Navigation Links
Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments

DETROIT Cystic fibrosis, one of the most common chronic lung and digestive system diseases in children and adults, is caused by a defective gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is the deletion of the phenylalanine amino acid residue at position 508 that leads to a defect in the protein transport to the cell surface, resulting in premature digestion of the protein.

A Wayne State University research team led by Fei Sun, Ph.D., assistant professor of physiology in the School of Medicine, recently received a grant with an anticipated amount of nearly $1.9 million from the National Heart, Lung and Blood Institute of the National Institutes of Health to better understand how this defective protein in cystic fibrosis patients is prematurely digested.

"We aim to develop a roadmap for identifying novel therapeutic targets to restore function to this mutation, ultimately alleviating much pain and suffering for many who suffer severe lung and bowel problems because of cystic fibrosis," said Sun.

Nearly 30,000 Americans have cystic fibrosis and another 10 million are carriers of the defective gene, which causes the body to produce a thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections, and obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food. There is no cure for the disease.

"Dr. Sun's research shows great promise in targeting the cystic fibrosis gene that attacks the digestive system," said Hilary Ratner, WSU's vice president for research. "If successful, it may lead to the development of new treatments that ultimately may change this from a life-threatening disease to one that is manageable or even eliminated someday. His research is a great example of the high impact research Wayne State University faculty are engaged in."


Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Page: 1

Related medicine news :

1. Wayne State University to study novel treatment for antibiotic-resistant bacteria
2. Wayne State therapeutic marijuana use study could impact state policies, guide treatment
3. Wayne State creating computer-based drug intervention for at-risk post-partum women
4. Wayne State to develop a computer-delivered intervention for alcohol use during pregnancy
5. Wayne State University study of heroin users to examine links between stress, drug use
6. Wayne State University to study effects of risky family environments on childhood asthma
7. Wayne State researcher developing treatments for Parkinsons with aid of $2.15 million NIH grant
8. Wayne State University study aims to improve diabetes management in high-risk youth
9. Wayne State University partners with Toyota on safety research
10. Wayne State University researcher to study spinal muscular atrophy
11. Wayne State University awarded $3 million from NIH to foster science and research careers
Post Your Comments:
(Date:11/26/2015)... , ... November 26, 2015 , ... ... set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer ... classically-influenced trailer titles work with any font, giving users limitless opportunities to stylize ...
(Date:11/26/2015)... ... November 26, 2015 , ... Indosoft Inc., developer and distributor of the world-class ... improve system efficiency and reliability. , The new Q-Suite 6 platform is based on ... avoids locking itself into a specific piece of software for many key components of ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... Water For Empowerment ™ attracts volunteers together who want to combine talents ... women as key stakeholders in the process. The non-profit launched its first major ...
(Date:11/25/2015)... MN (PRWEB) , ... November 25, 2015 , ... Finnleo, ... through Christmas Eve on several models of traditional and far-infrared saunas. , ... Nordic Spruce is the most traditional Finnish sauna wood, and Finnleo uses only European ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc , ... accessories. , Sauna accessories help improve the bather experience in the sauna, and ... styles for the purist looking for simplicity in design to accessories that encourage ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... AAIPharma Services Corp./Cambridge Major Laboratories, Inc. ... $15.8  Million to expand its laboratories and global ... The expansion will provide additional office space and ... of the pharmaceutical and biotechnology markets. ... up to 40,000 square feet of expanded development ...
(Date:11/25/2015)... MINNEAPOLIS , Nov. 25, 2015  ARKRAY ... care products, continues to provide evidence demonstrating the accuracy ... the World Congress on Insulin Resistance, Diabetes and Cardiovascular ... showed that both the Company,s GLUCOCARD ® 01 ... met high accuracy requirements. The ability to accurately measure ...
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
Breaking Medicine Technology: