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Vitamin K linked to insulin resistance in older men
Date:11/26/2008

BOSTON - (November 26, 2008) Vitamin K slowed the development of insulin resistance in elderly men in a study of 355 non-diabetic men and women ages 60 to 80 who completed a three-year clinical trial at the Jean Mayer Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA).

"Men who received vitamin K supplementation had less progression in their insulin resistance by the end of the clinical trial," said Sarah Booth, senior author and director of the Vitamin K Laboratory at the USDA HNRCA. "Conversely, we saw progression in insulin resistance in women who received vitamin K supplementation, and in the men or women who were not given vitamin K supplements."

Among those given vitamin K, both men and women took daily multivitamins containing 500 micrograms of vitamin K, five times the Adequate Intake (AI) recommended by the Institute of Medicine's Food and Nutrition Board, with instructions to maintain normal diets without any additional supplementation. They also received a calcium and vitamin D supplement. Men and women in the control group received no vitamin K supplementation but did receive the multivitamin and the calcium and vitamin D supplement. For the present study, insulin resistance was assessed by the homeostasis model (HOMA-IR). Additionally, participants' blood glucose and blood insulin levels were measured following a minimum 10-hour fast. In addition to improved insulin resistance, the supplemented men had lower blood insulin levels compared to the unsupplemented men at the conclusion of the study.

Insulin is a hormone which plays a role in transporting sugar into cells so it can be converted into energy. A pre-cursor to diabetes, insulin resistance occurs when the body cannot use insulin properly, causing glucose to build up in the blood. People who are obese or overweight are prone to insulin resistance because excess fat can interfere with insulin function.

Writing in the November issue
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Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

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