Navigation Links
Voice-saver: Light therapy for early-stage laryngeal cancer
Date:1/28/2011

DETROIT Light, or photodynamic, therapy can help preserve the voice and vocal cord function for patients with early stage laryngeal (voice box) cancer, according to a study from Henry Ford Hospital in Detroit.

"Photodynamic therapy is an effective treatment for early laryngeal squamous cell carcinomas, offering patients a less invasive option with fewer side effects than other therapies, while preserving the voice," says study co-author Vanessa G. Schweitzer, FACS, M.D., a senior staff physician in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

The study will be presented Jan. 29 at the Triological Society's Combined Section Meeting in Scottsdale, Ariz.

Each year in the United States, more than 10,000 people are diagnosed with laryngeal cancer. Those who smoke and drink alcohol are at a greater risk, according to the National Cancer Institute. Laryngeal cancer is most commonly treated with radiation therapy alone or in combination with surgery or chemotherapy.

But photodynamic therapy offers some patients another option.

"It is a good alternative to radiation and surgery for early staged lesions. It can preserve function and allow us to reserve use of radiation therapy and surgery both known to have more functional impairment on vocal cord function should the cancer recur following photodynamic therapy," says study lead author Melissa L. Somers, M.D., with the Department of Otolaryngology-Head and Neck Surgery at Henry Ford.

Having already performed more than 200 procedures more than any other hospital in Michigan Henry Ford physicians are center stage in the application and research for this procedure.

Photodynamic therapy works by destroying deadly cancer cells without harming surrounding healthy tissue. It uses a powerful laser and a nontoxic, light-activated drug called PHOTOFRIN. The laser activates the drug, causing a reaction in the cancer cells and destroying them.

Since photodynamic therapy does not damage the underlying tissue, it not only allows for multiple treatments but also for it to be given prior to or following other therapies, and when radiation therapy fails.

However, there is not a consensus in research literature as to which treatment surgery, radiation therapy or photodynamic therapy produces the best outcome for voice preservation.

The current Henry Ford study focuses on 10 patients with early stage squamous cell tumors of the larynx treated with photodynamic therapy. The study assessed how well the vocal cords moved following photodynamic therapy.

Both before and after photodynamic therapy, patients underwent videostroboscopy exams, a state-of-the-art technique that provides a magnified, slow-motion view of the vocal cords in use. The technique uses a small, angled telescope inserted through the mouth or nose to measure vocal cord vibrations while patients repeat words or sounds.

Results were analyzed by a speech language pathologist and laryngologist specializing in voice disorders for vocal cord movement and vibration.

During the first five weeks following treatment, researchers noted a significant worsening in the non-vibrating portion of the affected vocal cords, which is expected, says Dr. Somers.

Ten weeks following treatment, there was a noticeable improvement.

"In our study, patients undergoing PDT demonstrated initial significant impairment in the vocal cord vibratory parameters of mucosal wave, non-vibrating vocal cold and amplitude of vibration as well as appearance of vocal cold edge for both the tumor and non-tumor side," says Dr. Somers. "Most notably, over the course of a few weeks and months, there were consistent trends toward normal vocal cord vibration."

Patients do experience minor side effects from treatment such as photosensitivity, making them more sensitive to light and susceptible to severe sunburns. This lasts for about four weeks following the procedure. Patients also may experience temporary hoarseness.

Dr. Somers hopes future studies are aimed at a prospective comparison of photodynamic therapy to surgery and radiation and subsequent voice production results.


'/>"/>

Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. Speaker series highlights the role of animals in human culture
2. Smoking Scenes in Movies Light Up Smokers Brains
3. Cigarette Ads Do Spur Teens to Light Up, Study Finds
4. Bright Lights at Night May Raise Diabetes Risk
5. Room light before bedtime may impact sleep quality, blood pressure and diabetes risk
6. Study sheds new light on river blindness parasite
7. Scientists shed light on what causes brain cell death in Parkinsons patients
8. Study Sheds Light on Genetic Risk of MS
9. Detecting esophageal cancer with light
10. Pop Stars Use of Salvia Puts Hallucinogen in the Spotlight
11. Research Sheds Light on Starvation Hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... , ... February 23, 2017 , ... The 89th Academy ... winner of the 2016 National Education Policy Center Bunkum Award. We invite you to ... 2016. , This year’s Bunkum winner is the Center for American Progress (CAP), for ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... with a clinician-based audience, will be participating in Rare Disease Day events, hosted ... D.C. In addition, Rare Disease Report, a website, weekly e-newsletter and quarterly publication, ...
(Date:2/23/2017)... ... ... Los Angeles-based weight loss surgeon Michael Feiz, M.D., F.AC.S. will be appearing ... which will begin airing on February 24, 2017. The show chronicles the weight loss ... television series, “Here Comes Honey Boo Boo.” The earlier series from TLC lasted for ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... thought leadership , media relations, content marketing, social media management, corporate communications, SEO ... already in the state and in nearby New Hampshire, Massachusetts and Canada, Rosica ...
(Date:2/23/2017)... ... 23, 2017 , ... On April 13, 2017, The ... “Doping in Sport: How the Culture Might Change,” in conjunction with Pepperdine ... will be held at Pepperdine University in Malibu, California. , Sir Philip Craven, ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Report analyzes the worldwide markets for Endodontic ... for the US, Canada , ... Asia-Pacific , Latin America , and ... the period 2015 through 2022. Also, a six-year historic analysis ... derived from primary and secondary research. Company profiles are primarily ...
(Date:2/24/2017)... ITL Limited, ( ASX : ITD ), une ... d,annoncer les excellents résultats semestriels clos le 31 décembre ... présentation complète « Résultats et mise à jour sur la ... Faits marquants ... $ ; en hausse de 104 %) Bénéfice ...
(Date:2/24/2017)... , Feb. 23, 2017  This report analyzes ... by the following Products: Intermediates, Analytical, ... the report include Pharmaceuticals, and Agrochemicals. The report provides ... , Europe , and Rest ... the period 2015 through 2022. Also, a six-year historic ...
Breaking Medicine Technology: