Navigation Links
WSU researcher creates patented personalized therapy that causes cancer cells to kill themselves
Date:2/28/2011

A Wayne State University School of Medicine physician-researcher has developed a personalized therapy to treat a wide range of cancers. The treatment is based on a naturally occurring human enzyme that has been genetically modified to fool cancer cells into killing themselves.

The unique concept, patented by Wayne State University, was successfully demonstrated on melanoma cells that are resistant to routine treatments such as chemotherapy or radiotherapy. Melanoma is a perfect model for testing this new therapy because it is considered the most aggressive form of human cancer due to its many defense mechanisms against available treatments. The success of the therapy in killing melanoma suggests a similar outcome in treating other cancers.

Developed by Karli Rosner, M.D., Ph.D., assistant professor and director of Research in the Department of Dermatology, the method uses genetic constructs that contain a genetically modified enzyme -- DNase1 protein -- to seek out and destroy cancer cells. The novel technology was published in the article "Engineering a waste management enzyme to overcome cancer resistance to apoptosis: adding DNase1 to the anti-cancer toolbox" in the Jan. 14 online edition of Cancer Gene Therapy, a Nature Publishing Group journal.

Dr. Rosner modified the genetic code for DNase1, a highly potent DNA-degrading enzyme, and altered its genetic composition by deleting a part of the code, mutating another part and adding an artificial piece of code. Through these changes, the altered DNA program is translated into a modified protein. In contrast to the natural protein, the modified protein will not be eliminated from the cancer cell, will resist deactivation by cell inhibitors and will gain access to the cell's nucleus. "If you imagine the cell's nucleus as a computer and DNA in the nucleus as computer software," Dr. Rosner explained, "then the altered, hacked DNA program corresponds to a computer virus."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Wayne State University researchers publish results settling multiple sclerosis debate
2. E-health must be a priority, researchers say
3. Compound used to block cholesterol could also kill breast cancer, MU researcher finds
4. Queens University researcher connects cannabis use and sexual dysfunction
5. Mayo Clinic researchers confirm value of therapeutic hypothermia after cardiac arrest
6. Mayo researchers, Rochester educators, students to present at science conference
7. Researchers work at the frontiers of islet cell transplantation
8. Brain Appears to Be a Task Machine, Researchers Say
9. Researchers develop outline that may help weigh benefits of new imaging technologies
10. University of Minnesota researchers study the use of computer vision to diagnose mental disorders
11. Researchers find brain insulin plays critical role in the development of diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... ... ... ... , UCLA researchers interviewed people with diverticulitis and confirmed that many suffer psychological and physical symptoms ... Research , a UCLA team led by Dr. Brennan Spiegel interviewed patients in great detail about the symptoms they experience weeks, months ...
(Date:7/30/2014)... 2014 Over 630 doctors worldwide are ... the revolutionary minimally invasive treatment for gum recession. Santa ... of his peers to be the “father of microsurgery” ... recent Chao Pinhole Surgical Technique® training course at the ... the recipient of the American Academy of Periodontics (AAP) ...
(Date:7/30/2014)... 30, 2014 The American Telemedicine ... Sens. Thad Cochran (R-MS) and Roger Wicker (R-MS) ... telemedicine coverage under Medicare, Medicaid and Federal Communications ... Mississippi Republicans, introduced the Telehealth Enhancement Act as ... version, H.R. 3306, introduced by Rep. Gregg Harper ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 The Institute ... is pleased to announce that Arianna Huffington has joined as ... of the Health Coach Training Program . , Arianna ... Post, a world-renowned news and blogging site that won a ... author of fourteen books and was included on the Forbes ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Frozen shoulder (Adhesive ... more likely to develop this nasty condition which occurs most ... and can last up to two and half years if ... frozen shoulder, and with good reason: it can render your ... — that is, if you aren't in too much pain ...
Breaking Medicine News(10 mins):Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 2Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 3Health News:Periodontist Dr. Dennis Shanelec Comments On The Chao Pinhole Surgical Technique® Training Course 2Health News:ATA Applauds Senators’ Push for Federal Telemedicine Improvements 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 3Health News:Good News for Diabetics Suffering from Frozen Shoulder 2Health News:Good News for Diabetics Suffering from Frozen Shoulder 3Health News:Good News for Diabetics Suffering from Frozen Shoulder 4
... CITY, Mo., June 19 President Emeritus of The Joint Commission, ... of Directors at the June 2009 meeting. , , ... Individual Achievement for his outstanding work during his tenure as President ... to have Dr. O,Leary join our Board of Directors," said TMC ...
... After recent ... as Reloxin, as a procedure on their website. , ... Houston, TX (PRWEB) June 19, 2009 -- Dysport (TM), a ... recently gained FDA approval and is expected to start hitting physicians, shelves in July, 2009. ...
... ... the 26th Annual ASMBS scheduled for June 21-26 in Dallas, TX. , ... Irvine, CA (PRWEB) June 19, 2009 -- Bariatric ... Annual ASMBS scheduled for June 21-26 in Dallas, TX. "The new products have been ...
... End of Health Coverage , , OAKLAND, Calif., ... National Nurses Organizing Committee/California Nurses Association -- which is ... reaction to the release of the GOP health proposal, ... health coverage, and force them into the individual market ...
... private corporations and average citizens sending money to their ... funding, according to a new study by the Institute ... of Washington. The research shows that funding for ... two decades from $5.6 billion in 1990 to ...
... of exotic animals like reptiles and birds need to be ... humans, according to a Kansas State University veterinarian. ... in K-State,s College of Veterinary Medicine, said exotic animals can ... factors to consider before owning one. , , West ...
Cached Medicine News:Health News:Joint Commission President Emeritus Joins Truman Medical Centers' Board of Directors 2Health News:Joint Commission President Emeritus Joins Truman Medical Centers' Board of Directors 3Health News:Dysport Added as a Procedure on AmericanHealthandBeauty.com: Let the Wrinkle Wars Begin 2Health News:Dysport Added as a Procedure on AmericanHealthandBeauty.com: Let the Wrinkle Wars Begin 3Health News:Bariatric Advantage to Introduce Ten (10) New Products at ASMBS 2Health News:Global health funding soars, boosted by unprecedented private giving 2Health News:Global health funding soars, boosted by unprecedented private giving 3Health News:K-State Veterinarian Says Although Exotic Pets Can Be Great Companions, There Are Health Factors That Can Affect Both the Animal and Humans 2Health News:K-State Veterinarian Says Although Exotic Pets Can Be Great Companions, There Are Health Factors That Can Affect Both the Animal and Humans 3
(Date:7/30/2014)... ARBOR, Mich. , July 30, 2014 Advanced ... first quarter (ending June 27, 2014) financial results on Monday, ... will be released after the close of the market and ... discuss the results at 4:30 p.m. EDT on the same ... Richard Kurtz (CEO and Director), Rob Risser ...
(Date:7/30/2014)... , July 30, 2014 In conjunction with ... 2014 financial results press release, you are invited to ... live over the internet on Thursday, August 7, 2014 ... A live audio webcast of the presentation ... http://www.durect.com and clicking "Investor Relations."  If you are ...
(Date:7/30/2014)... July 30, 2014 Research and Markets has ... - Forecasts to 2019" report to their offering. ... estimated to grow at a lower CAGR in developed countries; however, ... as China , India , ... The growth of the hematology analyzers and reagents market ...
Breaking Medicine Technology:Advanced Photonix to Webcast Fiscal 2015 First Quarter Earnings 2DURECT Corporation Invites You to Join its Second Quarter 2014 Earnings Conference Call 2Hematology Analyzers & Reagents Market - Forecasts to 2019 2
... interventional cardiology, accurate lesion assessment ... in determining the appropriate stent ... Cardiac 3-D (IC3D), a highly ... clinicians are now able to ...
... versatile solution designed to optimize the workflow ... to diagnosis and therapy, for both diagnostic ... your cath lab becomes an integral part ... free to concentrate on what really matters: ...
... FC is a floor-mounted, single ... system architecture for vascular and ... flexible and ergonomic system architecture ... the system configuration to focus ...
The ACUSON Sequoia C512 system elevates imaging and Doppler performance through new, high-density acoustic sampling, precise control of the transmitted acoustic waveform, and new transducer technolog...
Medicine Products: