Navigation Links
WSU study may lead to greater understanding of human genome regulation
Date:3/4/2011

DETROITMany multi-cellular animals use sex chromosomes to determine sex. In fruit flies and in humans, this produces XX for females and XY for males. Cellular mechanisms then kick into gear to compensate the two-to-one imbalance of X-linked genes in females and males.

Victoria Meller, Ph.D., associate professor of biological sciences and resident of Huntington Woods, Mich., received $301,392 from the National Institute of General Medical Sciences of the National Institutes of Health to investigate the role of a type of RNA in the X chromosome dosage compensation of Drosophila, or fruit flies. The findings are likely to improve the understanding of gene regulation in humans, which employ similar cellular tools to regulate their complex genome.

Uncovering clues in genetic regulation in humans is instrumental in understanding a wide range of pathologies, including cancer, developmental abnormalities and some birth defects. The misregulation of large groups of genes is characteristic of these diseases.

There are significant differences in the way humans and fruit flies achieve X chromosome dosage compensation. "Humans double the expression of genes on the X chromosome, then deactivate one X chromosome in the female," Meller said. "Taking a much simpler approach, fruit flies double the X-expression from the male X chromosome and keep the female level the same."

Although these approaches differ, humans and flies both use regulatory complexes that recognize the X chromosome. These complexes bind to and alter chromatin, the structure formed by DNA and associated proteins, to change the expression of the entire chromosome. "It's somewhat of a mystery, though, how these complexes identify the X chromosome," Meller said.

Recently, Meller's lab uncovered clues that a class of non-coding RNA called RNAi plays a role in X chromosome recognition. Her current study will explore the role of RNAi, along with short DNA sequences on the X chromosome, in X chromosome recognition.

Because of the similarities of human and fruit fly X chromosome recognition, findings from Meller's lab are likely to contribute to the understanding of gene regulation in humans. "Exploring how organisms achieve overall regulation of large groups of genes is basic research," said Meller. "Flies and mammals have the same tool kit for regulating their genome, and we are looking at how they use it."

"New information on how regulation works may lead to greater understanding of how those systems sometimes fail and how future medical interventions can potentially treat these health problems," Meller said.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. White Patients Most Likely to Get Kidney Transplants: Study
2. Risk of Drug-Resistant Staph Infection in Gym Low: Study
3. Parks Add Options for Kids Exercise, Study Finds
4. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
5. Study Finds Third of Cancer Patients on Opioids Are Confused
6. Diabetes Ups Death Risk Overall, Study Shows
7. Men in low income neighborhoods drink more than women: Study
8. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
9. 6 out of 10 male drug-addicts abuse their partners, a study says
10. Study finds MRSA danger in gyms may be exaggerated
11. 6-month drug regimen cuts HIV risk for breastfeeding infants, NIH study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in ... ways they remain in the eye of the beholder, according to experts who offered ... The American Journal of Managed Care. For the full issue, click here . ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
Breaking Medicine Technology: