Navigation Links
Warwick scientists uncover how 'checkpoint' proteins bind chromosomes
Date:4/20/2012

The development of more effective cancer drugs could be a step nearer thanks to the discovery, by scientists at Warwick Medical School, of how an inbuilt 'security check' operates to guarantee cells divide with the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. The process of chromosome segregation is monitored by a system called the spindle checkpoint that ensures daughter cells receive the correct number of chromosomes.

If daughter cells receive an unequal number of chromosomes, known as 'aneuploidy', this drives normal cells to become cancerous. Indeed, the cells of aggressive human tumours are frequently 'aneuploid' with many components of the spindle checkpoint being mutated or mis-expressed. Therefore, determining how the spindle checkpoint operates is vital to understanding what causes, and what can prevent, the formation of tumours.

Current Biology has published research by Professor Jonathan Millar at the University of Warwick that pinpoints the precise mechanism by which spindle checkpoint proteins bind chromosomes.

Professor Millar explained: "Components of the spindle assembly checkpoint were first discovered 22 years ago by researchers in America and yet, until now, the binding sites for these proteins on chromosomes have remained unknown. We have been able to answer this question and as a result, we are now in a much better position to design more selective and effective drugs."

Currently, one of the most frequently used anti-cancer drugs are taxanes, which prevent proper inactivation of the spindle checkpoint and result in selective death of cancer, but not normal, cells. However, this class of drug can have debilitating side effects including permanent neurological damage and hair loss side effects that could be reduced if cancer cells could be targeted more selectively.

Professor Millar was quick to point out that this is not an overnight cure: "This research is a significant advance in our understanding of how the spindle checkpoint operates but it is really just the start. More research has to be done before we can convert this into a commercial treatment for patients. But we are greatly encouraged that our research here at Warwick is leading the way in the search for more effective cancer drugs."


'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Related medicine news :

1. Warwick joins $3.4 million Anglo-Canadian quest for new weapons in war against antibiotic resistance
2. Warwick scientists discover how daughter cells receive the same number of chromosomes
3. Scientists rewrite rulebook on breast cancer in landmark global study
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists uncover multiple faces of deadly breast cancer
7. Scientists solving the mystery of human consciousness
8. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
9. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
10. Scientists study link between amyloid beta peptide levels and Alzheimers disease
11. Scientists measure how energy is spent in martial arts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Boca Raton, FL (PRWEB) , ... January 21, 2017 , ... ... from Germany, announced it is bringing its product to the United States as part ... perfected over the last 25 years, Alcovit aims to reduce the productions of nasty ...
(Date:1/21/2017)... ... January 21, 2017 , ... Pacifica Graduate Institute’s Alumni Association ... of events for its annual meeting “Coming Home 2017,” an activity-packed weekend of ... 2017” will be held on Friday January 27 through Sunday, January 29, 2017 ...
(Date:1/21/2017)... , ... January 21, 2017 , ... ... Austin, Texas Periodontist Dr. Dan Holtzclaw in media for its creos™ line of ... surgeries performed by Dr. Holtzclaw in which he utilizes creos™ allo.gain™ bone graft ...
(Date:1/20/2017)... , ... January 20, 2017 , ... Source Vitál Apothecary, ... 100 percent pure essential oils, announced the company had a successful visit to the ... annual ECRM event gives companies that work in the nutritional, sports and health industries ...
(Date:1/20/2017)... ... January 20, 2017 , ... ATP Science, an ... lives, recently attended the January ECRM Trade Show in Hilton Head, SC, benefiting ... its large range of supplements that keep the body functioning at its peak ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... Trends - Technology, Route Of Administration, End User - Forecast to ... ... to grow at a CAGR of around 7.8% over the next ... This industry report analyzes the global markets for Advanced Drug Delivery ...
(Date:1/20/2017)...  Ethicon Endo-Surgery, Inc. announced today that ... a privately held medical device company that ... in operating rooms worldwide. The acquisition brings ... devices with Megadyne,s innovative portfolio of electrosurgical ... Ethicon,s goal to deliver the most comprehensive ...
(Date:1/20/2017)... Fla. , Jan. 20, 2017 Wells Specialty ... at 3796 Howell Branch Rd in Winter Park, ... Winter Park . Operations have been consolidated into ... Pharmacy is also pleased to announce that Chad Tomlinson ... President of the Company effective immediately. Mr. Tomlinson is a ...
Breaking Medicine Technology: