Navigation Links
Way to Rescue Tired Immune Cells Fighting HIV Found
Date:11/12/2008

Discovery of pathway could lead to new treatments, researchers say

WEDNESDAY, Nov. 12 (HealthDay News) -- A method of "rescuing" immune cells exhausted from fighting HIV infection has been discovered by American and Canadian researchers.

They found that a molecule called Tim-3 is present at high levels in poorly functioning immune cells worn out from combating HIV, the virus that causes AIDS. Blocking the activity of Tim-3 improved the function of these cells, so that they could jump back into the fight against HIV infection, said the University of California, San Francisco (UCSF), and University of Toronto researchers.

"In the typical course of HIV infection, an initial burst of very high levels of the HIV virus is brought partially under control by the infected person's immune system, specifically by an immune system cell called a CD8+ killer T-cell. In the majority of cases without antiretroviral drug treatment, the immune system is eventually overwhelmed, and progression to AIDS occurs," co-principal author Brad Jones, a doctoral candidate in immunology at the University of Toronto, said in a news release about the study.

In a group of HIV-infected patients, the researchers observed that Tim-3 expression on CD8+ T-cells was associated with clinical parameters of HIV disease progression. This led them to believe that manipulation of the Tim-3 pathway may provide a new approach to HIV treatment.

To test their theory, they developed a molecule that blocks the Tim-3 signal and studied its effect on CD8+ T-cells in the laboratory. They found that blocking the Tim-3 pathway rescued the immune cells and restored their ability to fight infection.

The study was expected to be published in the Nov. 24 issue of the Journal of Experimental Medicine.

"We still do not know how the virus triggers Tim-3 or if this is restricted to HIV infection, but our findings may provide a new direction to vaccines and therapies that will potentially reverse these dysfunctional cells and allow them to control HIV-1 replication," co-principal author Lishomwa Ndhlovu, of the division of experimental medicine at UCSF, said in the news release.

"Our hope is this will enable those infected with HIV to turn the tide in the long battle between the immune system and HIV. Future studies which block Tim-3 signaling in animal models of chronic viral infection will help to evaluate the therapeutic potential of this approach," Jones added.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, Nov. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Natural Disaster Rescue Teams at Public Health Facilities Across the Country Learn from Katrina Failures
2. Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs Theyre Not Aware of
3. Scientists from Europe, Israel and the US develop robotic rats to aid in rescue missions
4. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
5. Michael Moore Defends 9/11 Rescue Workers and Criticizes Insurance Industry on California Nurses Association Press Call
6. Road Rescue Introduces Patient-Centric Concept Ambulance at FDIC
7. Can Wireless Technologies Rescue U.S. Hospitals?
8. International Rescue Committee Mobilizes More Emergency Teams for Myanmar; Warns of Massive Health Disaster Unless Aid Reaches Cyclone Survivors Fast
9. Surgeon operates to rescue chimp with rare deformity
10. Generation Rescue to Target Treatment-Based Research for Autism and ADHD - Jenny McCarthy, Deirdre Imus, and Katie Wright Join Board
11. Why some treatments rescue aging skin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Way to Rescue Tired  Immune Cells Fighting HIV Found 
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: