Navigation Links
Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder
Date:4/30/2009

Faculty from the University of Michigan, University of Toronto and Hospital for Sick Kids in Toronto key collaborators in study

DETROIT, April 30 /PRNewswire-USNewswire/ -- Wayne State University medical researchers recently discovered a chemical that plays a major role in children with obsessive-compulsive disorder (OCD).

David Rosenberg, M.D., the Miriam L. Hamburger Endowed Chair of Child Psychiatry and professor of psychiatry in the School of Medicine at Wayne State, collaborated with researchers at the University of Michigan, Children's Hospital of Michigan and University of Toronto/ Hospital for Sick Kids. This international team discovered that the chemical, glutamate, plays a key role in children with OCD.

OCD is a debilitating neuropsychiatric condition that affects approximately 1 to 3 percent of the population worldwide. As many as 80 percent of all OCD cases begin in childhood and adolescence. In Rosenberg's study, children with OCD had abnormal glutamate levels in key brain regions which were reversible with effective treatment.

"Since our initial findings at Wayne State University, basic neuroscience, genetic, brain imaging and novel treatment development studies all converged to show that glutamate has a key role in OCD," said Rosenberg. "If we think of serotonin as analogous to light that lets us see in the dark, glutamate is the brain's light switch or brain modulator which helps turn serotonin and other chemicals off and on."

Wayne State's researchers along with Gregory Hanna, M.D. of the University of Michigan and researchers at the University of Toronto/Hospital for Sick Kids in Toronto, Ontario have a longstanding collaboration and recently published the first OCD study combining brain imaging and genetics studies in the same children with OCD in the March 2009 issue of the journal Brain Imaging and Behavior. All brain images and blood samples were collected at Wayne State with blood samples genetically analyzed in Drs. James Kennedy and Paul Arnold's laboratory at the University of Toronto and Hospital for Sick Kids.

The studies found significant associations between glutamate receptor and transporter genes and abnormal brain volumes in brain regions implicated in OCD such as the thalamus ('grand central station' in the brain), caudate nucleus (brain's secretary), anterior cingulate cortex (brain's arousal center) and orbital prefrontal cortex (brain's executive decision maker).

This work showing glutamate abnormalities in OCD has significant treatment implications. Based in part on initial findings at Wayne State showing glutamate abnormalities in OCD, new treatment approaches using glutamate modulator drugs such as riluzole, which is currently used for treating Lou Gehring's disease, and others have been used in adults and children with OCD. Initial studies have shown great promise, and studies using riluzole are currently being conducted by the National Institute of Mental Health in children with OCD. The trial is ongoing and results are currently unavailable.

"This study at NIMH demonstrates how work first done at Wayne State University not only has scientific implications but has key 'translational' relevance in bringing work from the bench to the bedside with potential clinical ramifications," commented Rosenberg. Wayne State University, the University of Michigan and the University of Toronto/Hospital for Sick Kids in Toronto have recently submitted a Collaborative R01 grant to NIMH which is being considered for funding. Wayne State University is the lead site and coordinating center on this application.

To view the full paper, visit: http://www.springerlink.com/content/c42277h73t771742/?p=ef3e9b3519a845bf86e6fd8575b58696&pi=0

A second paper was recently published online and will be available in the May issue of Psychiatry Research: Neuroimaging by the same team of researchers. This paper continues the team's study of pediatric OCD patients is the first published report examining the relationship between genetic variation and a neurochemical phenotype in OCD. This study found that there is a significant association between variation in a key glutamate receptor gene and glutamate levels in the brain's arousal center, the anterior cingulate cortex. No association was found between genetic markers and brain imaging measures in brain regions not implicated in the pathology of OCD.

To view the full paper, visit: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBW-4VXCFYB-4&_user=147018&_coverDate=05%2F15%2F2009&_alid=907180169&_rdoc=1&_fmt=high&_orig=search&_cdi=5153&_sort=d&_docanchor=&view=c&_ct=4&_acct=C000012179&_version=1&_urlVersion=0&_userid=147018&md5=6f229103592ce48e2cd701b2e81d6986

Along with Rosenberg, collaborators on the projects include Frank P. MacMaster, Yousha Mirza, Phillip Easter, and Michelle Rose of Wayne State University and The Children's Hospital of Michigan; Gregory Hanna, University of Michigan; Paul Daniel Arnold, Hospital of Sick Kids and the University of Toronto; and Margaret A. Richter, Tricia Sicard, Eliza Burroughs and James Kennedy, University of Toronto.

Wayne State University is one of the nation's pre-eminent public research universities in an urban setting, ranking in the top 50 in R & D expenditures of all public universities by the National Science Foundation. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world.


'/>"/>
SOURCE Wayne State University
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Obama Notre Dame Abortion Tension Mounts: Good Friday Protests at White House, and in Dallas, Los Angeles, and Fort Wayne
2. Wayne State University Scientists ID New Biomarker for Prostate Cancer
3. Wayne Dunlap Joins S&R Communications Group as Senior Vice President
4. John Wayne Cancer Institute Auxiliary Honors Award-Winning Actress Bonnie Hunt and Philanthropists Donna & Harvey Rosen at the 24th Annual Odyssey Ball
5. Starkey Hearing Foundation Partners With GRAMMY Foundation(R) to Announce SoundMatters(TM) Initiative: GRAMMY-Nominated Artist Taylor Swift, Along With Emerging Artists Crosby Loggins, Jimmy Wayne and GRAMMY-Nominated Sara Bareilles Lead the Way in the Pr
6. Wayne County Community College District Presents Second Annual Child Car Seat Check Program
7. Elder Abuse Prevention the Focus of Wayne County Medical Society Foundations Annual Chinese New Year Fundraiser
8. Andre Konski, M.D., M.B.A., Accepts Radiation Oncology Position at Wayne State University and the Karmanos Cancer Institute
9. New Zealand Waynes New Resources Development Co., Ltd. Completes Reverse Merger to Go Public in the U.S.
10. Wayne County Medical Society Foundation To Host Holiday Party For Underprivileged Children Saturday
11. First Study of War-Related Mental Disorders Among Iraqis 10 Years Post-Gulf War Published by Researchers at Wayne State University and Basrah University, Iraq
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... West Dermatology is pleased to announce the ... July 17, 2017, Ms. Vu will join West Dermatology’s large network of medical and ... skin cancer , and more. She graduated from the University of Florida College ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... (ACL) offer patients improved quality of life five years after injury, according to ... Annual Meeting in Toronto, Ontario, Canada. The study followed patients for five years ...
(Date:7/20/2017)... Viejo, CA (PRWEB) , ... July 20, 2017 , ... ... when placed between two clips in the FCPX timeline. This effect isolates horizontal and ... transition in this package contains either a rotating or flipping animation and can be ...
(Date:7/20/2017)... ... July 20, 2017 , ... Acute myeloid leukemia (AML) ... progresses rapidly without treatment. Newly diagnosed patients face intense chemotherapy regimens and a ... relapse. With such a challenging diagnosis that requires immediate action, patients and ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... law firm headquartered in Houston, is pleased to announce their expansion to the ... affordable housing experience, directors Alysse Hollis and Ronald Bell, and of counsels, John ...
Breaking Medicine News(10 mins):
(Date:6/30/2017)... , June 30, 2017 In vitro ... the start of May, at least ten diagnostic companies ... private investments, public offerings and a loan facility.  The ... to almost $80 million.  Kalorama Information provides a monthly ... its Diagnostics Knowledge Center. ...
(Date:6/30/2017)... HIGH POINT, N.C. , June 29, 2017  Axium Pharmaceuticals ... innovations for developing improved novel formulations and alternative dosage forms ... ... transmucosal delivery is based on our waterless self-nano emulsifying formula, ... after contact with saliva. We believe the spray will provide ...
(Date:6/27/2017)... , Jun 27, 2017   NuEyes (NuEyes Technologies ... funding to fuel its growth in helping the legally blind ... (Osterhout Design Group), the leading developer of augmented, virtual and ... sits. The undisclosed funding amount was provided by ... Arab Angel, with offices in Abu Dhabi ...
Breaking Medicine Technology: