Navigation Links
WSU researchers discover mechanism leading from trichomoniasis to prostate cancer
Date:8/29/2012

PULLMAN, Wash.Researchers have identified a way in which men can develop prostate cancer after contracting trichomoniasis, a curable but often overlooked sexually transmitted disease.

Previous studies have teased out a casual, epidemiological correlation between the two diseases, but this latest study suggests a more tangible biological mechanism.

John Alderete, a professor at Washington State University's School of Molecular Biosciences, says the trichomoniasis parasite activates a suite of proteins, the last of which makes sure the proteins stay active.

"It's like switching a light switch on," he says. "Then, if you don't control the brightness of that light, you can go blind. That's the problem."

Alderete and colleagues at WSU and Washington University in St. Louis report their findings in the recent PLoS Pathogens.

Caused by a protozoan parasite, trichomoniasis is often referred to as the most common curable sexually transmitted infection. However, most infected people have no symptoms, so it often goes untreated.

"Most women, it's the Number One sexually transmitted infection," says Alderete. "We're going to have at least 10 million women infected this year and an equal number of men because they all get infected if they come into contact with an infected partner."

Infected women have a greater risk of pregnancy complications and HIV. Infected men have a 40 percent greater chance of developing prostate cancer, according to a 2006 study led by Siobhan Sutcliffe, a Washington University epidemiologist and co-author of the recent PLoS Pathogens paper.

Sutcliffe cautions that the epidemiological link she found is not conclusive and compares the science to the early connections drawn between smoking and lung cancer.

"It's still in a really exploratory phase," she says.

A study after her 2006 research found no connection between trichomoniasis and prostate cancer, while a third out of Harvard found an even greater likelihood of cancer in infected men.

This latest study, she says, "is providing a molecular mechanism that might explain that association."

Much of the study was done in a single building, WSU's Biotechnology and Life Sciences Building, and involved two of the more accomplished researchers on the Pullman campus.

"This is just coincidence. I've only been here five years," says Alderete. "And when I arrived here five years ago, I had no clue that we would be going in this kind of direction. But the more I read and the more we talked in the hallways, the more it became clear that, wait a minute, we may have something here between us."

WSU cancer researcher Nancy Magnuson is an expert on the protein PIM1, a promoter of cancer cell growth, and identified the protein in the cascade of proteins leading from trichomoniasis to prostate cancer. WSU molecular biologist Ray Reeves brought to bear his expertise in HMGA1. The protein turns genes on and off and ended up being the actor making sure other proteins in the trichomoniasis-to-cancer sequence stay on.

Alderete hopes knowledge of the mechanism will lead to better diagnosis and treatment.

"What this is also doing is telling the world, 'People, this is a latent infection,'" he says. "'You guys out there, if you've been exposed to it, you've got it in there, and we need now a diagnostic for you.'"
'/>"/>

Contact: John Alderete, WSU professor of molecular biosciences
alderete@vetmed.wsu.edu
509-335-8125
Washington State University
Source:Eurekalert

Related medicine news :

1. URMC researchers connect new genetic signature to leukemia
2. Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
3. In war with superbugs, Cedars-Sinai researchers see new weapon: Immune-boosting vitamin
4. Midlife fitness staves off chronic disease at end of life, UT Southwestern researchers report
5. Moffitt Cancer Center researchers and colleagues identify PHF20, a regulator of gene P53
6. Cramming for a test? Dont do it, say UCLA researchers
7. Brigham and Womens Hospital researchers initiate major cardiovascular inflammation reduction trial
8. Johns Hopkins researchers return blood cells to stem cell state
9. Researchers highlight treatment, research needs for homeless families
10. Catalan researchers identify a key component of cell division
11. Spirituality correlates to better mental health regardless of religion, say MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... York, New York (PRWEB) , ... February 05, 2016 , ... ... life? The answer may be at the tips of your toes. Foot massage, whether ... as well as pure comfort and relaxation. The American Board of Multiple Specialties ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... franchises from across the country gathered at the La Valencia Hotel in San ... PROSHRED Chicago was named the year’s most outstanding franchise, walking away with ...
(Date:2/5/2016)... ... 05, 2016 , ... Pivot Point Consulting, a leading national ... & Services for HIT Implementation Support & Staffing report with an outstanding score ... by healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 clinics. ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Colorize ... from on one drop zone to the next using Colorize's dynamic moving camera. Colorize ... project. This package includes a 3D slideshow environment with 1 to 5 focus points ...
(Date:2/5/2016)... ... 05, 2016 , ... Calls Blacklist has just been updated by mobile app ... the developer has fixed known bugs within the app. Calls Blacklist allows its users ... not consuming any of their device’s battery power or memory. It provides a powerful ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016  SciClone Pharmaceuticals, Inc. (NASDAQ: ... has entered into a settlement agreement with the ... resolving the SEC,s investigation into possible violations of ... terms of the settlement agreement, SciClone has agreed ... disgorgement, pre-judgment interest and a penalty.  This payment ...
(Date:2/4/2016)... -- Global Immunology Market to 2022 - Large ... growth Summary Immune-mediated inflammatory diseases are ... affect 5–7% of western populations. Although they are ... key patient demographics, they are pathophysiologically linked, being ... inappropriate immune response. Generally, disease-modifying anti-rheumatic drugs, a ...
(Date:2/4/2016)...  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... treat life-threatening diseases, today announced results for the ... 2015. --> --> ... our last quarterly call, we strategically advanced pre-clinical ... to establish the Aethlon Hemopurifier® as a leading ...
Breaking Medicine Technology: