Navigation Links
WHI reports $37.1B economic return on combined hormone therapy clinical trial
Date:5/6/2014

SEATTLE Economic findings were released today on the Women's Health Initiative (WHI), estrogen plus progestin (E+P) trial. The WHI is one of the largest National Institutes of Health-funded studies ever conducted on women. Housed at the Fred Hutchinson Cancer Research Center in Seattle, it is a 15-year, multimillion-dollar study established in 1991, involving more than 160,000 women nationwide, including some 3,500 in Washington.

The overall economic return from the WHI E+P trial indicates that changes in practice stemming from the trial provided a net economic return of $37.1 billion over the 10-year period since the main findings were published, providing a return of approximately $140 on every dollar invested in the trial.

The findings, published today in the Annals of Internal Medicine, are the result of collaboration between WHI investigators and faculty at the Hutchinson Institute for Cancer Outcomes Research. The researchers created a disease simulation model to evaluate clinical and economic outcomes for combined hormone therapy (cHT) eligible women since the initial publication of the E+P trial results in 2003.

The study first estimated clinical outcomes for women taking cHT following the study versus a counterfactual scenario where the E+P trial was not conducted and cHT use persisted at historical (pre-2003) trends. Based on the projected clinical outcomes, the study then calculated the net economic return of the trial, less the trial cost.

During the 10 years following publication of WHI E+P findings, the investigators estimated that 4.3 million fewer women used cHT. As a result there were 126,000 fewer breast cancer cases, 76,000 fewer cardiovascular events, 263,000 more osteoporotic fractures, and 15,000 more colorectal cancer cases compared to the no trial scenario. The observed reduction in cHT prescribing saved $49.5 billion in direct medical care costs. In addition, the net health yield for women in the U.S. was approximately 145,000 more quality-adjusted life years than would have occurred in absence of the trial. Assuming that 75% of the change in cHT prescribing can be directly attributed to the WHI, and subtracting the cost of the study itself ($260 million) the net economic return of WHI E+P trial was $37.1 billion.

"The WHI trial is often discussed as having a major impact on post-menopausal combined hormone therapy use, but I'm not aware of any other studies that have projected how many fewer women used combined hormone therapy as a result of the trial," said Joshua Roth, Ph.D., MHA, Hutchinson Institute for Cancer Outcomes Research, and lead author of the study. "It really brings the point home when you crunch the numbers, to see that millions of U.S. women likely stopped or never used combined hormone therapy based on the trial's findings, and that the change in use resulted in important reductions in disease incidence and associated medical spending."

Of the $37.1 billion in net economic return attributable to the WHI E+P trial, $26.4 billion was attributable to medical expenditure savings. These savings were driven by 25 million fewer person-years of cHT use, as well as cost savings from avoided diseases. The remaining $10.7 billion represents the value of additional quality-adjusted life expectancy resulting from lower incidence of breast cancer, cardiovascular disease, and venous thromboembolism.

"The motivation for the first WHI trial was to see if we could prevent heart disease, the number one killer of women. That's why we did it - the economics never occurred to me," said Garnet Anderson, Ph.D., lead Women's Health Initiative investigator and director of Fred Hutchinson Cancer Research Center's Public Health Sciences Division. "What these findings underscore is the significant role clinical trials play in science and the importance of continuing to find ways to strategically invest public research funds to maximize value to society."

The WHI E+P clinical trial was funded by the National Heart, Lung, and Blood Institute (NHLBI), and its success was realized by dedicated study participants who contributed their time to help answer important research questions. Today's report on the $37.1 billion economic return of its E+P trial suggests that large public research investments can yield considerable clinical and economic value when targeted to address research questions with high clinical relevance and public health impact.

"It is important to consider the potential value of studies when making decisions about how to invest limited public research dollars," said Scott Ramsey, M.D., Ph.D., Director of Hutchinson Institute for Cancer Outcome Research. "Many stakeholders have talked about the high cost of the WHI estrogen plus progestin trial, but few have considered the potential value of the trial. These findings show that the trial was a high-value use of public funds with a substantial return on investment."


'/>"/>

Contact: Michael Nank
mnank@fredhutch.org
206-667-6906
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. 1 in 3 households misreports smoke alarm coverage
2. Study examines necessity of additional imaging in PET/CT oncologic reports
3. Reactions to HIV drug have autoimmune cause, reports AIDS journal
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Well-known author and historian reports on progress in Huntingtons therapies
6. Actos Bladder Cancer Lawsuit Filed in Louisiana Alleging Woman Used Diabetes Medication and Contracted Bladder Cancer, Consumer Justice Foundation Reports
7. Oxford University Press acquires joint ownership of Journal of Surgical Case Reports
8. Two-Thirds of U.S. Youth Have Had Oral Sex, CDC Reports
9. NSF reports on R&D spending by businesses in the United States
10. No July phenomenon for neurosurgery patients, reports Neurosurgery
11. Virtual reality simulator helps teach surgery for brain cancer, reports Neurosurgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published ... rate of type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin ... a change in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Guruji Mahendra ... 9th, 10th and 11th, 2016 in honor of his birthday on February 10th. ... happiness. Mahendra Trivedi is known by over 250,000 people from over 40 different ...
(Date:2/7/2016)... ... February 07, 2016 , ... Women's Excellence staff, in all four locations, wore ... Wear Red Day is the first Friday each February and a day to bring ... in 3 deaths among women each year – more than all cancers combined. Go ...
(Date:2/6/2016)... San Rafael, CA (PRWEB) , ... February 06, 2016 , ... ... 2016 Youth Ultimate Coaching Conference (YUCC) . This event brings together top non-profit leaders, ... is “Gender Equity and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of ...
(Date:2/5/2016)... ... February 05, 2016 , ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran ... it started in 2003. This year, he ran all 26.2 miles with a green ... team the Miami Heat. , This Sunday, while many are watching the Superbowl, Steven ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)...   GS1 US will hold a series ... GS1 Standards implementation to address the requirements of the ... (UDI) rule. Scott Brown , director ... senior director industry development, medical devices, GS1 US; and ... --> Scott Brown , director ...
(Date:2/8/2016)... NORRITON, Pa. , Feb. 8, 2016 /PRNewswire/ ... of November Research Group (NRG),s pharmacovigilance technology ... pharmacovigilance system-related consulting services and an Oracle Argus ... compliance services to Life Sciences companies. ... strengthens and expands HighPoint,s life sciences capabilities and ...
(Date:2/8/2016)... PALO ALTO, Calif. , Feb. 8, 2016 ... chemical manufacturing, and Kodiak Sciences Inc., a biopharmaceutical company ... retinal disease, announced today agreements for the clinical supply ... manufacture material at multiple sites, including Slough (UK), Visp ... --> Retinal diseases, such as age-related ...
Breaking Medicine Technology: