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Wayne State University researchers publish results settling multiple sclerosis debate
Date:2/23/2011

different therapeutic approaches," Tse said.

Studying the possibilities, Tse constructed a special mouse strain to tag the disease-causing T cells and observed that when these marked T cells were eliminated after a relapse, subsequent relapses did not occur.

"Elimination of marked donor T cells could be done after development of the second or the third relapse episodes and each time, no further relapses occurred," said Tse. "This work is significant because for the first time we are able to definitively establish a cause-and-effect relationship linking the marked T cells to the development of relapses and show unambiguously that it was the same T cells that mediated relapsing cycles. "

"Targeting such disease-causing T cells in MS is definitely a valid therapeutic approach that should be pursued," Tse added.


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Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

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