Navigation Links
Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments
Date:11/21/2011

DETROIT Cystic fibrosis, one of the most common chronic lung and digestive system diseases in children and adults, is caused by a defective gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is the deletion of the phenylalanine amino acid residue at position 508 that leads to a defect in the protein transport to the cell surface, resulting in premature digestion of the protein.

A Wayne State University research team led by Fei Sun, Ph.D., assistant professor of physiology in the School of Medicine, recently received a grant with an anticipated amount of nearly $1.9 million from the National Heart, Lung and Blood Institute of the National Institutes of Health to better understand how this defective protein in cystic fibrosis patients is prematurely digested.

"We aim to develop a roadmap for identifying novel therapeutic targets to restore function to this mutation, ultimately alleviating much pain and suffering for many who suffer severe lung and bowel problems because of cystic fibrosis," said Sun.

Nearly 30,000 Americans have cystic fibrosis and another 10 million are carriers of the defective gene, which causes the body to produce a thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections, and obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food. There is no cure for the disease.

"Dr. Sun's research shows great promise in targeting the cystic fibrosis gene that attacks the digestive system," said Hilary Ratner, WSU's vice president for research. "If successful, it may lead to the development of new treatments that ultimately may change this from a life-threatening disease to one that is manageable or even eliminated someday. His research is a great example of the high impact research Wayne State University faculty are engaged in."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Wayne State University to study novel treatment for antibiotic-resistant bacteria
2. Wayne State therapeutic marijuana use study could impact state policies, guide treatment
3. Wayne State creating computer-based drug intervention for at-risk post-partum women
4. Wayne State to develop a computer-delivered intervention for alcohol use during pregnancy
5. Wayne State University study of heroin users to examine links between stress, drug use
6. Wayne State University to study effects of risky family environments on childhood asthma
7. Wayne State researcher developing treatments for Parkinsons with aid of $2.15 million NIH grant
8. Wayne State University study aims to improve diabetes management in high-risk youth
9. Wayne State University partners with Toyota on safety research
10. Wayne State University researcher to study spinal muscular atrophy
11. Wayne State University awarded $3 million from NIH to foster science and research careers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Displays and Exhibits’ has recently aligned with ... of hanging signs ; making what was formerly an ... from ceiling rigging points at a usual height of 16’-20’ ... These signs are very unique and more visible than ... installation and dismantle labor and rigging the costs far outweigh ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Ready to hit ... important for all drivers to get their vehicles ready. With ... be prepared. Advanced Driving Systems (ADS) is ready to help ... on preparing for summer road trips. , When planning for ... following to ensure that the trip goes smoothly and they ...
(Date:5/29/2015)... PA (PRWEB) May 29, 2015 M3 ... quiz-based learning in 14 medical specialties, now offers ... a wide spectrum of rheumatology disorders ranging from Fibromyalgia ... Saint Jacques, editorial director of MDLinx, and Caroline Tredway, ... about the impact it will have on the physicians ...
(Date:5/29/2015)... 2015 Abington Hospital – Jefferson ... first hospitals in the nation to join the ... practices and work toward achieving the Baby-Friendly USA© ... focusing on maternity care practices leading to Baby-Friendly ... and Prevention, EMPower is aimed at increasing breastfeeding ...
(Date:5/29/2015)... Dot Hill can mark one more item off her bucket list: ... retirement community is the oldest woman to have flown at ... great fun!”, she exclaimed. “I’ve always wanted to jump from ... thought this would be ok.” , “We put on nylon coveralls, ... described. “I don’t remember it being noisy, but the wind ...
Breaking Medicine News(10 mins):Health News:Displays and Exhibits Announces New Hanging Sign Supplier 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 3Health News:MDLinx Launches Smartest Rheumatologist 2Health News:Abington Hospital Selected to Join Baby-Friendly Hospital Initiative 2Health News:Indoor Skydiving Brings Thrills to Seniors 2
... course of corticosteroids to patients after they get discharged from ... relapse. ,Giving the steroids also reduces their ... weeks. ,The study was conducted by a team ... part of the Cochrane Systematic Review. ,As part ...
... Former Palestinian President Yasser Arafat died of AIDS, a rival ... ,Ahmad Jibril, the founder of the Popular Front for the ... Daily News as saying that he received confirmation of this ... ,Jibril said that earlier he had suspected that Israel ...
... is gradually diminishing, and to solve the crisis the sector ... next five years, says an industry body . ,India's ... would require about 2.2 million beds and the investment needed ... Chambers of Commerce and Industry (FICCI) said in a presentation ...
... medicine manufacturing unit was busted in Orissa's Bolangir district and ... Saturday. ,A police team raided a factory ... from here, late Friday and seized the fake drugs, district ... IANS. ,Agarwal confessed that he supplied the fake ...
... four percent of American youths online have been asked to ... ,Researchers at the University of New Hampshire's ... 25 youth who use the Internet got a request to ... of the year. ,This study, published in the ...
... AMA is encouraging young people to feel more comfortable and ... President, Dr Rosanna Capolingua, said today that young people should ... on trust and confidentiality. ,There is a ... young people. They need to know that their GP is ...
Cached Medicine News:Health News:India Requires Over $200 Bn to Provide Quality Healthcare 2Health News:Four Percent of American Youths are Requested to Post Sexual Snaps on Web 2
(Date:5/29/2015)... 2015  Eli Lilly and Company (NYSE: LLY ... that they have entered into a clinical trial collaboration ... investigational anti-PD-L1 immune checkpoint inhibitor, MEDI4736, in combination with ... cancer medicine. The planned study will assess the combination ... The Phase I study is expected to ...
(Date:5/29/2015)... -- World-renowned prostate surgeon and New York Urologist, Dr. David ... MR/Ultrasound Fusion-Guided Biopsy for detecting aggressive prostate cancer ... at Lenox Hill Hospital is the only center using the ... York City . We,ve seen tremendous improvement in detecting ... of an MRI makes for a much more accurate diagnosis, ...
(Date:5/28/2015)... , May 28, 2015  Eli Lilly and Company ... its previously announced cash tender offer for up to $1.6 ... securities. Holders of notes who tendered, and did ... New York City time, on May ... for purchase by Lilly, are eligible to receive the total ...
Breaking Medicine Technology:Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 2Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 3Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 4Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 5Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 6Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 7Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 8Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 9Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 10Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 11Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 12Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 13Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 14MR/Ultrasound Fusion-Guided Biopsy Better Able to Detect Aggressive Prostate Cancer, New Study Says 2Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 2Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 3Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 4Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 5
...  Watson Pharmaceuticals, Inc. (NYSE: WPI ), a ... Olafsson, Watson,s President of Global Generics, will provide an ... Jefferies 2012 Global Healthcare Conference on Monday, June 4, ... in New York, New York.  The presentation will be ...
... May 25, 2012  Marken announced today that it has ... will manage customer service operations and offer local service ... Korea.  Marken currently operates in the country through its ... out of the country.  This new office has been ...
Cached Medicine Technology:Watson to Present at the Jefferies 2012 Global Healthcare Conference 2Marken Opens Branch Office In Seoul, South Korea 2
1.2% Tryptone, 2.4% Yeast Extract, 1.6% Glycerol, 100 ml of 10x Phosphate buffer supplement....
5.0% Casein digest (NZ amine), 2.5% Sodium Chloride, 2.5% Yeast Extract....
1.0% Casein digest (NZ amine), 0.5% Sodium Chloride, 0.5% Yeast Extract, 1.0% bacto casamino acids, 0.2% Mag. Sulfate....
0.5% Yeast Extract, 2.0% Tryp, 10mM Sodium Chloride, 2.5mM Potassium Chloride....
Medicine Products: