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WUSTL researcher gets $2.25 million grant to better understand traumatic brain injury
Date:2/22/2013

o the computer models.

"The world is going to learn about the basic physics of brain injury, but also develop approaches to prevention and therapy, through computer simulation," he says. "It's really hard to simulate the brain because it's really complicated. The necessary ingredients for good simulations are materials, the structure, how the materials are put together and data for validation. That's what we're providing."

The team also is providing the opportunity to check the simulations through image processing techniques so other researchers can take that data and validate the simulations.

Bayly says it's very difficult to study brain biomechanics without models.

"When you're moving around, your brain is suspended," he says. "The suspension of the brain in the skull is really important. We found that when you're moving your head normally, and even in mild concussions, it's probably not the impact of the brain against the skull that provides most deformation. It's probably the brain working against the suspension in side that's producing most of the deformation."

By studying chronic traumatic brain injury in football players, other researchers have found that the concentration of nerve damage or protein accumulations near blood vessels may be due to the mechanical effects of blood vessels restraining the tissues.

"This is an example where understanding mechanics can give insight into mechanism and potential therapeutic strategy," Bayly says. Bayly is working with Jerry L. Prince, PhD, the William B. Kouwenhoven Professor of Electrical and Computer Engineering, and KT Ramesh, PhD, professor of mechanical engineering, both at Johns Hopkins University; as well as Dzung Pham at the Henry M. Jackson Foundation.


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Contact: Neil Schoenherr
nschoenherr@wustl.edu
314-935-5235
Washington University in St. Louis
Source:Eurekalert

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