Navigation Links
Vitamin D may protect against lung function impairment and decline in smokers
Date:7/19/2012

Vitamin D deficiency is associated with worse lung function and more rapid decline in lung function over time in smokers, suggesting that vitamin D may have a protective effect against the effects of smoking on lung function, according to a new study from researchers in Boston.

"We examined the relationship between vitamin D deficiency, smoking, lung function, and the rate of lung function decline over a 20 year period in a cohort of 626 adult white men from the Normative Aging Study," said lead author Nancy E. Lange, MD, MPH, of the Channing Laboratory, Brigham and Women's Hospital. "We found that vitamin D sufficiency (defined as serum vitamin D levels of >20 ng/ml) had a protective effect on lung function and the rate of lung function decline in smokers."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the study, vitamin D levels were assessed at three different time points between 1984 and 2003, and lung function was assessed concurrently with spirometry.

In vitamin D deficient subjects, for each one unit increase in pack-years of smoking, mean forced expiratory volume in one second (FEV1) was 12 ml lower, compared with a mean reduction of 6.5 ml among subjects who were not vitamin D deficient. In longitudinal models, vitamin D deficiency exacerbated the effect of pack years of smoking on the decline in FEV1 over time.

No significant effect of vitamin D levels on lung function or lung function decline were observed in the overall study cohort, which included both smokers and non-smokers.

"Our results suggest that vitamin D might modify the damaging effects of smoking on lung function," said Dr. Lange. "These effects might be due to vitamin D's anti-inflammatory and anti-oxidant properties."

The study has some limitations, including that the data is observational only and not a trial, that vitamin D levels fluctuate over time, and that the study has limited generalizability due to the cohort being all elderly men.

"If these results can be replicated in other studies, they could be of great public health importance," said Dr. Lange. "Future research should also examine whether vitamin D protects against lung damage from other sources, such as air pollution."

"While these results are intriguing, the health hazards associated with smoking far outweigh any protective effect that vitamin D may have on lung function ," said Alexander C. White MS, MD, chair of the American Thoracic Society's Tobacco Action Committee. "First and foremost, patients who smoke should be fully informed about the health consequences of smoking and in addition be given all possible assistance to help them quit smoking."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Adding Vitamin B12 to Standard Drugs Might Help Fight Hepatitis C
2. Vitamin E may lower liver cancer risk
3. Increase in RDA for vitamin C could help reduce heart disease, stroke, cancer
4. Vitamin D deficiency and poorer lung function in asthmatic children treated with steroids
5. Higher but not lower doses of vitamin D are effective in fracture risk reduction in older adults
6. Higher Doses of Vitamin D Prevent Fractures in Older Women
7. Low Vitamin D Levels Linked to Weight Gain in Older Women
8. 2 new vitamin D blood tests are often highly inaccurate, researchers say
9. The Gluten Free Society Talks About Vitamin Contamination
10. Older Women Should Not Take Calcium, Vitamin D: Task Force
11. Older adults may need more vitamin D to prevent mobility difficulties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Coco Libre, ... participation in Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer ... to stay hydrated before the big event. The invitation-only gifting suite, held this year ...
(Date:2/12/2016)... ... February 12, 2016 , ... Itopia, a leader in ... of Clarity Intelligence Platform (CIP) into Cielo®, a discovery, migration and cloud orchestration ... to their small and medium business (SMB) clients. , In recent ...
(Date:2/12/2016)... ... 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with ... will raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and ... is in a low-income area and has more than 60 2nd and 3rd graders ...
(Date:2/12/2016)... ... 2016 , ... Erlanger Agency has announced a new partnership in its ongoing ... focuses on the fight against breast cancer, fundraising for a local woman named Carmen, ... , Carmen is a loving single mother of two boys who also serves as ...
(Date:2/12/2016)... MIAMI, FLA (PRWEB) , ... February 12, 2016 , ... ... free dental implants to their Miami dental office. Beginning in January, Miami Dental ... traditional titanium. Miami Dental Specialists are the first office to be chosen by the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Feb. 12, 2016  This month,s issue of ... (JMCP) takes an in-depth look at various causes ... in prescription drug spending, which has generated significant public ... Editor-in-Chief Laura E. Happe , PharmD, MPH. ... Happe , PharmD, MPH. --> In 2014 ...
(Date:2/12/2016)... Pharmacy, Inc. (NYSE: DPLO ) is pleased to announce the promotion of Paul ... Jan. 23, 2016. To learn more about ... ... ... In his ...
(Date:2/12/2016)... NY , Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces ... to Okaloosa County Emergency ... Type III ambulances and one LT2 van. Quality Emergency Vehicles ... dealer, is responsible for the sale.  This is the latest ... LaFortune , Executive Vice President at Demers. --> ...
Breaking Medicine Technology: