Navigation Links
Wake Forest Baptist research goes global with genetic center in India
Date:11/7/2012

WINSTON-SALEM, N.C. Nov. 7, 2012 World-renowned scientists are taking what they've learned from their multicenter research collaboration studying the health impact of fatty acids on diverse populations to set up a genetics center in India.

Wake Forest Baptist Medical Center researchers Floyd H. "Ski" Chilton, Ph.D., and Avinash K. "Avi" Shetty, M.D., are studying genetic differences in populations related to how they convert certain dietary fats known as polyunsaturated fatty acids (PUFAs).

"Given that one third of all severely malnourished children are in India, it is vital to understand the distribution of gene variants that impact long-chain PUFA synthesis in this country," Chilton said. "We're particularly interested in PUFAs because they are so critical for brain and immune development early in life."

With new grant funding from the National Institutes of Health, they will take their research to the coastal city of Mangalore in the state of Karnataka in Southern India to study its diverse populations and their genetic capacity to make PUFAs that are critical for brain, eye and immune system development.

The collaboration brings together Wake Forest Baptist, the Johns Hopkins School of Medicine and the NITTE University/K.S. Hegde Medical Academy/AB Shetty Memorial Institute of Dental Sciences in Mangalore. Chilton, a professor of physiology and pharmacology and director of the Center for Botanical Lipids and Inflammatory Disease Prevention at Wake Forest Baptist, and Shetty, a professor of pediatrics, have a long collaborative history with Rasika S. Mathias, ScD., and Kathleen Barnes, Ph.D., of Johns Hopkins.

The researchers have published numerous papers over the last several years highlighting how variations within a set of genes, known as the FADS gene cluster on chromosome 11, impact PUFA metabolism in African and European ancestry populations as well as other populations around the world. Specifically, they have found that genetic variation within the FADS cluster has undergone intense natural selection and thereby led to different frequencies in the differing populations. Given these observations, the team is performing ongoing research to understand whether the dramatic increase in dietary omega-6 PUFAs found in the modern "western" diet harms certain populations more than others.

Chilton said he envisions a day when malnutrition could be optimally addressed by knowing how different populations utilize dietary components such as PUFAs. "It may be that one malnourished population requires one set of nutrients and another a different set of nutrients," he said.

Long-chain PUFAs such as docosahexaenoic acid (DHA) and arachidonic acid (AA), are vital for brain and eye development. Specifically, normal visual and cognitive development is dependent on an adequate supply of DHA and AA in synapses and photoreceptors. Additionally, said Chilton, a lack of LCPUFAs or an imbalance between omega 3 and omega 6 fatty acids has been associated with a number of behavioral abnormalities, as well as neurological and psychiatric disorders in both children and adults, particularly attention deficit hyperactivity (ADHD) and autism spectrum disorders, as well as unipolar and bipolar disorders.

This new effort is being supported with a two-year, $200,000 grant from The John E. Fogarty International Center for Advanced Study in the Health Sciences, part of The National Institutes of Health. The center supports basic, clinical and applied research and training for U.S. and foreign investigators working in the developing world. Since its formation more than 40 years ago, Fogarty has served as a bridge between NIH and the greater global health community-facilitating exchanges among investigators, providing training opportunities and supporting promising research initiatives in developing countries. Over four decades, about 5,000 scientists worldwide have received significant research training through Fogarty funding programs. The funding will be used to set up training mechanisms for investigators and Ph.D. candidates from the three partnering institutions, which are all making in-kind contributions of staff, labs and equipment. The long-term objective, said Mathias, is to create the technical and intellectual infrastructure to carry out a larger project to analyze DNA and circulating fatty acids in major population centers in India.

"This is the first step to help us create a fertile, local academic environment and a proven infrastructure needed to better understand how diverse Indian populations synthesize fats that are critical for brain and eye development," Chilton said. "Our ultimate hope and dream is to one day create therapeutic foods based on genetic backgrounds of different populations to treat malnutrition."


'/>"/>

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Wake Forest Baptist research provides clue to unexplained excited delirium deaths
2. Wake Forest Baptist study suggests Tasers dont cause cardiac complications
3. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
4. NIH awards $20 million over 5 years to train next generation of global health researchers
5. Researchers develop a new cell and animal model of inflammatory breast cancer
6. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
7. Sexually abused boys at risk for more unsafe sex: UBC research
8. Researchers Find Gene Mutations That May Be a Key to Autism
9. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
10. Researchers find evidence of banned antibiotics in poultry products
11. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Raton, FL (PRWEB) , ... March 23, 2017 ... ... of dietary supplements that help improve all aspects of people’s health and nutrition, ... website for nutritional products. , Natural Subsistence develops nutritional supplements that help ...
(Date:3/23/2017)... El Segundo, CA (PRWEB) , ... March 23, ... ... Verisys FACIS Monthly Monitoring Healthcare products at competitive pricing. ... primary source sanctions, Exclusions, Debarments, License restrictions and Disciplinary actions. , “We are ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... non-steroidal skincare products, was awarded as winners of American Dreams & Good Housekeeping ... was hosted jointly by HSN and Good Housekeeping. , Steven Wang, MD ...
(Date:3/23/2017)... ... 23, 2017 , ... The Boulevard is honored to host Shriners and Masons ... be located in the Main West Entrance of The Boulevard (in front of JCPenney). ... is necessary and each child with a parent or guardian will be photographed for ...
(Date:3/23/2017)... ... ... “Beyond and Back”: a true-life testimony of tragedy and the miraculous power ... Rose, a wife, mother and grandmother committed to sharing her many spiritual adventures which ... new book presents actual events in the life of her family, which validate her ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...  The U.S. Food and Drug Administration today granted ... adults and pediatric patients 12 years and older with ... not received prior chemotherapy. This is the first FDA-approved ... skin cancer. "While skin cancer is one ... form called Merkel cell cancer have not had an ...
(Date:3/23/2017)... British Columbia , March 23, 2017  Sophiris ... or "Sophiris"), a clinical late-stage biopharmaceutical company developing topsalysin ... that data from its successful Phase 2a study of ... for localized prostate cancer, will be presented as a ... Annual European Association of Urology in ...
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... ... therapy devices market to grow at a CAGR of 10.16% during ... Devices Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
Breaking Medicine Technology: