Navigation Links
Vulnerability to post-traumatic stress disorder runs in families, study shows
Date:12/19/2008

Earthquakes have aftershocks not just the geological kind but the mental kind as well. Just like veterans of war, earthquake survivors can experience post-traumatic stress disorder, depression and anxiety.

In 1988, a massive earthquake in Armenia killed 17,000 people and destroyed nearly half the town of Gumri. Now, in the first multigenerational study of its kind, UCLA researchers studying survivors of that catastrophe have discovered that vulnerability to PTSD, anxiety and depression runs in families.

Armen Goenjian, a research psychiatrist in the UCLA Department of Psychiatry and Biobehavioral Sciences, and colleagues studied 200 participants from 12 multigenerational families exposed to the earthquake. Participants suffered from varying degrees of the disorders. The researchers found that 41 percent of the variation of PTSD symptoms was due to genetic factors and that 61 percent of the variation of depressive symptoms and 66 percent of anxiety symptoms were attributable to genetics. Further, they found that a large proportion of the genetic liabilities for the disorders were shared.

The research appears in the December issue of the journal Psychiatric Genetics.

"This was a study of multigenerational family members parents and offspring, grandparents and grandchildren, siblings, and so on and we found that the genetic makeup of some of these individuals renders them more vulnerable to develop PTSD, anxiety and depressive symptoms," said Goenjian, a member of the UCLADuke University National Center for Child Traumatic Stress and lead author of the study.

In addition, Goenjian noted, the study suggests that a large percentage of genes are shared between the disorders.

"That tracks with clinical experience," he said. "For example, in clinical practice, the therapist will often discover that patients who come in for treatment of depression have coexisting anxiety. Our findings show that a substantial portion of the coexistence can be explained on the basis of shared genes and not just environmental factors such as upbringing."

The researchers used statistical methods to assess heritabilities. One method was used to determine the genetic component of a disorder such as PTSD. Then, a separate analysis was used to see if different phenotypes shared genes. The results showed that a significant amount of genes are shared between PTSD and depression, PTSD and anxiety, and finally depression and anxiety.

Until now, Goenjian said, the only studies that have suggested such a heritability of PTSD have been twin studies.

"It's very hard to do family studies on PTSD because typically only single individuals, not whole families, are exposed to a particular trauma," he said. "In our study, we were able to avert this problem since all the subjects were exposed to the same severe trauma at the same time."

In fact, he said, the 200 participants all saw destroyed buildings throughout Gumri, 90 percent witnessed dead bodies left lying in the streets and 92 percent witnessed severely injured people.

The findings are promising for the next step in understanding the underlying biology of these disorders, which is locating the specific genes involved, Goenjian said.


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Vulnerability to Stress Linked to Brain Molecule
2. Lumension Security To Showcase Vulnerability Management Expertise With Whitehatworld.com Webcast
3. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
4. Study finds post-traumatic stress symptoms in adolescent children of cancer patients
5. Value of Most Post-Traumatic Stress Treatments Uncertain
6. Study links asthma and post-traumatic stress disorder
7. EEG Institute to Provide Free Post-Traumatic Stress Treatment for Iraq and Afghanistan Veterans
8. Predicting post-traumatic stress disorders in deployed veterans
9. Study suggests some brain injuries reduce the likelihood of post-traumatic stress disorder
10. Study: Treating post-traumatic stress first helps children overcome grief
11. Highest ever levels of post-traumatic stress found in Uganda
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... ... 21, 2017 , ... Pacifica Graduate Institute’s Alumni Association announced ... events for its annual meeting “Coming Home 2017,” an activity-packed weekend of educational ... will be held on Friday January 27 through Sunday, January 29, 2017 at ...
(Date:1/20/2017)... ... ... ADA Portable Motion Trek BP 300 Lift. Built for durability, this pool lift is easy ... wheeled out of the way and stored when not in use. It is freestanding and ... from customers into specific enhancements and created a new product that is built directly on ...
(Date:1/20/2017)... ... ... Bionic Sports Nutrition LLC, an American company devoted to developing high-quality nutritional supplements ... Trade Show in Hilton Head, SC. , Bionic Sports Nutrition manufactures its entire ... to all clients at reasonable prices. At the ECRM trade show, it had a ...
(Date:1/20/2017)... Viejo, California (PRWEB) , ... January 20, 2017 , ... ... easy to use inside of Final Cut Pro X," said Christina Austin - CEO ... on the RED Dragon. Utilizing the Dragon Sensor,TransFlare 4K Mystique lens flare and light ...
(Date:1/20/2017)... , ... January 20, 2017 , ... “I Forgive You”: a fine examination of ... Forgive You” is the creation of published author, Stephen Miller, who, for over ten long ... gracefully given to him. Born in Trinidad and Tobago, he has been serving the Lord ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... 20, 2017  Today, during a plenary ... Pathways in Immunology, Growth Disorders and Cancer," ... INFI ) presented preclinical data for ... selectively inhibits phosphoinositide-3-kinase-gamma (PI3K-gamma). Preclinical data showed ... resistance to checkpoint inhibition by remodeling the ...
(Date:1/20/2017)... Research and Markets has announced the addition of the ... Electrolyte Testing, HbA1c Testing, Comprehensive Metabolic Panel, Liver Panel, Renal Panel, ... report to their offering. ... The global clinical laboratory testing market is expected to ... solutions on the grounds of maximum efficiency and minimum error is ...
(Date:1/20/2017)... 2017 Stock-Callers.com today evaluates the following ... ), Novo Nordisk A/S (NYSE: NVO ), Sucampo ... Holdings Inc. (NASDAQ: PTX ). These stocks belong ... th , 2017, finishing near its session lows. As per ... 0.7%, while shares of health care companies in the S&P ...
Breaking Medicine Technology: