Navigation Links
WaferGen's SmartChip(TM) Real-Time PCR System to Begin Alpha Testing at University of Pittsburgh Medical School
Date:6/30/2008

Company Sends Final Alpha System and Key Oncology Gene Panel Assays to

Collaborators at University of Pittsburgh Medical School

FREMONT, Calif., June 30 /PRNewswire-FirstCall/ -- WaferGen Biosystems, Inc. (OTC Bulletin Board: WGBS), a leading developer of state-of-the-art gene expression, genotyping, cell biology and stem cell research systems, today announced that it has shipped the alpha version of its SmartChip(TM) Real-Time PCR System, as well as proprietary oncology gene panel assays to be used with the system, to the University of Pittsburgh Medical School. This milestone will allow researchers at the University of Pittsburgh Medical School to initiate the alpha testing program for the system and panels as part of the group's alpha testing and research collaboration with WaferGen. The SmartChip Real-Time PCR System is designed as the first whole genome, high throughput gene expression real-time polymerase chain reaction (PCR) platform and promises to deliver significant speed and cost advantages to researchers in the gene expression and genotyping markets.

The SmartChip Real-Time PCR System has the capacity to conduct 30,000 assays on a single chip. Comparatively, today's standard real-time PCR technologies are only able to run 384 assays on a single plate. Additionally, each of the system's wells is designed to support a real-time PCR reaction of 100 nanoliters. This represents a 1,000 fold decrease in the amount of reagent and sample required by today's standard real-time PCR technologies. The result is the ability to conduct gene expression research at a fraction of the time and cost associated with current technologies.

Under terms of WaferGen's collaboration with the University of Pittsburgh Medical School, researchers will leverage the high-throughput real-time PCR capabilities of WaferGen's SmartChip Real-Time PCR System to support their identification of therapeutically-relevant biomarkers in the areas of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. This research may lead to the discovery of specific genes responsible for causing these diseases and conditions. In turn, this critical genetic information may ultimately provide physicians with new tools for determining accurate disease prognosis in patients, while also potentially providing drug developers with information necessary for the creation of targeted therapeutics for patients with COPD, IPF and lung cancer. WaferGen expects the alpha testing program will demonstrate significant cost and speed advantages for the SmartChip Real-Time PCR System as compared to other commercialized platforms. These experiments will be overseen by Steven D. Shapiro, M.D., Jack D. Myers Professor and Chairman of the Department of Medicine at University of Pittsburgh and Naftali Kaminski, M.D., Director of the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease.

"The shipment of the alpha version of the SmartChip Real-Time PCR System to the University of Pittsburgh Medical School is a significant milestone for WaferGen as we work to rapidly bring this innovative product to the market," said Alnoor Shivji, WaferGen's chairman and chief executive officer. "We are eager to follow the progress of Dr. Shapiro and his research team as they advance the SmartChip Real-Time PCR System through alpha testing. The feedback that they will be able to provide WaferGen will be invaluable as we continue to pursue our mission of providing researchers around the world with access to the SmartChip Real-Time PCR System."

Dr. Shapiro is a world-renowned expert in identifying and understanding the underlying biological contributors to pulmonary diseases such as COPD, IPF, and lung cancer. His laboratory has played a leading role in guiding the path of cutting-edge COPD research including key discoveries related to the biological and pathological function of proteinases. With the goal of uncovering novel and effective pulmonary disease therapeutics, Dr. Shapiro and his team employ a multidisciplinary research approach which the SmartChip Real-Time PCR System is expected to strengthen.

WaferGen is presently continuing its work on the development of additional proprietary assays for the SmartChip Real-Time PCR System, including those focused in the area of toxicology. At the same time, the company is also developing an enhanced version of the system that will enable users to conduct 100,000 assays on a single chip. This will provide the opportunity for researchers to use one chip to conduct whole genome gene expression in triplicate.

About the SmartChip Real-Time PCR System

The SmartChip Real-Time PCR System(TM) is designed as the first whole genome, high-throughput gene expression real-time PCR platform and promises to deliver significant speed and cost advantages to researchers in the gene expression and genotyping markets. It is estimated that the genetic analysis market alone (comprised of gene expression and genotyping analysis) had approximately $2.4 billion in worldwide revenues in 2006 ($1.74 billion for gene expression and $650 million for genotyping). Total global revenue for this market is estimated to reach approximately $5.0 billion by 2012.

WaferGen believes the SmartChip Real-Time PCR System will be the first platform to combine the high-throughput capability and cost efficiencies of existing microarrays, with the sensitivity and accuracy of real-time PCR. Specifically, the SmartChip Real-Time PCR System's high density, rapid cycling configuration is expected to provide industry-leading throughput levels, while offering discovery and validation capabilities in a single step. The result will be the ability to conduct gene expression research at a fraction of the time and cost currently produced by existing instrument systems. For example, the company anticipates that whole genome assay time may be significantly reduced with the SmartChip Real-Time PCR System as compared to several days or months with microarrays or real-time PCR, respectively. This decrease in research time has broad economic implications across the drug development industry, particularly for pharmaceutical companies seeking avenues for reducing time to market for its therapeutics. Further, the company believes such throughput will dramatically impact the cost of such assays.

Beyond the significant time and cost advantages, the simplicity of the SmartChip Real-Time PCR System is unparalleled. The system will provide a number of key ease-of-use features including content-ready, high-density chips containing 30,000 - 100,000 nano-wells with gene panels optimized for cancer, toxicology and whole genome. The user-friendly SmartChip Real-Time PCR System will be preloaded with some of the reaction components. At the same time, the system will only require a very small sample size as compared to other technologies and platforms and will offer real-time detection and sophisticated read-out options while assuring detection sensitivity and temperature uniformity across chips.

About WaferGen

WaferGen Biosystems Inc. is a leader in the development, manufacture and sale of state-of-the-art systems for gene expression, genotyping, cell biology and stem cell research for the life science and pharmaceutical industries. The company is actively developing its SmartChip(TM) product for the gene expression and genotyping markets. SmartChip(TM) is being developed as the first whole genome, high throughput gene expression real-time polymerase chain reaction (PCR) platform and promises to deliver significant speed and cost advantages to researchers in the gene expression and genotyping markets. WaferGen currently markets its SmartSlide(TM) family of products to companies and organizations involved in stem cell and cell biology research. SmartSlide(TM), which was launched in 2006, represents the first fluidics integrated micro-incubators enabling cell biology and stem cell research. Representative SmartSlide(TM) customers include Harvard University, Mayo Clinic, California Institute of Technology (CalTech), Abbott Labs, and the National Institutes of Health (NIH).

To learn more about WaferGen, please visit the company's web site at http://www.wafergen.com.

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995

This press release contains certain "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Such statements include statements relating to the expected benefits of the company's SmartChip(TM) Real-Time PCR System to researchers at the University of Pittsburgh Medical School and other researchers, the ability of the company to bring the SmartChip(TM) Real-Time PCR System to market, and other statements that are not historical facts, including statements which may be preceded by the words "intends," "may," "will," "plans," "expects," "anticipates," "projects," "predicts," "estimates," "aims," "believes," "hopes," "potential" or similar words. For such statements, the company claims the protection of the Private Securities Litigation Reform Act of 1995.

Forward-looking statements are not guarantees of future performance, are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the control of the company. Actual results may differ materially from the expectations contained in the forward-looking statements. Factors that may cause such differences include the risks that: (i) the company may be unsuccessful in commercially developing its products or in achieving market acceptance of new and relatively unproven technologies; (ii) the company will need to raise additional capital to meet its business requirements in the future and the company may not be able to do so on reasonable terms or at all; (iii) the company's proprietary intellectual property rights may not adequately protect its products and technologies; and (iv) the company expects intense competition in its target markets, including from companies that have much greater resources than the company, and there can be no assurance that the company will be able to compete effectively. More detailed information about the company and the risk factors that may affect the realization of forward-looking statements is set forth in the company's filings with the Securities and Exchange Commission, including the company's Quarterly Report on Form 10-Q filed with the SEC on May 15, 2008. Investors and security holders are urged to read this document free of charge on the SEC's web site at http://www.sec.gov. The company does not undertake to publicly update or revise its forward-looking statements as a result of new information, future events or otherwise.

Contact:

Vida Communication (On behalf of WaferGen)

Stephanie Diaz (investors) Tim Brons (media)

415-675-7400 415-675-7402

sdiaz@vidacommunication.com tbrons@vidacommunication.com


'/>"/>
SOURCE WaferGen Biosystems, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. The DataTrace(R) RF System, the Latest High Performance Radio Data Logger for Real-Time, Process Data Collection, Reporting, and Analysis Is Launched
2. Cantimer, Inc. Awarded $996,000 Contract from U.S. Government to Develop Portable, Real-Time and Non-Invasive Hydration Measurement and Monitoring System for Use by Firefighters
3. Quest Diagnostics Chooses Roches Fully Automated, Real-Time HIV-1 Viral Load Monitoring Test For Its Customers in Laboratories Nationwide
4. Ekahau Offers Clear Visibility Into Real-Time Location Tracking With Ekahau Vision
5. Four Rivers Software Systems and ECRI Institute Announce New, Real-Time Interfaces to Improve Inventory Management and Patient Safety Alert and Recall Tracking
6. Mouse study: Real-time imaging device may improve surgery for congenital colon disease
7. Harris Corporation Unveils Broadcast-Style Multiviewers for Real-Time Multi- Screen Access to Medical Information
8. Colubris Partners with AeroScout to Enable Real-time Location Detection over Wireless Networks
9. PetlinQ Signs Agreement With SpeakLike for Accurate, Real-Time Translation Chat
10. Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
11. SYMX Builds on Top of New Microsoft Technologies to Offer Hospitals Real-Time Business and Patient Safety Solutions Using RFID Data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, ... M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... the most handsome men, look naturally attractive. Plastic surgery should be invisible.” He ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: