Navigation Links
Vulnerability to post-traumatic stress disorder runs in families, study shows
Date:12/19/2008

Earthquakes have aftershocks not just the geological kind but the mental kind as well. Just like veterans of war, earthquake survivors can experience post-traumatic stress disorder, depression and anxiety.

In 1988, a massive earthquake in Armenia killed 17,000 people and destroyed nearly half the town of Gumri. Now, in the first multigenerational study of its kind, UCLA researchers studying survivors of that catastrophe have discovered that vulnerability to PTSD, anxiety and depression runs in families.

Armen Goenjian, a research psychiatrist in the UCLA Department of Psychiatry and Biobehavioral Sciences, and colleagues studied 200 participants from 12 multigenerational families exposed to the earthquake. Participants suffered from varying degrees of the disorders. The researchers found that 41 percent of the variation of PTSD symptoms was due to genetic factors and that 61 percent of the variation of depressive symptoms and 66 percent of anxiety symptoms were attributable to genetics. Further, they found that a large proportion of the genetic liabilities for the disorders were shared.

The research appears in the December issue of the journal Psychiatric Genetics.

"This was a study of multigenerational family members parents and offspring, grandparents and grandchildren, siblings, and so on and we found that the genetic makeup of some of these individuals renders them more vulnerable to develop PTSD, anxiety and depressive symptoms," said Goenjian, a member of the UCLADuke University National Center for Child Traumatic Stress and lead author of the study.

In addition, Goenjian noted, the study suggests that a large percentage of genes are shared between the disorders.

"That tracks with clinical experience," he said. "For example, in clinical practice, the therapist will often discover that patients who come in for treatment of depression have coexisting anxiety. Our findings show that a substantial portion of the coexistence can be explained on the basis of shared genes and not just environmental factors such as upbringing."

The researchers used statistical methods to assess heritabilities. One method was used to determine the genetic component of a disorder such as PTSD. Then, a separate analysis was used to see if different phenotypes shared genes. The results showed that a significant amount of genes are shared between PTSD and depression, PTSD and anxiety, and finally depression and anxiety.

Until now, Goenjian said, the only studies that have suggested such a heritability of PTSD have been twin studies.

"It's very hard to do family studies on PTSD because typically only single individuals, not whole families, are exposed to a particular trauma," he said. "In our study, we were able to avert this problem since all the subjects were exposed to the same severe trauma at the same time."

In fact, he said, the 200 participants all saw destroyed buildings throughout Gumri, 90 percent witnessed dead bodies left lying in the streets and 92 percent witnessed severely injured people.

The findings are promising for the next step in understanding the underlying biology of these disorders, which is locating the specific genes involved, Goenjian said.


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Vulnerability to Stress Linked to Brain Molecule
2. Lumension Security To Showcase Vulnerability Management Expertise With Whitehatworld.com Webcast
3. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
4. Study finds post-traumatic stress symptoms in adolescent children of cancer patients
5. Value of Most Post-Traumatic Stress Treatments Uncertain
6. Study links asthma and post-traumatic stress disorder
7. EEG Institute to Provide Free Post-Traumatic Stress Treatment for Iraq and Afghanistan Veterans
8. Predicting post-traumatic stress disorders in deployed veterans
9. Study suggests some brain injuries reduce the likelihood of post-traumatic stress disorder
10. Study: Treating post-traumatic stress first helps children overcome grief
11. Highest ever levels of post-traumatic stress found in Uganda
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... 2017 , ... Current Meditation , a new meditation ... the U.S. starting this spring. Current Meditation focuses on “meditation for the modern ... Meditation will be the first meditation concept in the U.S. offering franchising opportunities, ...
(Date:2/23/2017)... ... February 23, 2017 , ... Top cosmetic and periodontal dentist ... today with a new Indiegogo campaign . Individuals are now able to contribute ... Los Angeles area, either as a participating patient or through an Indiegogo donation. The ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... of a new healthcare contact center in Georgia, PENETRON Specialty Products (PSP) provided ... nation’s largest healthcare systems recently invested $51 million to purchase and renovate the ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... secure messaging services to the largest network of hospitals, health information exchanges, ... National Coordinator for Health Information Technology (ONC-HIT) 2015 Edition Health IT Module Certification ...
(Date:2/22/2017)... ... February 22, 2017 , ... In a 2012 survey, ... or not filling a prescription because they could not afford to pay for ... medications were 30-60%*. At the same time, hospitals, pharmacies, manufacturers and ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 2017 On Wednesday, February 22, 2017, ... out of nine sectors finished the trading sessions in green, ... closing. Major US indices were also mixed at the close ... 5,860.63, slightly down by 0.09%; the Dow Jones Industrial Average ... 500 closed at 2,362.82, down 0.11%. This Thursday morning, Stock-Callers.com ...
(Date:2/23/2017)... 2017 ML Capital Group, Inc. (USOTC: MLCG) ... Highlife Tours , a Colorado -based cannabis ... Puration, Inc. (USOTC: PURA) to enter Colorado,s ... Colorado Highlife Tours acquisition announced today is intended to accelerate MLCG,s ... ...
(Date:2/23/2017)... and VANCOUVER, British Columbia ... OGXI ) today announced its year end ... In January 2017, OncoGenex, and Achieve Life Science, ... they have entered into a definitive merger agreement under ... Upon completion of the proposed merger, Achieve,s stockholders are ...
Breaking Medicine Technology: