Navigation Links
Warwick scientists discover how daughter cells receive the same number of chromosomes
Date:11/1/2011

Scientists at Warwick Medical School have uncovered the molecular process of how cells are by-passing the body's inbuilt 'health checkpoint' with cells that carry unequal numbers of chromosomes that have a higher risk of developing cancer.

Studying simple yeast cells, scientists now understand the mechanism by which cells ensure their daughter cells receive the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. In healthy, dividing human cells, each of these chromosomes is duplicated and one copy passed to each of the two daughter cells. However, if this process is disturbed, daughter cells receive an unequal number of chromosomes, a state that is known to drive normal cells to become cancerous. In fact, aggressive human tumours are frequently composed of cells with an abnormal complement of chromosomes.

Professor Jonathan Millar explained: "This cell division process is monitored by the body's surveillance system known as the 'spindle checkpoint', and that is only switched off once everything within the cell is set up correctly. Amazingly, all of the elements of this process are conserved from yeast to human cells. Therefore it is extremely likely that what we have found in yeast also happens in human cells. So by preventing this process happening with drugs, you could restrict the cell's ability to develop into full blown cancer," explained Professor Millar.

Currently, one of the most frequently used classes of anti-cancer drugs are taxanes, which target the mitotic apparatus in part by preventing proper silencing of the spindle checkpoint. However, this class of drug affects healthy and cancerous cells alike and can have debilitating side effects including permanent neurological damage and hair loss.

Professor Millar explained: "Now that we have pinpointed the central elements of cell division, we are in a great position to design drugs that can be more selective and targeted about which cells they treat. But this is just the start much more research has to be done before we can convert this into a commercial treatment for patients, but we are greatly encouraged that our research here at Warwick is leading the way in the search for more effective cancer treatments with fewer side effects."


'/>"/>

Contact: Kate Cox
kate.cox@warwick.ac.uk
University of Warwick
Source:Eurekalert

Related medicine news :

1. NIH scientists discover link among spectrum of childhood diseases
2. Scientists Identify Gene Linked to Cold Sores
3. Scientists prove regular aspirin intake halves cancer risk
4. Scientists make strides toward drug therapy for inherited kidney disease
5. SMU scientists to lead water quality study at UN refugee camps
6. How hemp got high: Canadian scientists map the cannabis genome
7. UGA scientists team up to define first-ever sequence of biologically important carbohydrate
8. Scientists in Singapore and Europe to collaborate
9. Scientists Spot New Clues to HIV-Linked Dementia
10. Scientists Engineer Mice That Have Autism
11. Raw Sewage a New Frontier for Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
(Date:10/12/2017)... ANGELES (PRWEB) , ... October 12, 2017 , ... ... Parsa Mohebi Hair Restoration, has recently contributed a medical article to the newly ... on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West Pharmaceutical ... innovative solutions for injectable drug administration, today announced that ... market opens on Thursday, October 26, 2017, and will ... and business expectations at 9:00 a.m. Eastern Time. To ... 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
Breaking Medicine Technology: