Navigation Links
Warwick scientists discover how daughter cells receive the same number of chromosomes
Date:11/1/2011

Scientists at Warwick Medical School have uncovered the molecular process of how cells are by-passing the body's inbuilt 'health checkpoint' with cells that carry unequal numbers of chromosomes that have a higher risk of developing cancer.

Studying simple yeast cells, scientists now understand the mechanism by which cells ensure their daughter cells receive the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. In healthy, dividing human cells, each of these chromosomes is duplicated and one copy passed to each of the two daughter cells. However, if this process is disturbed, daughter cells receive an unequal number of chromosomes, a state that is known to drive normal cells to become cancerous. In fact, aggressive human tumours are frequently composed of cells with an abnormal complement of chromosomes.

Professor Jonathan Millar explained: "This cell division process is monitored by the body's surveillance system known as the 'spindle checkpoint', and that is only switched off once everything within the cell is set up correctly. Amazingly, all of the elements of this process are conserved from yeast to human cells. Therefore it is extremely likely that what we have found in yeast also happens in human cells. So by preventing this process happening with drugs, you could restrict the cell's ability to develop into full blown cancer," explained Professor Millar.

Currently, one of the most frequently used classes of anti-cancer drugs are taxanes, which target the mitotic apparatus in part by preventing proper silencing of the spindle checkpoint. However, this class of drug affects healthy and cancerous cells alike and can have debilitating side effects including permanent neurological damage and hair loss.

Professor Millar explained: "Now that we have pinpointed the central elements of cell division, we are in a great position to design drugs that can be more selective and targeted about which cells they treat. But this is just the start much more research has to be done before we can convert this into a commercial treatment for patients, but we are greatly encouraged that our research here at Warwick is leading the way in the search for more effective cancer treatments with fewer side effects."


'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Related medicine news :

1. NIH scientists discover link among spectrum of childhood diseases
2. Scientists Identify Gene Linked to Cold Sores
3. Scientists prove regular aspirin intake halves cancer risk
4. Scientists make strides toward drug therapy for inherited kidney disease
5. SMU scientists to lead water quality study at UN refugee camps
6. How hemp got high: Canadian scientists map the cannabis genome
7. UGA scientists team up to define first-ever sequence of biologically important carbohydrate
8. Scientists in Singapore and Europe to collaborate
9. Scientists Spot New Clues to HIV-Linked Dementia
10. Scientists Engineer Mice That Have Autism
11. Raw Sewage a New Frontier for Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
Breaking Medicine Technology: