Navigation Links
Warwick scientists uncover how 'checkpoint' proteins bind chromosomes
Date:4/20/2012

The development of more effective cancer drugs could be a step nearer thanks to the discovery, by scientists at Warwick Medical School, of how an inbuilt 'security check' operates to guarantee cells divide with the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. The process of chromosome segregation is monitored by a system called the spindle checkpoint that ensures daughter cells receive the correct number of chromosomes.

If daughter cells receive an unequal number of chromosomes, known as 'aneuploidy', this drives normal cells to become cancerous. Indeed, the cells of aggressive human tumours are frequently 'aneuploid' with many components of the spindle checkpoint being mutated or mis-expressed. Therefore, determining how the spindle checkpoint operates is vital to understanding what causes, and what can prevent, the formation of tumours.

Current Biology has published research by Professor Jonathan Millar at the University of Warwick that pinpoints the precise mechanism by which spindle checkpoint proteins bind chromosomes.

Professor Millar explained: "Components of the spindle assembly checkpoint were first discovered 22 years ago by researchers in America and yet, until now, the binding sites for these proteins on chromosomes have remained unknown. We have been able to answer this question and as a result, we are now in a much better position to design more selective and effective drugs."

Currently, one of the most frequently used anti-cancer drugs are taxanes, which prevent proper inactivation of the spindle checkpoint and result in selective death of cancer, but not normal, cells. However, this class of drug can have debilitating side effects including permanent neurological damage and hair loss side effects that could be reduced if cancer cells could be targeted more selectively.

Professor Millar was quick to p
'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Warwick joins $3.4 million Anglo-Canadian quest for new weapons in war against antibiotic resistance
2. Warwick scientists discover how daughter cells receive the same number of chromosomes
3. Scientists rewrite rulebook on breast cancer in landmark global study
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists solving the mystery of human consciousness
8. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
9. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
10. Scientists study link between amyloid beta peptide levels and Alzheimers disease
11. Scientists measure how energy is spent in martial arts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... August 30, 2014 Patients suffering from ... disorder in a new review published by Daily Gossip. ... deal with, so there is no wonder that numerous ... The Natural Vitiligo Treatment is one of the most ... Vitiligo Treatment promises to stop the spread of this ...
(Date:8/30/2014)... 30, 2014 Daily Gossip magazine reveals ... anxiety and panic attacks under control with a simple ... review describes this new method as an anxiety ... attacks and overcome general anxiety related disorders. , ... the fact that it can be accessed by users ...
(Date:8/30/2014)... The Plastic Surgery Group (PSG) is one ... in the U.S. to provide clients with Vanquish, a ... waists with deep-tissue heating. , Unlike Cryotherapy which kills ... more inclusive to target large sections of desired weight ... about one inch away from their body while the ...
(Date:8/30/2014)... RB SEO Services, a well-recognized internet marketing ... businesses. , RBSEO Services knows this very well that ... optimization service. So, the company has introduced this service, ... , On being asked about the service, a senior ... SEO service because many small businesses expressed their inability ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 The ... the planet has been one of the main ... to create a positive impact around the world. ... staffed with top trained executives and trainers deliver ... people worldwide. Vital statistics demonstrate that significant ...
Breaking Medicine News(10 mins):Health News:Natural Vitiligo Treatment Review Exposes Fast Method for Skin Repigmentation 2Health News:Panic Away Review Reveals New Natural Remedy for Anxiety Patients 2Health News:NJ Top Docs Presents, The Plastic Surgery Group 2Health News:RBSEO Services Introduces Low Cost SEO Service for Small Businesses 2Health News:Cradle of Aviation Museum Opens Its Doors to Long Island Scientologists 2
... Using new genetic information, scientists have linked a ... and reduced risk of bladder cancer, according to findings ... April 2-6, and simultaneously published in Cancer Prevention Research, ... Jian Gu, Ph.D., assistant professor of epidemiology ...
... , SATURDAY, April 2 (HealthDay News) -- Reducing cancer ... finds. Researchers investigated whether chronic stress associated with ... the ends of chromosomes protect the chromosome from deteriorating, ... lead to mutations. The investigators also wanted to ...
... 02 April 2011: Exciting new data presented today at ... in chronic hepatitis C (HCV) patients suppressed the emergence ... of sustained virological response - undetectable HCV RNA - ... therapy study, HCV patients were given four drugs in ...
... 1 (HealthDay News) -- It,s important to keep injury prevention ... Steven Greer, of the MCGHealth Sports Medicine Center in Augusta, ... All children should undergo a physical examination before they ... extended period of time, they should begin increasing their ...
... in children,s health will be presented in Denver April 30-May ... Academic Societies (PAS). This year,s gathering is a joint meeting ... than 6,500 leaders in academic pediatrics from around the world ... Center. Journalists will have access to hundreds of ...
... FRIDAY, April 1 (HealthDay News) -- Ballet and other types ... on certain parts of the body, so it,s critical to ... of Orthopaedic Surgeons. "When it comes to sports injuries, ... of the matter is that ballet is incredibly demanding on ...
Cached Medicine News:Health News:Genetic variation linked to longer telomeres and lower risk of bladder cancer 2Health News:Does Stress Reduction Benefit Cancer Patients' Health? 2Health News:Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment 2Health News:Tips for Keeping Young Athletes Safe 2Health News:Children's health is focus of annual meeting of Pediatric Academic Societies 2Health News:Rigors of Ballet Require Careful Training 2
(Date:8/29/2014)... 2014   Mast Therapeutics, Inc. (NYSE ... that Santosh Vetticaden, Chief Medical Officer and Senior ... personal reasons, in mid-September.  Edwin L. Parsley ... Pharmaceuticals, which Mast acquired earlier this year, will ... interim Chief Medical Officer.  Dr. Parsley previously was ...
(Date:8/29/2014)... Research and Markets has announced the addition ... report to their offering. Benefiting ... for medical expenses, the Chinese orthopedic instrument market demand ... CAGR of 19.2% during 2009-2013. Trauma products, spine products ... instruments in China , of which ...
(Date:8/29/2014)... DENVER , Aug. 29, 2014 Does your ... date, nearly 800 doctors have recommended marijuana to the over ... Amendment 20. But the majority of the other roughly 20,300+ ... still know very little about it – even though a ... adults say they have tried it. ...
Breaking Medicine Technology:Mast Therapeutics Announces Management Change 2Mast Therapeutics Announces Management Change 3Mast Therapeutics Announces Management Change 4China Orthopedic Instrument Industry Report, 2014-2017 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4
... When the ODT Forum is held in Memphis on ... to shape industry innovation, standards and methods. The ODT Forum ... orthopedic device manufacturers can discuss the critical issues they face ... be held at the FedEx Institute of Technology and will ...
... Feb. 10, 2011 USANA Health Sciences, Inc. ... that nutritional gaps are common in the average American diet ... filling those gaps.  However, USANA scientists and advising physicians caution ... published Dietary Guidelines for Americans, 2010 ...
Cached Medicine Technology:ODT Forum Returns to Memphis with Unique Opportunity for Orthopedic Manufacturers 2USDA Recognizes Benefit of Supplements in New Dietary Guidelines But Doesn't Go Far Enough 2
... The BioPlex 2200 system is ... platform that can deliver up to ... will initially include a panel of ... in development are in the areas ...
... ASR contains primers and a FAM-labeled probe targeting ... as well as primers and an Alexa 532-labeled ... of HSV Type 2. This ASR requires an ... Alexa reporter dyes like the Cepheid SmartCycler System. ...
... and a FAM-labeled probe that is designed to ... Type 1 and Type 2 polymerase gene. This ... FAM reporter dye like the Cepheid SmartCycler System. ... is comprised of a series of easy-to-use primer ...
... The Stratus CS Analyzer, designed for Acute Care ... your laboratory and near patient setting. It's a ... or D-Dimer results from a whole blood sample ... 3 step process load sample and rotor, ...
Medicine Products: