Navigation Links
Warwick scientists uncover how 'checkpoint' proteins bind chromosomes
Date:4/20/2012

The development of more effective cancer drugs could be a step nearer thanks to the discovery, by scientists at Warwick Medical School, of how an inbuilt 'security check' operates to guarantee cells divide with the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. The process of chromosome segregation is monitored by a system called the spindle checkpoint that ensures daughter cells receive the correct number of chromosomes.

If daughter cells receive an unequal number of chromosomes, known as 'aneuploidy', this drives normal cells to become cancerous. Indeed, the cells of aggressive human tumours are frequently 'aneuploid' with many components of the spindle checkpoint being mutated or mis-expressed. Therefore, determining how the spindle checkpoint operates is vital to understanding what causes, and what can prevent, the formation of tumours.

Current Biology has published research by Professor Jonathan Millar at the University of Warwick that pinpoints the precise mechanism by which spindle checkpoint proteins bind chromosomes.

Professor Millar explained: "Components of the spindle assembly checkpoint were first discovered 22 years ago by researchers in America and yet, until now, the binding sites for these proteins on chromosomes have remained unknown. We have been able to answer this question and as a result, we are now in a much better position to design more selective and effective drugs."

Currently, one of the most frequently used anti-cancer drugs are taxanes, which prevent proper inactivation of the spindle checkpoint and result in selective death of cancer, but not normal, cells. However, this class of drug can have debilitating side effects including permanent neurological damage and hair loss side effects that could be reduced if cancer cells could be targeted more selectively.

Professor Millar was quick to p
'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Warwick joins $3.4 million Anglo-Canadian quest for new weapons in war against antibiotic resistance
2. Warwick scientists discover how daughter cells receive the same number of chromosomes
3. Scientists rewrite rulebook on breast cancer in landmark global study
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists solving the mystery of human consciousness
8. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
9. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
10. Scientists study link between amyloid beta peptide levels and Alzheimers disease
11. Scientists measure how energy is spent in martial arts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... Multi Customer Discount , Rules: This special ... ) of 1000-1500 gallons in Zeiter's Septics service area. ... not include any Dig fees, or any other fees, ... someone is part of this group event and has ... gallons or more, the cost would be $300.00. These ...
(Date:4/24/2015)... Ryadon is a leading manufacturer of custom ... services to complement any custom hardware requirements you may ... be offered on all heavy duty drawer slides ( ... discount - Order 20+: Receive 20% discount , Industries ... Furniture ,Drawer Slides, Inc. ...
(Date:4/24/2015)... The Fastest Fat Loss Week Ever, released by ... the Xtreme Fat Loss Diet, has been causing a lot ... that claims to help one lose belly fat in only ... prompting an investigative review. , "Our Fastest Fat Loss ... researching and experimenting with these methods on their clients with ...
(Date:4/24/2015)... Denver, CO (PRWEB) April 24, 2015 ... and have toured almost constantly across the globe to theaters, ... their home in Manchester, they’ve partnered with their label, Dirty ... need. , Teaming up with the newly launched Cadence ... first-press of their debut LP on vinyl and a signed ...
(Date:4/24/2015)... The first step to transforming one’s ... For meditation and yoga teacher Stine Koppernæs, meditation and ... tools that allow her to experience more peace and ... a teacher since 2006, and through the years she ... being. , “I love sharing this way of finding ...
Breaking Medicine News(10 mins):Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Fastest Fat Loss Week Ever Review Revealed on Healthy & Fit Zone 2Health News:Internationally Recognized British Indie Rock Outfit The 1975 Partner with Cadence & Cause to Provide Clean Drinking Water to Those in Need 2
... June 18 Doctors in the Netherlands have developed ... using fast and precise RapidArc(TM) radiotherapy technology from Varian ... among the findings in several papers published by the ... , , Radiation oncologist Dr. Frank Lagerwaard and ...
... 2009 Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) ... present at the Piper Jaffray Fourth Annual Europe Conference on ... am Eastern Time, 1:30 a.m. Pacific Time) at the Andaz ... Senior Vice President and Chief Scientific Officer, is scheduled to ...
... Md., June 18 Micromet, Inc. (Nasdaq: ... proprietary antibodies for the treatment of cancer, inflammation ... the first clinical trial for the anti-granulocyte macrophage ... collaboration partner Nycomed. , , The double-blind, ...
... ... Ovu-Trac®, an Ovulation Predictor Kit now available in the United States ... accuracy. This fertility predictor has been used successfully by tens of ... Administration requirements for legal sale in the United States. The kit allows ...
... ... scheduled to take place in Summit, NJ on September 24th and September 25th, 2009, ... developments in discovery research, preclinical development, clinical development, regulatory issues and real-world pain management ... ...
... 2007, the progress made in the 1990s and early ... pregnancy and childbearing stalled, and may even have reversed ... "Changing Behavior Risk for Pregnancy Among High School Students ... MD, MPH, professor and chair of the Heilbrunn Department ...
Cached Medicine News:Health News:Varian's RapidArc Radiotherapy Technology Enables Pioneering Cancer Treatments at Top Dutch Oncology Center 2Health News:Varian's RapidArc Radiotherapy Technology Enables Pioneering Cancer Treatments at Top Dutch Oncology Center 3Health News:Arena Pharmaceuticals to Present at the Piper Jaffray Fourth Annual Europe Conference 2Health News:Arena Pharmaceuticals to Present at the Piper Jaffray Fourth Annual Europe Conference 3Health News:Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203 2Health News:Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203 3Health News:Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203 4Health News:Ovu-Trac(R) Home Test Kit From OvumOptics Predicts Ovulation with 96.2% Accuracy 2Health News:Ovu-Trac(R) Home Test Kit From OvumOptics Predicts Ovulation with 96.2% Accuracy 3Health News:Ovu-Trac(R) Home Test Kit From OvumOptics Predicts Ovulation with 96.2% Accuracy 4Health News:Leaders from the Field of Pain Therapeutics to Discuss Latest Discoveries and Breakthroughs at Arrowhead's 3rd Annual Pain Therapeutics Summit 2Health News:Leaders from the Field of Pain Therapeutics to Discuss Latest Discoveries and Breakthroughs at Arrowhead's 3rd Annual Pain Therapeutics Summit 3Health News:Leaders from the Field of Pain Therapeutics to Discuss Latest Discoveries and Breakthroughs at Arrowhead's 3rd Annual Pain Therapeutics Summit 4Health News:Teens are heading in wrong direction: Likely to have sex, but not use contraception 2
(Date:4/23/2015)... DUBLIN , April 23, 2015  Jazz Pharmaceuticals ... will report its 2015 first quarter financial results on ... financial markets.  Company management will host a live audio ... p.m. IST to discuss first quarter 2015 financial results ... Interested parties may access the live audio webcast via ...
(Date:4/23/2015)... Colo. , Apr. 23, 2015 Surna, ... manufactures, and distributes state-of-the art equipment and systems ... in commercial indoor cannabis cultivation, will host a ... Monday, April 27, 2015, at 4:15 PM Eastern ... The conference call will be listen-in only, ...
(Date:4/23/2015)... 2015 Holographic Optical Technologies, innovator in ... Voxgram hologram technology available to the consumer market ... https://www.kickstarter.com/projects/629071847/holographic-optical-technologies?ref=nav_search The company is ... the eight-inch Voxbox hologram viewer. This product is ... established, medical-grade unit, the Voxbox Pro. ...
Breaking Medicine Technology:Jazz Pharmaceuticals to Report 2015 First Quarter Financial Results on May 7, 2015 2Surna, Inc. Announces Shareholder Conference Call 2Surna, Inc. Announces Shareholder Conference Call 3Holographic Optical Technologies Launches Kickstarter, Offering True 3D Holograms 2
... Pa., Jan. 4, 2012  Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL) ... 30th Annual J.P. Morgan Healthcare Conference to be held ... in San Francisco, CA.  Mr. Adrian Adams, Chief Executive ... of the Company and its product pipeline at 2:00 ...
... /PRNewswire-iReach/ -- DFH Pharma, Inc., (DFH) ... in the HIV-1 therapeutic space, announced today the ... services to support DFH efforts to develop the ... inhibitors are a novel class of antiretroviral drug ...
Cached Medicine Technology:Auxilium Pharmaceuticals to Present at the 30th Annual J.P. Morgan Healthcare Conference 2Auxilium Pharmaceuticals to Present at the 30th Annual J.P. Morgan Healthcare Conference 3Auxilium Pharmaceuticals to Present at the 30th Annual J.P. Morgan Healthcare Conference 4DFH Pharma to Collaborate with CiVentiChem to Develop Second-Generation HIV Maturation Inhibitor Drugs 2DFH Pharma to Collaborate with CiVentiChem to Develop Second-Generation HIV Maturation Inhibitor Drugs 3
... The Equalizer With 384 Well Plate Capability ... revolutionary features of the original Equalizerexpandable and equal ... components, and in-lab calibration capabilities. In addition, this ... down to 4.5mm for loading and accessing many ...
... Equally Spaced, Expandable, Multichannel Pipettor ... and instantly boosts productivity with an industry ... simple adjustment of a slide rod. This ... of liquids between vessels with different configurations. ...
... Spaced, Expandable, Multichannel Pipettor The ... boosts productivity with an industry breakthroughequal tip ... of a slide rod. This innovation allows ... between vessels with different configurations. Adjustable ...
... Comfort Pick one of our pipettors up ... trigger and ejector positionsright where they should beeven ... ergonomically designed to help avoid repetitive stress injuries ... In The Palm Of Your Hand Start ...
Medicine Products: