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WSU researcher creates patented personalized therapy that causes cancer cells to kill themselves
Date:2/28/2011

atients with a fully functional immune system.

Patients with the same cancer type vary in their response to identical treatment because the biological characteristics of the same cancer type usually differ between patients. As a result, the medical field strives to develop treatments that can be adjusted to each patient. The structure of Dr. Rosner's technology is flexible in that it contains Lego-like pieces that together form a genetic construct. Each piece can be replaced by one of several other genetic pieces that perform the same task, but differ slightly in their genetics. The multiple options available for each genetic piece will allow the physician to tailor the finalized treatment to each patient based on the unique characteristics of his or her cancer. In this way, the new technology is a "true personalized therapy" he said. The physician will expose a patient's cancer cells obtained by biopsy, to various genetic constructs to identify the version of therapy that kills the patient's cancer with the utmost efficiency.

Of particular importance is the potential for this technology to treat a large variety of tumors, such as prostate, lung and breast cancers. Dr. Rosner likened the therapy to the military's Tomahawk missile platform. The Tomahawk is directed to its target by programming the missile's homing device. Likewise, the destructive genetic construct can be targeted to a particular cancer type by incorporating a genetic piece that specifically identifies the cancer. Multiple genetic homing devices will be at the physician's disposal. The ability to target the therapy specifically to cancer cells will reduce side effects common with today's anti-cancer therapies. Moreover, the ability to target multiple cancers will immensely increase the number of cancer patients who will benefit from the new technology.

The one side effect that Dr. Rosner foresees is the potential for lightening of skin hue at a level that he cannot predict,
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Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

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