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Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder
Date:4/30/2009

Faculty from the University of Michigan, University of Toronto and Hospital for Sick Kids in Toronto key collaborators in study

DETROIT, April 30 /PRNewswire-USNewswire/ -- Wayne State University medical researchers recently discovered a chemical that plays a major role in children with obsessive-compulsive disorder (OCD).

David Rosenberg, M.D., the Miriam L. Hamburger Endowed Chair of Child Psychiatry and professor of psychiatry in the School of Medicine at Wayne State, collaborated with researchers at the University of Michigan, Children's Hospital of Michigan and University of Toronto/ Hospital for Sick Kids. This international team discovered that the chemical, glutamate, plays a key role in children with OCD.

OCD is a debilitating neuropsychiatric condition that affects approximately 1 to 3 percent of the population worldwide. As many as 80 percent of all OCD cases begin in childhood and adolescence. In Rosenberg's study, children with OCD had abnormal glutamate levels in key brain regions which were reversible with effective treatment.

"Since our initial findings at Wayne State University, basic neuroscience, genetic, brain imaging and novel treatment development studies all converged to show that glutamate has a key role in OCD," said Rosenberg. "If we think of serotonin as analogous to light that lets us see in the dark, glutamate is the brain's light switch or brain modulator which helps turn serotonin and other chemicals off and on."

Wayne State's researchers along with Gregory Hanna, M.D. of the University of Michigan and researchers at the University of Toronto/Hospital for Sick Kids in Toronto, Ontario have a longstanding collaboration and recently published the first OCD study combining brain imaging and genetics studies in the same children w
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SOURCE Wayne State University
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