Navigation Links
Wake-up call for more research into cell metabolism

More scientific research into the metabolism of stromal support cells and immune cells and the role of the metabolism of these cell types in the development of diseases could open new therapeutic avenues for diabetes, inflammatory conditions and cancer. That was the conclusion of a review article by scientists from VIB and KU Leuven in the leading journal Nature.

Prof. Peter Carmeliet: "Consider the review article a sort of wake-up call. The metabolism of cancer cells has been examined in minute detail for decades now in order to facilitate new oncology treatments, whilst the metabolic research into other important cells such as the stromal and immune cells has not received the scientific attention that it deserves. Metabolic studies into these cells could provide new targets for the treatment of, for example, inflammatory diseases and diabetes."

Cell metabolism

Stromal cells are the support cells of the body. One important type of support cell is the endothelial cell, which lines the inner wall of blood vessels. Blood vessels transport oxygen and nutrients to cells. Immune cells attack harmful bacteria and viruses in order to remove them from the body. Each type of cell requires different types of "food" in order to convert this into the energy and nutrients required to allow the cells to do their work. This is called cell metabolism. We now know that in the case of cancer, diabetes and inflammatory diseases the supply and processing of this "food" to endothelial cells and other support cells is abnormal. This allows endothelial cells to form new blood vessels (also called angiogenesis) in an excessive manner and causes tumors to grow aggressively due to the fact that the supply of cell nutrients is cranked up.

In the interests of the patients

Cancer research of the past 15 to 20 years has focused almost exclusively on the metabolism of cancer cells. However, the focus on cancer cells has placed efforts to study other important cells such as endothelial cells and immune cells on the back burner. This is a shortcoming according to Peter Carmeliet, Bart Ghesquire, Brian W. Wong and Anna Kuchnio in their review article that will be published in Nature on 10 July. All the evidence seems to indicate that thorough research into the cell metabolism of stromal cells, endothelial cells and immune cells could result in new treatment options not only for cancer, but also for diabetes and inflammatory diseases. This will also be necessary to improve the current cancer treatments. Indeed, angiogenesis inhibitors are being used to combat cancer, but their success is limited by the fact that cancer patients become resistant to these drugs. Strategies that will paralyze the blood vessels by taking away their energy and building blocks appear very promising. With their ardent plea in Nature they hope that in the interests of the patients the scientific focus over the coming years will shift to this sub-section of medical and pharmacological research.


Contact: Peter Carmeleit
VIB (the Flanders Institute for Biotechnology)

Related medicine news :

1. Liver fat gets a wake-up call that maintains blood sugar levels
2. Wake-Up Call: Medical Malpractice Attorneys at Console & Hollawell Express Concern After Surgeon Gives Hepatitis B to Patients
3. Wake-Up Cigarette May Raise Risk for Lung, Mouth Cancers
4. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
5. NIH awards $20 million over 5 years to train next generation of global health researchers
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
8. Sexually abused boys at risk for more unsafe sex: UBC research
9. Researchers Find Gene Mutations That May Be a Key to Autism
10. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
11. Researchers find evidence of banned antibiotics in poultry products
Post Your Comments:
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... According to ... a recent study has shown that women who successfully lose weight with a bariatric ... the United States each year. The article notes that anywhere from 40 to 50 ...
(Date:10/13/2015)... ... 13, 2015 , ... Symposium Chairman, Dr. Rod J. Rohrich is pleased to ... be held March 2nd and 3rd, 2016. The annual meeting, along with the ... physicians from around the world. , Key topics at this year's event will include ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... unique private messaging application, announced today a significant contract that will provide its ... Independence plans to build on the growing success of its Relay program, IBX ...
(Date:10/13/2015)... ... October 13, 2015 , ... NavaFit Inc. today announced the launch of ... train with, participate in local fitness & sporting events, and stay motivated. ... high medical costs drive us to get more serious about fitness and wellness, individuals ...
(Date:10/13/2015)... MA (PRWEB) , ... October 13, 2015 , ... Protein ... of the body, including muscle, bone, and blood. But how much protein does the ... complicated than it might seem, according to the October 2015 issue of Harvard ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...  A minimally-invasive treatment just became available to men ... more than 10 years of clinical trials, the Food ... of High Intensity Focused Ultrasound (HIFU), a procedure that ... tissue and minimizing chances for erectile and urinary dysfunction ... a pioneering Miami urologist who ...
(Date:10/13/2015)... ALEXANDRIA, Va. , Oct. 13, 2015 /PRNewswire-USNewswire/ ... Pharmacists Association,s (NCPA) Digest , sponsored by ... to prescription medication and more diversified pharmacy revenue ... independent community pharmacies. NCPA Digest ... to patients and particularly those in underserved inner ...
(Date:10/13/2015)... , Oct. 13, 2015  Human Longevity, Inc. ... practice of medicine, announced today the launch of the ... project that has the potential to transform healthcare. The ... Diego, CA , at HLI,s headquarters facility. More ... in other US and International cities. ...
Breaking Medicine Technology: