Navigation Links
Warwick scientists uncover how 'checkpoint' proteins bind chromosomes
Date:4/20/2012

The development of more effective cancer drugs could be a step nearer thanks to the discovery, by scientists at Warwick Medical School, of how an inbuilt 'security check' operates to guarantee cells divide with the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. The process of chromosome segregation is monitored by a system called the spindle checkpoint that ensures daughter cells receive the correct number of chromosomes.

If daughter cells receive an unequal number of chromosomes, known as 'aneuploidy', this drives normal cells to become cancerous. Indeed, the cells of aggressive human tumours are frequently 'aneuploid' with many components of the spindle checkpoint being mutated or mis-expressed. Therefore, determining how the spindle checkpoint operates is vital to understanding what causes, and what can prevent, the formation of tumours.

Current Biology has published research by Professor Jonathan Millar at the University of Warwick that pinpoints the precise mechanism by which spindle checkpoint proteins bind chromosomes.

Professor Millar explained: "Components of the spindle assembly checkpoint were first discovered 22 years ago by researchers in America and yet, until now, the binding sites for these proteins on chromosomes have remained unknown. We have been able to answer this question and as a result, we are now in a much better position to design more selective and effective drugs."

Currently, one of the most frequently used anti-cancer drugs are taxanes, which prevent proper inactivation of the spindle checkpoint and result in selective death of cancer, but not normal, cells. However, this class of drug can have debilitating side effects including permanent neurological damage and hair loss side effects that could be reduced if cancer cells could be targeted more selectively.

Professor Millar was quick to point out that this is not an overnight cure: "This research is a significant advance in our understanding of how the spindle checkpoint operates but it is really just the start. More research has to be done before we can convert this into a commercial treatment for patients. But we are greatly encouraged that our research here at Warwick is leading the way in the search for more effective cancer drugs."


'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Related medicine news :

1. Warwick joins $3.4 million Anglo-Canadian quest for new weapons in war against antibiotic resistance
2. Warwick scientists discover how daughter cells receive the same number of chromosomes
3. Scientists rewrite rulebook on breast cancer in landmark global study
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists solving the mystery of human consciousness
8. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
9. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
10. Scientists study link between amyloid beta peptide levels and Alzheimers disease
11. Scientists measure how energy is spent in martial arts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2020)... ... September 01, 2020 , ... Feeding Matters , the first organization ... Feeding Disorder (PFD), is pleased to announce that the U.S. Centers for Disease Control ... code) in the next edition of the U.S. International Classification of Diseases (ICD ...
(Date:8/31/2020)... ... 31, 2020 , ... The Lymphoma Research Foundation (LRF) ... research and serving the lymphoma community through a comprehensive series of education programs, ... Cancer Awareness Month (BCAM) and its international Light it Red for Lymphoma ...
(Date:8/31/2020)... N.J. (PRWEB) , ... August 31, 2020 , ... ... leading cloud-based business management solution for chiropractors, announced today the launch of its ... healthcare professionals can start running their virtual practice in under 90 seconds. ...
(Date:8/31/2020)... ... ... Covid-19 “PTS” with Mediation & Hypnosis , At this very turbulent time in the ... anxiety, immense stress, and right now are needing serious relief from a constant state of ... are experiencing a great degree of emotional discomfort, be it fear or worrying about their ...
(Date:8/29/2020)... (PRWEB) , ... August 29, 2020 , ... When professor ... perhaps with greater ease than most people would. Rather than become melancholic, however, he ... deep advice on achieving one’s dreams. Randy Pausch took a negative situation and turned ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... September 02, 2020 , ... U.S. Dermatology Partners is excited ... Lee will work at Bethesda Dermatopathology Lab. , Jonathan Lee, MD grew ... of California, Berkley. He went on to receive his M.D. with Honors from Harvard ...
(Date:9/1/2020)... ... September 01, 2020 , ... Neil Oberfeld of global law ... the Board of Trustees and committee chair of the Governance Committee for Mile ... nonprofit organization that fights for the education, health, and financial stability of residents ...
(Date:9/1/2020)... ... 2020 , ... September is National Ovarian Cancer Awareness Month. Ovarian cancer ... cancer of the female reproductive system. The American Cancer Society estimates that in ... will die from this disease. Throughout the month of September, Women’s Excellence aims ...
Breaking Medicine Technology: