Navigation Links
Way to Rescue Tired Immune Cells Fighting HIV Found
Date:11/12/2008

Discovery of pathway could lead to new treatments, researchers say

WEDNESDAY, Nov. 12 (HealthDay News) -- A method of "rescuing" immune cells exhausted from fighting HIV infection has been discovered by American and Canadian researchers.

They found that a molecule called Tim-3 is present at high levels in poorly functioning immune cells worn out from combating HIV, the virus that causes AIDS. Blocking the activity of Tim-3 improved the function of these cells, so that they could jump back into the fight against HIV infection, said the University of California, San Francisco (UCSF), and University of Toronto researchers.

"In the typical course of HIV infection, an initial burst of very high levels of the HIV virus is brought partially under control by the infected person's immune system, specifically by an immune system cell called a CD8+ killer T-cell. In the majority of cases without antiretroviral drug treatment, the immune system is eventually overwhelmed, and progression to AIDS occurs," co-principal author Brad Jones, a doctoral candidate in immunology at the University of Toronto, said in a news release about the study.

In a group of HIV-infected patients, the researchers observed that Tim-3 expression on CD8+ T-cells was associated with clinical parameters of HIV disease progression. This led them to believe that manipulation of the Tim-3 pathway may provide a new approach to HIV treatment.

To test their theory, they developed a molecule that blocks the Tim-3 signal and studied its effect on CD8+ T-cells in the laboratory. They found that blocking the Tim-3 pathway rescued the immune cells and restored their ability to fight infection.

The study was expected to be published in the Nov. 24 issue of the Journal of Experimental Medicine.

"We still do not know how the virus triggers Tim-3 or if this is restricted to HIV infection, but our findings may provide a new direction to vaccines and therapies that will potentially reverse these dysfunctional cells and allow them to control HIV-1 replication," co-principal author Lishomwa Ndhlovu, of the division of experimental medicine at UCSF, said in the news release.

"Our hope is this will enable those infected with HIV to turn the tide in the long battle between the immune system and HIV. Future studies which block Tim-3 signaling in animal models of chronic viral infection will help to evaluate the therapeutic potential of this approach," Jones added.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.



-- Robert Preidt



SOURCE: University of California, San Francisco, news release, Nov. 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Natural Disaster Rescue Teams at Public Health Facilities Across the Country Learn from Katrina Failures
2. Internet Comes to Rescue of 14 Million Uninsured in U.S.; Providing Access to Gov. Health Programs Theyre Not Aware of
3. Scientists from Europe, Israel and the US develop robotic rats to aid in rescue missions
4. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
5. Michael Moore Defends 9/11 Rescue Workers and Criticizes Insurance Industry on California Nurses Association Press Call
6. Road Rescue Introduces Patient-Centric Concept Ambulance at FDIC
7. Can Wireless Technologies Rescue U.S. Hospitals?
8. International Rescue Committee Mobilizes More Emergency Teams for Myanmar; Warns of Massive Health Disaster Unless Aid Reaches Cyclone Survivors Fast
9. Surgeon operates to rescue chimp with rare deformity
10. Generation Rescue to Target Treatment-Based Research for Autism and ADHD - Jenny McCarthy, Deirdre Imus, and Katie Wright Join Board
11. Why some treatments rescue aging skin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Way to Rescue Tired  Immune Cells Fighting HIV Found 
(Date:9/22/2017)... ... September 22, 2017 , ... First Choice ... celebrating the one year anniversary of its Houston-Fallbrook facility. , “We are ... Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It has been a ...
(Date:9/22/2017)... ... ... “Letters From Home”: a moving compilation of letters that remind readers of the ... is the creation of published author, John Allred, a passionate leader of ministry to ... who has traveled and ministered on four continents. , “It is my hope and ...
(Date:9/21/2017)... , ... September 21, 2017 , ... With ProSlideshow Portrait ... and easy to do. Users can select from up to two layers of subject ... click of a mouse all within Final Cut Pro X. , With ...
(Date:9/21/2017)... , ... September 21, 2017 , ... ... learn with Infinity Behavioral Health Services for professionals in the addiction treatment industry ... Payer Audit . , Insurance companies and state and federal governments are ...
(Date:9/21/2017)... ... September 21, 2017 , ... Bill Howe Plumbing’s mission is to create an ... to the community. For over 37 years, they have operated with their mission at ... in San Diego. They were chosen as the Best San Diego plumber in ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... , Sept. 13, 2017   OrthoAtlanta has ... the Atlanta Football Host Committee (AFHC) for the 2018 College ... Jan. 8, 2018, at Mercedes-Benz Stadium in Atlanta, ... of the AFHC "I,m In" campaign, participating in many activities ... ...
(Date:9/9/2017)... , Sept. 8, 2017 Dealmed Medical ... independent supplier of medical equipment, supplies, drugs, vaccines, and ... has entered into an agreement to acquire Vantage Medical ... based in Holtsville, New York . ... in supplying new and emerging medical practices, will operate ...
(Date:9/7/2017)... , Sept. 7, 2017 NuvoAir (formerly ... Spirometer, announced today a partnership with Novartis Pharma AG to ... NuvoAir,s position as the leading mobile spirometry platform and Novartis, ... ... ...
Breaking Medicine Technology: