Navigation Links
Vitamin D protects cells from stress that can lead to cancer
Date:5/13/2008

By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.

Many epidemiological studies have suggested the beneficial properties of vitamin D, said Yi-Fen Lee, associate professor of urology at the Medical Center who led the research. Our findings reflect what we see in those studies and demonstrate that vitamin D not only can be used as a therapy for prostate cancer, it can prevent prostate cancer from happening.

The International Journal of Cancer published the findings in its June 15 issue.

Lee and her research team discovered one mechanism involving vitamin D that protects cells from oxidative stress. The vitamin D used in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. Nonmalignant human prostate epithelial cells also were used.

Normal metabolism in cells generates reactive oxygen species (ROS), molecules of peroxide, for example, or so-called free radicals. These substances can play a role in cell signaling and even kill bacteria. Exposure to some chemicals or forms of radiation can produce high levels of ROS that can damage DNA and play a significant role in speeding aging or causing cancer.

Lee found that vitamin D links with a gene known as G6PD, increasing its activity and the production of an enzyme called glucose-6-phosphate dehydrogenase. Increased activity of the enzyme clears cells of ROS, the molecules that can damage and injure cells.

If you reduce DNA damage, you reduce the risk of cancer or aging, Lee said. Our study adds one more beneficial effect of taking a vitamin D supplement. Taking a supplement is especially important for senior citizens and others who might have less circulation of vitamin D, and for people who live and work areas where there is less sunshine.

Large amounts of vitamin D should not be taken without medical supervision, she said.

The G6PD pathway is one of the mechanisms vitamin D uses, Lee said. The researchers did not find any similar activity in prostate cancer cells.

Vitamin D does not protect cancer cells from injury or damage, which is good, Lee said.


'/>"/>

Contact: Michael Wentzel
Michael_Wentzel@urmc.rochester.edu
585-275-1309
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Expectant Moms Offered Free Prenatal Prescription Vitamins at D-FW Area Carnival, Minyard and Sackn Save Stores
2. Study shows common vitamin and other micronutrient supplements reduce risks of TB recurrence
3. Hero Nutritionals Introduces a New Adult Vitamin for the Taste Buds
4. Old Orchard Introduces First Multi-Serve Vitamin Water, Sweetened with Agave Nectar and Real Fruit Juice
5. Vitamin D and breast cancer risk
6. Low Vitamin D Levels Associated With an Increased Risk of Peripheral Arterial Disease
7. Low Vitamin D Levels Linked to Leg Artery Blockages
8. High Doses of Vitamin E Lengthen Lives of Alzheimers Patients
9. Nature Made(R) Changes the Way America Takes Vitamins
10. Folate scores a win in animal studies: Brief, high doses of B vitamin blunt damage from heart attack
11. Too Little Vitamin D May Soften Babys Skull
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... 10, 2016 , ... United Benefit Advisors (UBA), the nation’s ... to its growing list of Partner Firms. S.S. Nesbitt is headquartered in ... Huntsville and in between. , Harnessing the experience and insights of the agency’s ...
(Date:2/10/2016)... ... 2016 , ... AHRA: The Association for Medical Imaging Management ... will serve as keynote speaker at the organization’s 2016 Spring Conference. Fox’s topic, ... effectively communicate with their own organizational staff and leadership. , “I am ...
(Date:2/10/2016)... Palm Beach, Florida (PRWEB) , ... February 10, ... ... & Country Club) announced that it has been awarded the prestigious Distinguished Emerald ... the World award program conducted by BoardRoom magazine, one of the most respected ...
(Date:2/10/2016)... ... February 10, 2016 , ... Workrite Ergonomics this week ... series of monitor mounts ever. , “Our goal was to develop a product ... install system that we have ever created.” said Darren Hulsey, Product Manager for Workrite ...
(Date:2/10/2016)... ... , ... A new leadership team for Mid-South Youth Camp, operated by Freed-Hardeman ... announcement Monday night, Feb. 8, prior to the evening session of the university’s 80th ... of GO! Camp, has been named director. Gayle McDonald, currently the assistant director of ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... 10, 2016 Urologix, the market leader for ... Benign Prostatic Hyperplasia (BPH), announces new private ownership and ... a medical device industry veteran of more than 20 ... Company.  Plymouth, Minn. ... ThermoTherapy™ and Prostiva® RF Therapy, will continue to be ...
(Date:2/10/2016)... -- A Worldwide Clinical Trials expert will present ... Park Plaza in London , 24-25 February ... future advances for late phase research on Wednesday, 24 Feb ... associate director of project management at Worldwide, will focus on ... and standards in late phase research. --> ...
(Date:2/10/2016)... DIEGO , Feb. 10, 2016  Visage ... Pro Medicus Ltd. (ASX: PME), has announced that the ... of Florida (UF) have selected the Visage 7 ... viewer of the Emergent/Critical Care Imaging SIMulation (SIM). ... in Diagnostic Imaging Program (WIDI), a multi-faceted and ...
Breaking Medicine Technology: