someday. His research is a great example of the high impact research Wayne State University faculty are engaged in."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Wayne State University to study novel treatment for antibiotic-resistant bacteria
2. Wayne State therapeutic marijuana use study could impact state policies, guide treatment
3. Wayne State creating computer-based drug intervention for at-risk post-partum women
4. Wayne State to develop a computer-delivered intervention for alcohol use during pregnancy
5. Wayne State University study of heroin users to examine links between stress, drug use
6. Wayne State University to study effects of risky family environments on childhood asthma
7. Wayne State researcher developing treatments for Parkinsons with aid of $2.15 million NIH grant
8. Wayne State University study aims to improve diabetes management in high-risk youth
9. Wayne State University partners with Toyota on safety research
10. Wayne State University researcher to study spinal muscular atrophy
11. Wayne State University awarded $3 million from NIH to foster science and research careers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
Breaking Medicine Technology: