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WVU Doctor Works to Reduce Cancer Burden in Africa
Date:6/12/2009

pe in Africa -- a low-dose chemotherapy regimen for people with AIDS-related non-Hodgkin's lymphoma. The trial showed dramatic results -- a 6 percent mortality rate, compared with an expected 20 percent to 66 percent rate in the Kenyan and Ugandan populations studied.

The research team chose a low-dose chemotherapy regimen because it's vital that cancer therapies in sub-Saharan Africa be less myelotoxic -- or damaging to bone marrow -- than conventional treatment plans. Money, means and blood products may not exist in resource-challenged countries to counteract chemotherapy's potentially destructive effects on bone marrow.

Remick, senior researcher on the study published in the current issue of the Journal of Clinical Oncology, said the clinical trial represents a dozen years of work. Partners in the project are Case Western Reserve University in Ohio, Ohio State University, the Uganda Cancer Institute and Kenyatta National Hospital as well as medical schools in Uganda and Kenya.

The AIDS Malignancy Consortium will be promoting measures such as vaccination and other strategies aimed at preventing cancer as well as screening programs to encourage early diagnosis. Development of more low-dose chemotherapy trials is also on the agenda.

"The hope is that, as things will evolve, our efforts will be less about awareness and advocacy and more about action," Remick said.

This news release was issued on behalf of Newswise(TM). For more information, visit http://www.newswise.com.


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SOURCE West Virginia University Health Sciences Center
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