Navigation Links
Way to Rescue Tired Immune Cells Fighting HIV Found
Date:11/12/2008

Discovery of pathway could lead to new treatments, researchers say

WEDNESDAY, Nov. 12 (HealthDay News) -- A method of "rescuing" immune cells exhausted from fighting HIV infection has been discovered by American and Canadian researchers.

They found that a molecule called Tim-3 is present at high levels in poorly functioning immune cells worn out from combating HIV, the virus that causes AIDS. Blocking the activity of Tim-3 improved the function of these cells, so that they could jump back into the fight against HIV infection, said the University of California, San Francisco (UCSF), and University of Toronto researchers.

"In the typical course of HIV infection, an initial burst of very high levels of the HIV virus is brought partially under control by the infected person's immune system, specifically by an immune system cell called a CD8+ killer T-cell. In the majority of cases without antiretroviral drug treatment, the immune system is eventually overwhelmed, and progression to AIDS occurs," co-principal author Brad Jones, a doctoral candidate in immunology at the University of Toronto, said in a news release about the study.

In a group of HIV-infected patients, the researchers observed that Tim-3 expression on CD8+ T-cells was associated with clinical parameters of HIV disease progression. This led them to believe that manipulation of the Tim-3 pathway may provide a new approach to HIV treatment.

To test their theory, they developed a molecule that blocks the Tim-3 signal and studied its effect on CD8+ T-cells in the laboratory. They found that blocking the Tim-3 pathway rescued the immune cells and restored their ability to fight infection.

The study was expected to be published in the Nov. 24 issue of the Journal of Experimental Medicine.

"We still do not know how the virus triggers Tim-3 or if this is restricted to HIV infection, but our findings may provide a new direction to vaccines and therapies that will potentially reverse these dysfunctional cells and allow them to control HIV-1 replication," co-principal author Lishomwa Ndhlovu, of the division of experimental medicine at UCSF, said in the news release.

"Our hope is this will enable those infected with HIV to turn the tide in the long battle between the immune system and HIV. Future studies which block Tim-3 signaling in animal models of chronic viral infection will help to evaluate the therapeutic potential of this approach," Jones added.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, Nov. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Natural Disaster Rescue Teams at Public Health Facilities Across the Country Learn from Katrina Failures
2. Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs Theyre Not Aware of
3. Scientists from Europe, Israel and the US develop robotic rats to aid in rescue missions
4. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
5. Michael Moore Defends 9/11 Rescue Workers and Criticizes Insurance Industry on California Nurses Association Press Call
6. Road Rescue Introduces Patient-Centric Concept Ambulance at FDIC
7. Can Wireless Technologies Rescue U.S. Hospitals?
8. International Rescue Committee Mobilizes More Emergency Teams for Myanmar; Warns of Massive Health Disaster Unless Aid Reaches Cyclone Survivors Fast
9. Surgeon operates to rescue chimp with rare deformity
10. Generation Rescue to Target Treatment-Based Research for Autism and ADHD - Jenny McCarthy, Deirdre Imus, and Katie Wright Join Board
11. Why some treatments rescue aging skin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Way to Rescue Tired  Immune Cells Fighting HIV Found 
(Date:1/20/2017)... ... January 20, 2017 , ... Michael and Betsy Brauser ... Cancer Institute. For Betsy, the clinical trial has been life-saving as she has ... worsened. , Betsy Brauser was diagnosed with ovarian cancer in 2009. She underwent ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Mary Magdalene: Grace is ... life of the woman who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is Greater ... spent her career as an educator interacting with countless women who had little knowledge ...
(Date:1/20/2017)... ... ... a fine examination of how God handles sin, including how to let go of ... who, for over ten long years has been waiting to release this powerful insight about ... has been serving the Lord for over twenty years, and he has been preaching and ...
(Date:1/20/2017)... ... ... and enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is ... a devoted woman of faith. , “Becoming a parent changes you. In my case, ... for years, but actually doing it might have been a while in coming if it ...
(Date:1/20/2017)... ... , ... “God's Miracle Man: Against All Odds”: an inspiring affirmation of ... Keith C. A. Tucker, son of Minister Delores Pinnock and a Jamaican native who ... Hardy , “While sitting up in bed, I felt a pounding headache. It was ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Report Details ... Alzheimer,s Disease Therapeutics and ... our new study reveals trends, R&D progress, and predicted ... the Alzheimer,s disease therapeutics and diagnostics market. Our new ... - How is the Alzheimer,s disease therapeutics and diagnostics ...
(Date:1/19/2017)... , January 19, 2017 Incretin Mimetics/GLP-1 ... and Others The global anti-obesity drugs market ... first half of the forecast period and CAGR of 38.7% in ... to grow at a CAGR of 32.8% from 2016 to 2027. ... in 2021, and $24,063 million in 2027. ...
(Date:1/19/2017)... -- James Gilbart , ... 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ...      ... in a supplement to European Oncology & Haematology ... by James Gilbart and Axel ...
Breaking Medicine Technology: