In rankings of states with the highest number of reported cases in 2009, Michigan placed 13th with 457 cases of infection for every 100,000 people. Mississippi ranked first (802.7 per 100,000) and New Hampshire ranked last (159.7 per 100,000). Some studies estimated that in the UnitedStates alone there are 4 million to 5 million new cases of Chlamydia infection annually.
Another chlamydial species, Chlamydia pneumoniae, is responsible for 10 percent to 20 percent of community-acquired pneumonia in adults. Chlamydiae also have been associated with arthritis, atherosclerosis, stroke, myocarditis, chronic obstructive pulmonary disease, late-onset Alzheimer's and temporomandibular joint disease.
Whittum-Hudson noted that animals in which the prototype vaccine has been tested showed a decrease in joint inflammation, reducing the reactive arthritis-inducing effect of disseminated Chlamydia.
She said the vaccine may require boosters delivered at various stages of life. For instance, infants or children may be vaccinated, and then receive a booster immunization as they approach sexual maturity. A booster could be administered as a patient reaches age 40 to assist in warding off potential cardiovascular effects of Chlamydia. Another booster might prove beneficial at an older age to combat the effects of Chlamydia-associated late-onset Alzheimer's disease.
Another potential benefit of the vaccine lies in the livestock and poultry industries. Cattle, sheep and some poultry can contract Chlamydia, leading to illness and the self-aborting of fetuses, and respiratory infections in poultry. A viable vaccination could save the livestock industry untold millions of dollars and protect workers in the poultry industry who can contract the disease from infected animals.
Whittum-Hudson said that while her vac
|Contact: Julie O'Connor|
Wayne State University - Office of the Vice President for Research