Navigation Links
Vitamin D protects cells from stress that can lead to cancer
Date:5/13/2008

By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.

Many epidemiological studies have suggested the beneficial properties of vitamin D, said Yi-Fen Lee, associate professor of urology at the Medical Center who led the research. Our findings reflect what we see in those studies and demonstrate that vitamin D not only can be used as a therapy for prostate cancer, it can prevent prostate cancer from happening.

The International Journal of Cancer published the findings in its June 15 issue.

Lee and her research team discovered one mechanism involving vitamin D that protects cells from oxidative stress. The vitamin D used in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. Nonmalignant human prostate epithelial cells also were used.

Normal metabolism in cells generates reactive oxygen species (ROS), molecules of peroxide, for example, or so-called free radicals. These substances can play a role in cell signaling and even kill bacteria. Exposure to some chemicals or forms of radiation can produce high levels of ROS that can damage DNA and play a significant role in speeding aging or causing cancer.

Lee found that vitamin D links with a gene known as G6PD, increasing its activity and the production of an enzyme called glucose-6-phosphate dehydrogenase. Increased activity of the enzyme clears cells of ROS, the molecules that can damage and injure cells.

If you reduce DNA damage, you reduce the risk of cancer or aging, Lee said. Our study adds one more beneficial effect of taking a vitamin D supplement. Taking a supplement is especially important for senior citizens and others who might have less circulation of vitamin D, and for people who live and work areas where there is less sunshine.

Large amounts of vitamin D should not be taken without medical supervision, she said.

The G6PD pathway is one of the mechanisms vitamin D uses, Lee said. The researchers did not find any similar activity in prostate cancer cells.

Vitamin D does not protect cancer cells from injury or damage, which is good, Lee said.


'/>"/>

Contact: Michael Wentzel
Michael_Wentzel@urmc.rochester.edu
585-275-1309
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Expectant Moms Offered Free Prenatal Prescription Vitamins at D-FW Area Carnival, Minyard and Sackn Save Stores
2. Study shows common vitamin and other micronutrient supplements reduce risks of TB recurrence
3. Hero Nutritionals Introduces a New Adult Vitamin for the Taste Buds
4. Old Orchard Introduces First Multi-Serve Vitamin Water, Sweetened with Agave Nectar and Real Fruit Juice
5. Vitamin D and breast cancer risk
6. Low Vitamin D Levels Associated With an Increased Risk of Peripheral Arterial Disease
7. Low Vitamin D Levels Linked to Leg Artery Blockages
8. High Doses of Vitamin E Lengthen Lives of Alzheimers Patients
9. Nature Made(R) Changes the Way America Takes Vitamins
10. Folate scores a win in animal studies: Brief, high doses of B vitamin blunt damage from heart attack
11. Too Little Vitamin D May Soften Babys Skull
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
Breaking Medicine Technology: