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Wake Forest Baptist research goes global with genetic center in India
Date:11/7/2012

hey have found that genetic variation within the FADS cluster has undergone intense natural selection and thereby led to different frequencies in the differing populations. Given these observations, the team is performing ongoing research to understand whether the dramatic increase in dietary omega-6 PUFAs found in the modern "western" diet harms certain populations more than others.

Chilton said he envisions a day when malnutrition could be optimally addressed by knowing how different populations utilize dietary components such as PUFAs. "It may be that one malnourished population requires one set of nutrients and another a different set of nutrients," he said.

Long-chain PUFAs such as docosahexaenoic acid (DHA) and arachidonic acid (AA), are vital for brain and eye development. Specifically, normal visual and cognitive development is dependent on an adequate supply of DHA and AA in synapses and photoreceptors. Additionally, said Chilton, a lack of LCPUFAs or an imbalance between omega 3 and omega 6 fatty acids has been associated with a number of behavioral abnormalities, as well as neurological and psychiatric disorders in both children and adults, particularly attention deficit hyperactivity (ADHD) and autism spectrum disorders, as well as unipolar and bipolar disorders.

This new effort is being supported with a two-year, $200,000 grant from The John E. Fogarty International Center for Advanced Study in the Health Sciences, part of The National Institutes of Health. The center supports basic, clinical and applied research and training for U.S. and foreign investigators working in the developing world. Since its formation more than 40 years ago, Fogarty has served as a bridge between NIH and the greater global health community-facilitating exchanges among investigators, providing training opportunities and supporting promising research initiatives in developing countries. Over four decades, about 5,000 scientists worldwide have received significa
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Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center
Source:Eurekalert

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