Navigation Links
Vitamin D protects cells from stress that can lead to cancer
Date:5/13/2008

By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.

Many epidemiological studies have suggested the beneficial properties of vitamin D, said Yi-Fen Lee, associate professor of urology at the Medical Center who led the research. Our findings reflect what we see in those studies and demonstrate that vitamin D not only can be used as a therapy for prostate cancer, it can prevent prostate cancer from happening.

The International Journal of Cancer published the findings in its June 15 issue.

Lee and her research team discovered one mechanism involving vitamin D that protects cells from oxidative stress. The vitamin D used in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. Nonmalignant human prostate epithelial cells also were used.

Normal metabolism in cells generates reactive oxygen species (ROS), molecules of peroxide, for example, or so-called free radicals. These substances can play a role in cell signaling and even kill bacteria. Exposure to some chemicals or forms of radiation can produce high levels of ROS that can damage DNA and play a significant role in speeding aging or causing cancer.

Lee found that vitamin D links with a gene known as G6PD, increasing its activity and the production of an enzyme called glucose-6-phosphate dehydrogenase. Increased activity of the enzyme clears cells of ROS, the molecules that can damage and injure cells.

If you reduce DNA damage, you reduce the risk of cancer or aging, Lee said. Our study adds one more beneficial effect of taking a vitamin D supplement. Taking a supplement is especially important for senior citizens and others who might have less circulation of vitamin D, and for people who live and work areas where there is less sunshine.

Large amounts of vitamin D should not be taken without medical supervision, she said.

The G6PD pathway is one of the mechanisms vitamin D uses, Lee said. The researchers did not find any similar activity in prostate cancer cells.

Vitamin D does not protect cancer cells from injury or damage, which is good, Lee said.


'/>"/>

Contact: Michael Wentzel
Michael_Wentzel@urmc.rochester.edu
585-275-1309
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Expectant Moms Offered Free Prenatal Prescription Vitamins at D-FW Area Carnival, Minyard and Sackn Save Stores
2. Study shows common vitamin and other micronutrient supplements reduce risks of TB recurrence
3. Hero Nutritionals Introduces a New Adult Vitamin for the Taste Buds
4. Old Orchard Introduces First Multi-Serve Vitamin Water, Sweetened with Agave Nectar and Real Fruit Juice
5. Vitamin D and breast cancer risk
6. Low Vitamin D Levels Associated With an Increased Risk of Peripheral Arterial Disease
7. Low Vitamin D Levels Linked to Leg Artery Blockages
8. High Doses of Vitamin E Lengthen Lives of Alzheimers Patients
9. Nature Made(R) Changes the Way America Takes Vitamins
10. Folate scores a win in animal studies: Brief, high doses of B vitamin blunt damage from heart attack
11. Too Little Vitamin D May Soften Babys Skull
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... February 19, 2017 , ... ProBrand Glitch is a set of 30 glitch distortion logo reveals ... easily reveal any logo with a glitch reveal in just a few clicks of a ... and animation of each preset. Use these presets to add a uniquely animated logo to ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused start-ups, ... in the industry, according to the recent NEJM Catalyst Insights Report on the ... the NEJM Catalyst Insights Council, a qualified group of U.S. executives, clinical leaders, ...
(Date:2/18/2017)... CA (PRWEB) , ... February 18, 2017 , ... ... paragraph presets. Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 ... and so many other applications. Users can pick and choose from hand-crafted ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... foundational and sustainable systems change designed to further positively impact the health and ... of Trustees has long considered it our duty to seriously consider releasing our ...
(Date:2/17/2017)... ... February 17, 2017 , ... Empowering each ... goals for each and every seminar, session and class she offers. ... different brainwave tools which help energize creativity, focus mental functions, enhance athletic focus ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb. 17, 2017 Theravance Biopharma, ... or the "Company") today announced the presentation of ... and orally administered pan-Janus kinase (JAK) inhibitor designed ... Congress of the European Crohn,s and Colitis ... reported further data from its completed Phase 1 ...
(Date:2/17/2017)... Research and Markets has announced the addition of ... their offering. ... separate comprehensive analytics for the US, Canada , ... , Latin America , and Rest of World. ... Also, a six-year historic analysis is provided for these markets. Market data ...
(Date:2/17/2017)... , Feb. 17, 2017   FormFast , ... announced a new partnership with Engage , one ... United States . FormFast will serve as the ... Engage,s implementations with MEDITECH .  ... essential functionality to complement and enhance the electronic health ...
Breaking Medicine Technology: