Navigation Links
WSU study may lead to greater understanding of human genome regulation
Date:3/4/2011

DETROITMany multi-cellular animals use sex chromosomes to determine sex. In fruit flies and in humans, this produces XX for females and XY for males. Cellular mechanisms then kick into gear to compensate the two-to-one imbalance of X-linked genes in females and males.

Victoria Meller, Ph.D., associate professor of biological sciences and resident of Huntington Woods, Mich., received $301,392 from the National Institute of General Medical Sciences of the National Institutes of Health to investigate the role of a type of RNA in the X chromosome dosage compensation of Drosophila, or fruit flies. The findings are likely to improve the understanding of gene regulation in humans, which employ similar cellular tools to regulate their complex genome.

Uncovering clues in genetic regulation in humans is instrumental in understanding a wide range of pathologies, including cancer, developmental abnormalities and some birth defects. The misregulation of large groups of genes is characteristic of these diseases.

There are significant differences in the way humans and fruit flies achieve X chromosome dosage compensation. "Humans double the expression of genes on the X chromosome, then deactivate one X chromosome in the female," Meller said. "Taking a much simpler approach, fruit flies double the X-expression from the male X chromosome and keep the female level the same."

Although these approaches differ, humans and flies both use regulatory complexes that recognize the X chromosome. These complexes bind to and alter chromatin, the structure formed by DNA and associated proteins, to change the expression of the entire chromosome. "It's somewhat of a mystery, though, how these complexes identify the X chromosome," Meller said.

Recently, Meller's lab uncovered clues that a class of non-coding RNA called RNAi plays a role in X chromosome recognition. Her current study will explore the role of RNAi, along with short DNA sequences on the X chromosome, in X chromosome recognition.

Because of the similarities of human and fruit fly X chromosome recognition, findings from Meller's lab are likely to contribute to the understanding of gene regulation in humans. "Exploring how organisms achieve overall regulation of large groups of genes is basic research," said Meller. "Flies and mammals have the same tool kit for regulating their genome, and we are looking at how they use it."

"New information on how regulation works may lead to greater understanding of how those systems sometimes fail and how future medical interventions can potentially treat these health problems," Meller said.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. White Patients Most Likely to Get Kidney Transplants: Study
2. Risk of Drug-Resistant Staph Infection in Gym Low: Study
3. Parks Add Options for Kids Exercise, Study Finds
4. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
5. Study Finds Third of Cancer Patients on Opioids Are Confused
6. Diabetes Ups Death Risk Overall, Study Shows
7. Men in low income neighborhoods drink more than women: Study
8. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
9. 6 out of 10 male drug-addicts abuse their partners, a study says
10. Study finds MRSA danger in gyms may be exaggerated
11. 6-month drug regimen cuts HIV risk for breastfeeding infants, NIH study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... , ... The American College of Medical Informatics (ACMI) will present the 2017 ... Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is ... pioneer in the field of medical informatics, this prestigious award is presented to an ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader ... a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were ... 11, 2017. , The annual award competition recognizes editorial and design excellence across a ...
(Date:10/12/2017)... ... 12, 2017 , ... On Saturday, October 21, the Health & Wellness Center ... to raise money for the American Heart Association Heart Walk. Teams of up to ... together to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... MIAMI , Sept. 27, 2017  Commended for their ... recent notable awards. Ranked as number one in the South ... ninth time in Inc. 5000 yearly list, the national specialty ... CEO, Armando Bardisa will soon be honored by ... Set to receive his award ...
Breaking Medicine Technology: