Navigation Links
WSU study may lead to greater understanding of human genome regulation
Date:3/4/2011

DETROITMany multi-cellular animals use sex chromosomes to determine sex. In fruit flies and in humans, this produces XX for females and XY for males. Cellular mechanisms then kick into gear to compensate the two-to-one imbalance of X-linked genes in females and males.

Victoria Meller, Ph.D., associate professor of biological sciences and resident of Huntington Woods, Mich., received $301,392 from the National Institute of General Medical Sciences of the National Institutes of Health to investigate the role of a type of RNA in the X chromosome dosage compensation of Drosophila, or fruit flies. The findings are likely to improve the understanding of gene regulation in humans, which employ similar cellular tools to regulate their complex genome.

Uncovering clues in genetic regulation in humans is instrumental in understanding a wide range of pathologies, including cancer, developmental abnormalities and some birth defects. The misregulation of large groups of genes is characteristic of these diseases.

There are significant differences in the way humans and fruit flies achieve X chromosome dosage compensation. "Humans double the expression of genes on the X chromosome, then deactivate one X chromosome in the female," Meller said. "Taking a much simpler approach, fruit flies double the X-expression from the male X chromosome and keep the female level the same."

Although these approaches differ, humans and flies both use regulatory complexes that recognize the X chromosome. These complexes bind to and alter chromatin, the structure formed by DNA and associated proteins, to change the expression of the entire chromosome. "It's somewhat of a mystery, though, how these complexes identify the X chromosome," Meller said.

Recently, Meller's lab uncovered clues that a class of non-coding RNA called RNAi plays a role in X chromosome recognition. Her current study will explore the role of RNAi, along with short DNA sequences on the X chromosome, in X chromosome recognition.

Because of the similarities of human and fruit fly X chromosome recognition, findings from Meller's lab are likely to contribute to the understanding of gene regulation in humans. "Exploring how organisms achieve overall regulation of large groups of genes is basic research," said Meller. "Flies and mammals have the same tool kit for regulating their genome, and we are looking at how they use it."

"New information on how regulation works may lead to greater understanding of how those systems sometimes fail and how future medical interventions can potentially treat these health problems," Meller said.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related medicine news :

1. White Patients Most Likely to Get Kidney Transplants: Study
2. Risk of Drug-Resistant Staph Infection in Gym Low: Study
3. Parks Add Options for Kids Exercise, Study Finds
4. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
5. Study Finds Third of Cancer Patients on Opioids Are Confused
6. Diabetes Ups Death Risk Overall, Study Shows
7. Men in low income neighborhoods drink more than women: Study
8. Latest findings of Dartmouth HIV/AIDS study could turn treatment on its head
9. 6 out of 10 male drug-addicts abuse their partners, a study says
10. Study finds MRSA danger in gyms may be exaggerated
11. 6-month drug regimen cuts HIV risk for breastfeeding infants, NIH study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2017)... ... January 22, 2017 , ... Zifam Pinnacle, an Australian company dedicated ... met with big-name retail buyers at the January ECRM Trade Show in Hilton Head, ... the utmost safety standards in all of its creations to help create a more ...
(Date:1/21/2017)... ... ... Salveo for life, a company that distributes an effervescent lime-flavored drink called ... part of its presence to expand its market reach. , Using a formula developed ... nasty toxins as a result of drinking alcohol, eliminating those toxins quickly, whilst supporting ...
(Date:1/21/2017)... ... January 21, 2017 , ... ... Dianne Travis-Teague, the electrifying line-up of events for its annual meeting “Coming Home ... and community. “Coming Home 2017” will be held on Friday January 27 ...
(Date:1/21/2017)... ... January 21, 2017 , ... The Nobel ... Dan Holtzclaw in media for its creos™ line of bone regenerative products. ... Holtzclaw in which he utilizes creos™ allo.gain™ bone graft for a variety of ...
(Date:1/20/2017)... ... 20, 2017 , ... Source Vitál Apothecary, a skin and body care company ... the company had a successful visit to the 2017 ECRM Diet, Vitamin & Sports ... work in the nutritional, sports and health industries a chance to meet in private ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017 Many patients don,t realize that they ... a pharmacy just a few blocks away charges only ... problem Medicationdiscountcard.com has created a price comparison ... much their medication will cost at most nearby pharmacies. ... Medicationdiscountcard.com takes all of the ...
(Date:1/19/2017)...  Abaxis, Inc. (NasdaqGS: ABAX ), a ... consumables for the medical and veterinary markets worldwide, has ... for the third quarter fiscal year 2017, ended December ... ET on Thursday, January 26, 2017.  The Company will ... 2017 after the market closes on Thursday, January 26, ...
(Date:1/19/2017)... 19, 2017   Science Exchange , the leading ... that the first five replication studies from the ... published in eLife today. Despite intense scrutiny around ... practical evaluation of reproducibility rates that may identify ... other assessments of reproducibility, the results of this ...
Breaking Medicine Technology: