Navigation Links
Warwick scientists uncover how 'checkpoint' proteins bind chromosomes
Date:4/20/2012

The development of more effective cancer drugs could be a step nearer thanks to the discovery, by scientists at Warwick Medical School, of how an inbuilt 'security check' operates to guarantee cells divide with the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. The process of chromosome segregation is monitored by a system called the spindle checkpoint that ensures daughter cells receive the correct number of chromosomes.

If daughter cells receive an unequal number of chromosomes, known as 'aneuploidy', this drives normal cells to become cancerous. Indeed, the cells of aggressive human tumours are frequently 'aneuploid' with many components of the spindle checkpoint being mutated or mis-expressed. Therefore, determining how the spindle checkpoint operates is vital to understanding what causes, and what can prevent, the formation of tumours.

Current Biology has published research by Professor Jonathan Millar at the University of Warwick that pinpoints the precise mechanism by which spindle checkpoint proteins bind chromosomes.

Professor Millar explained: "Components of the spindle assembly checkpoint were first discovered 22 years ago by researchers in America and yet, until now, the binding sites for these proteins on chromosomes have remained unknown. We have been able to answer this question and as a result, we are now in a much better position to design more selective and effective drugs."

Currently, one of the most frequently used anti-cancer drugs are taxanes, which prevent proper inactivation of the spindle checkpoint and result in selective death of cancer, but not normal, cells. However, this class of drug can have debilitating side effects including permanent neurological damage and hair loss side effects that could be reduced if cancer cells could be targeted more selectively.

Professor Millar was quick to point out that this is not an overnight cure: "This research is a significant advance in our understanding of how the spindle checkpoint operates but it is really just the start. More research has to be done before we can convert this into a commercial treatment for patients. But we are greatly encouraged that our research here at Warwick is leading the way in the search for more effective cancer drugs."


'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Related medicine news :

1. Warwick joins $3.4 million Anglo-Canadian quest for new weapons in war against antibiotic resistance
2. Warwick scientists discover how daughter cells receive the same number of chromosomes
3. Scientists rewrite rulebook on breast cancer in landmark global study
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists solving the mystery of human consciousness
8. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
9. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
10. Scientists study link between amyloid beta peptide levels and Alzheimers disease
11. Scientists measure how energy is spent in martial arts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... , ... March 27, 2017 , ... ... quickly sideline athletes. A type of groin injury, it occurs when the muscles ... serious, intense pain in and around the lower torso, as well as accompanying ...
(Date:3/27/2017)... ... March 27, 2017 , ... The ... supply chain professionals, will hold their first Northeast Regional AHVAP Meeting. For 2017, ... , “Increasingly, supply chain and value analysis professionals have a ‘seat at the ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... to announce the launch of a months-long rebranding effort. This includes the introduction ... “Through focus group discussions and market research, we learned that a simple, proactive ...
(Date:3/27/2017)... ... March 27, 2017 , ... Harris Communications, Inc., a leading ... bringing its latest products to the Deaf Seniors of America Conference, April 4-7 at ... to meet with knowledgeable ASL friendly staff from Harris Communications and to try out ...
(Date:3/24/2017)... ... March 24, 2017 , ... Vighter established ... same time by providing Prehospital Trauma Life Support (PHTLS) course scholarships to four ... prehospital trauma education developed in cooperation with the American College of Surgeons to ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017 On Friday, benchmark ... Composite closed the trading session up 0.19%; the Dow ... 500 was down 0.08%. US markets made broad based ... day in green. Pre-market today, Stock-Callers.com reviews these four ... (NASDAQ: WMGI), Amedica Corporation (NASDAQ: AMDA), MiMedx Group Inc. ...
(Date:3/27/2017)... Calif. , March 27, 2017  Impax Laboratories, ... has appointed Paul M. Bisaro as Impax,s ... the Company,s Board, effective March 27, 2017. Mr. Bisaro ... served as Interim President and Chief Executive Officer since ... of generic and branded pharmaceutical experience, Mr. Bisaro, 56, ...
(Date:3/27/2017)... , March 27, 2017 Arena Pharmaceuticals, Inc. ... on developing novel, small molecule drugs across multiple therapeutic areas, ... Chief Executive Officer, will present a corporate update at the ... 3:40pm ET.  The conference will take place April 4-5, 2017 ... New York , NY.  A live ...
Breaking Medicine Technology: