Navigation Links
Wayne State University study predicts risk of memory loss in healthy, older adults
Date:1/19/2011

DETROIT The combined results of a genetic blood test and a five-minute functional MRI successfully classified more than three-quarters of healthy older adults, many of whom were destined to develop cognitive decline within 18 months of testing.

John Woodard, Ph.D., associate professor of psychology in the College of Liberal Arts and Sciences and Institute of Gerontology at Wayne State University, is lead author of "Predicting Cognitive Decline in Healthy Older Adults Using fMRI" published in the Journal of Alzheimer's Disease (vol. 21, no. 3).

"No one had studied these combinations of tests in such a large sample," Woodard said. The results have strong implications for determining who is most likely to benefit from preventive Alzheimer's disease treatments.

Woodard and his colleagues performed five tests on 78 healthy elders: a structural MRI (sMRI) that measures the size of the hippocampal region of the brain; a functional MRI (fMRI) that shows how the brain is activated during mental tasks; a blood test that identifies the APOE ε4 allele (a known genetic marker for Alzheimer's disease); and two standard neuropsychological tests that measure mood and ability.

The most effective combination of tests to predict near-term cognitive decline was the fMRI and the APOE ε4 test. The APOE ε4 allele alone correctly classified 61.5 percent of participants, but the combination of the ε4 allele and low activity on the fMRI test correctly classified 78.9 percent of participants, including 35 percent who showed significant cognitive decline 18 months post-testing.

Age, years of education, gender and family history of dementia were not accurate predictors of future cognitive decline. Dr. Woodard and his colleagues also found that persons with larger hippocampal volume, greater functional brain activity and no APOE ε4 allele were less likely to demonstrate cognitive decline over the following 18 months.

The APOE and fMRI tests that combined as the best predictors are readily available, not time-consuming, and don't require special skills or effort on the part of the participant.

"Use of these tests could play a major role in development of medications for prevention of Alzheimer's and other dementias," Woodard said. "If we can intervene before people become symptomatic, we might be able to slow the progression of the disease or eliminate it altogether."

Alzheimer's is age-correlated; the older the person, the greater the likelihood the person will display symptoms.

"If we could delay the onset of Alzheimer's disease by five years, we could cut the number of new cases in half," Dr. Woodard said. "If we could delay the onset of Alzheimer's disease by 10 years, we could potentially eliminate the disease completely."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. Community Health Systems, Inc.s Wayne T. Smith and Larry Cash Named Americas Top Healthcare CEO and CFO
2. Incidence of cerebal palsy on rise in United States
3. PolicyLink CEO Angela Glover Blackwell Released the Following Statement on First Lady Michelle Obamas Childhood Obesity Initiative
4. Idaho House Moves State Closer to Health Care Disaster
5. Nurse-Attorney/Former Bristol-Myers Squibb Executive Selected To Lead New Jersey State Nurses Association
6. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
7. Advance Toward Test for Aggressive Prostate Cancer
8. Statement from Lawrence Massa, CEO and President, Minnesota Hospital Association
9. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
10. Smithsonian Institution, Arizona State University announce education and research partnership
11. BioMed Realty Trust Promotes Matthew G. McDevitt to Executive Vice President, Real Estate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
Breaking Medicine Technology: