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Vitamin C improves lung function in newborns of pregnant smoking women
Date:5/22/2012

PORTLAND, Ore. Women who are unable to quit smoking during pregnancy can significantly improve the lung function of their newborns by taking Vitamin C daily, according to a new study at Oregon Health & Science University Doernbecher Children's Hospital.

"Smoking during pregnancy is known to adversely affect the lung development of the developing baby, causing lifelong decreased lung function and an increased risk of asthma," said Cindy McEvoy, M.D., M.C.R., neonatologist and associate professor of pediatrics at OHSU Doernbecher Children's Hospital. "We found that babies born to pregnant smoking women who took 500 milligrams of Vitamin C daily during their pregnancy had significantly improved pulmonary function tests measured at about 48 hours after delivery."

The results will be presented at the American Thoracic Society 2012 International Conference in San Francisco May 22.

In this pilot study, McEvoy and colleagues randomly assigned 159 pregnant women who were unable to quit smoking to either daily Vitamin C or a placebo starting before 22 weeks gestation through delivery. A group of nonsmoking pregnant women also was studied as a reference group.

The researchers measured the pulmonary function in all newborns at approximately 48 hours of age and found the newborns of smoking women who received Vitamin C supplementation had significantly improved lung function compared with the newborns of smoking women who received a placebo, as measured by standard newborn pulmonary function testing (TPTeF:TE and Crs).

In addition, the scientists found that one particular genetic variant that has been shown to increase the risk of smokers developing cancer and is associated with both a reduced ability to quit smoking and a high likelihood of relapse also seemed to intensify the harmful effects of maternal smoking on babies' lungs.

"Getting women to quit smoking during pregnancy has to be priority one, but this study pro
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Contact: Tamara Hargens-Bradley
hargenst@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

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