Navigation Links
Wake Forest Baptist finds success with novel lung cancer treatment

WINSTON-SALEM, N.C. May 8, 2014 An old idea of retreating lung tumors with radiation is new again, especially with the technological advances seen in radiation oncology over the last decade.

The Comprehensive Cancer Center of Wake Forest Baptist Medical Center is one of only a handful of cancer centers that is attempting to give lung cancer patients out of treatment options a chance to keep the cancer at bay. For these patients, hope lies in a second course of treatment repeat radiation. Two complementary papers published back-to-back recently in the journal Radiotherapy and Oncology and the Journal of Thoracic Oncology outline the treatment success at Wake Forest Baptist.

"One of the toughest challenges of lung cancer is what to do for patients when the cancer comes back in an area that's been treated previously with radiation treatment," said James J. Urbanic, M.D., lead author of the studies and a radiation oncologist at Wake Forest Baptist. "With some of the technological advances in radiation treatments that have occurred in the last five to 10 years, we're beginning to re-look at the issue and ask can we target the radiation precisely enough and with a high enough dose to knock the cancer back?"

Urbanic said the overall findings of the study suggest that there are some patients with recurrent lung cancers who can be treated with another definitive course of radiation therapy and still have a chance at a cure. "At many cancer treatment centers, these patients only get chemotherapy and have no chance at definitive treatment. The goal of treatment is solely to prevent or delay symptoms from developing and they are seen as incurable," he said. "But with re-irradiation, our study shows that maybe we can give a curative intent treatment that we couldn't do in the past. It's a layer of hope for some patients that they never had before."

For this study, the researchers looked back at 11 years of clinical data. Eighty-six patients were identified who received at least two courses of thoracic radiotherapy. Of that number, 33 were treated with repeat thoracic radiotherapy using stereotactic body radiation therapy (SBRT) or accelerated hypofractionated radiotherapy (AHRT), as a component of their treatment. The median age was 66 and the majority of patients (88 percent) were treated for primary lung cancer. Average tumor size at retreatment was 2.5 cm. Prior lung resections had been completed in 24 percent of patients.

Urbanic said the typical patient is an older man or woman who got treated with either chemotherapy and radiation or radiation alone for a lung cancer that couldn't be surgically removed. They've returned for a checkup and feel well, but a CT scan shows that the cancer has returned in the area previously treated. If the cancer is just in one spot, the patients get retreated with 10 radiation treatments done with the SBRT technique which is tightly targeted to just the tumor and minimizes the dose to the surrounding normal tissue.

"Wake Forest Baptist has been developing expertise in doing this," Urbanic said. "We're finding that there are patients who are alive years later. We have seen relatively modest toxicity and a good ability to try and control the disease upwards of 70 percent of the time."

But there is a higher risk of injury involved when someone is radiated a second time which is why other cancer treatment center programs might be reluctant to adopt the practice, he said.

"This is a fairly niche effort in lung cancer care, and we'd like to see a national level clinical trial at some point," he said. "The technology has gotten to the point where I think it's going to allow radiation oncologists to reassess their ability so that maybe they can take risks they weren't willing to take before. Eventually, this practice will become more widespread."


Contact: Bonnie Davis
Wake Forest Baptist Medical Center

Related medicine news :

1. Wake Forest Baptist research provides clue to unexplained excited delirium deaths
2. Wake Forest Baptist study suggests Tasers dont cause cardiac complications
3. Wake Forest Baptist research goes global with genetic center in India
4. Is housework a health hazard? Sheet-Fitting palsy described by wake forest baptist physicians
5. Smaller radiation fields can spare brain when treating tumors, Wake Forest Baptist research finds
6. Measuring the consequence of forest fires on public health
7. Nashville Periodontal Group Is Expanding Their Sedation Dentistry To Include Patients In Forest Hills, TN Needing Dental Anxiety Relief
8. Wake Forest Baptist research provides clues to alcohol addiction vulnerability
9. Wake Forest Herbfest Sponsors America In Bloom Competition
10. New Supplement Amaçari is Made from the Amazon Rainforest’s Most Potent Known Superfruit
11. The Republic of Tea Introduces 2013 First Flush Darjeeling Full-Leaf Organic, Rainforest Alliance Certified™ Tea
Post Your Comments:
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... AccentCare, a leader in post-acute health care, have expanded their existing home health ... Home Health. , AccentCare has been operating a joint venture home health company ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology: